Amino acid sequence identification and anti-inflammatory potency evaluation of dandelion oligopeptides in LPS-induced RAW264.7 macrophage cells

2020 ◽  
Vol 1216 ◽  
pp. 128280
Author(s):  
Jicai Lai ◽  
Lizhi Peng ◽  
Hongda Chen ◽  
Ruiming Li ◽  
Liuyi Liu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Macrophage Cells ◽  
Sequence Identification ◽  
Anti Inflammatory ◽  
Raw264.7 Macrophage

scholarly journals Identification of the Active Principle Conferring Anti-Inflammatory and Antinociceptive Properties in Bamboo Plant

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3054
Author(s):  
Bruna Araujo Sousa ◽  
Osmar Nascimento Silva ◽  
William Farias Porto ◽  
Thales Lima Rocha ◽  
Luciano Paulino Silva ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Folk Medicine ◽  
Active Principle ◽  
Therapeutic Effects ◽  
Protein Biochemistry ◽  
Antinociceptive Effects ◽  
Cellular Pathways ◽  
Anti Inflammatory ◽  
Bamboo Plant

Early plants began colonizing earth about 450 million years ago. During the process of coevolution, their metabolic cellular pathways produced a myriad of natural chemicals, many of which remain uncharacterized biologically. Popular preparations containing some of these molecules have been used medicinally for thousands of years. In Brazilian folk medicine, plant extracts from the bamboo plant Guadua paniculata Munro have been used for the treatment of infections and pain. However, the chemical basis of these therapeutic effects has not yet been identified. Here, we performed protein biochemistry and downstream pharmacological assays to determine the mechanisms underlying the anti-inflammatory and antinociceptive effects of an aqueous extract of the G. paniculata rhizome, which we termed AqGP. The anti-inflammatory and antinociceptive effects of AqGP were assessed in mice. We identified and purified a protein (AgGP), with an amino acid sequence similar to that of thaumatins (~20 kDa), capable of repressing inflammation through downregulation of neutrophil recruitment and of decreasing hyperalgesia in mice. In conclusion, we have identified the molecule and the molecular mechanism responsible for the anti-inflammatory and antinociceptive properties of a plant commonly used in Brazilian folk medicine.

scholarly journals Erratum to: Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells

2016 ◽  
Vol 59 (6) ◽  
pp. 889-889
Author(s):  
Ah Young Lee ◽  
Sullim Lee ◽  
Hyun Young Kim ◽  
Sanghyun Lee ◽  
Eun Ju Cho
Keyword(s):  
Macrophage Cells ◽  
Anti Inflammatory ◽  
Taraxacum Coreanum ◽  
Raw264.7 Macrophage

Factors affecting anti-inflammatory effect of chitooligosaccharides in lipopolysaccharides-induced RAW264.7 macrophage cells

2009 ◽  
Vol 19 (23) ◽  
pp. 6655-6658 ◽  
Author(s):  
Sang-Hoon Lee ◽  
Mahinda Senevirathne ◽  
Chang-Bum Ahn ◽  
Se-Kwon Kim ◽  
Jae-Young Je
Keyword(s):  
Factors Affecting ◽  
Macrophage Cells ◽  
Anti Inflammatory ◽  
Raw264.7 Macrophage ◽  
Inflammatory Effect

Anti-inflammatory Effects of Korean Propolis Extracts on Raw264.7 Macrophage Cells

2018 ◽  
Vol 33 (3) ◽  
pp. 187-194
Author(s):  
Sung-Kuk Kim ◽  
SoonOk Woo ◽  
Sangmi Han ◽  
Se Gun Kim ◽  
Kyung Won Bang ◽  
...  
Keyword(s):  
Macrophage Cells ◽  
Korean Propolis ◽  
Anti Inflammatory ◽  
Raw264.7 Macrophage

scholarly journals Anti-inflammatory phenolics isolated from Juniperus rigida leaves and twigs in lipopolysaccharide-stimulated RAW264.7 macrophage cells

2011 ◽  
Vol 27 (6) ◽  
pp. 875-879 ◽  
Author(s):  
Eun Ju Jeong ◽  
Hanee Seo ◽  
Heejung Yang ◽  
Jinwoong Kim ◽  
Sang Hyun Sung ◽  
...  
Keyword(s):  
Macrophage Cells ◽  
Anti Inflammatory ◽  
Raw264.7 Macrophage

Synthesis of novel anti-inflammatory peptides derived from the amino-acid sequence of the bioactive protein SV-IV

2001 ◽  
Vol 268 (12) ◽  
pp. 3399-3406 ◽  
Author(s):  
Armando Ialenti ◽  
Vincenzo Santagada ◽  
Giuseppe Caliendo ◽  
Beatrice Severino ◽  
Ferdinando Fiorino ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells

2016 ◽  
Vol 59 (5) ◽  
pp. 747-754 ◽  
Author(s):  
Ah Young Lee ◽  
Sullim Lee ◽  
Hyun Young Kim ◽  
Sanghyun Lee ◽  
Eun Ju Cho
Keyword(s):  
Macrophage Cells ◽  
Anti Inflammatory ◽  
Taraxacum Coreanum ◽  
Raw264.7 Macrophage
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