Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies

Pyrimidine Moiety

Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells

Medicinal Chemistry Research ◽

10.1007/s00044-021-02784-9 ◽

2021 ◽

Vol 30 (10) ◽

pp. 1925-1942

Author(s):

Karim I. Mersal ◽

Mohammed S. Abdel-Maksoud ◽

Eslam M. H. Ali ◽

Usama M. Ammar ◽

Seyed-Omar Zaraei ◽

...

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Pyridine Derivatives ◽

Design Synthesis ◽

Tert Butyl ◽

Macrophage Cells ◽

Raw264.7 Macrophage

Design, synthesis, crystal structure, molecular docking studies of some diorganotin(IV) complexes derived from the piperonylic hydrazide Schiff base ligands as cytotoxic agents

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.129992 ◽

2021 ◽

Vol 1232 ◽

pp. 129992

Author(s):

Jai Devi ◽

Jyoti Yadav ◽

Kashmiri Lal ◽

Nikhil Kumar ◽

Avijit Kumar Paul ◽

...

Keyword(s):

Crystal Structure ◽

Schiff Base ◽

Molecular Docking ◽

Docking Studies ◽

Cytotoxic Agents ◽

Schiff Base Ligands ◽

Design Synthesis ◽

Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116136 ◽

2021 ◽

pp. 116136

Author(s):

Mohammad Mahboob Alam ◽

Azizah M. Malebari ◽

Syed Nazreen ◽

Thikryat Neamatallah ◽

Abdulraheem SA Almalki ◽

...

Keyword(s):

Breast Cancer ◽

Molecular Docking ◽

Cancer Cells ◽

Thymidylate Synthase ◽

Breast Cancer Cells ◽

Docking Studies ◽

Design Synthesis ◽

Thymidylate Synthase Inhibitors

Design, Synthesis and molecular docking studies of new Azomethine derivatives as promising anti-inflammatory agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105595 ◽

2022 ◽

pp. 105595

Author(s):

Sulaksha R. Desai ◽

Vidya G. Desai ◽

Raghuvir R. Pissurlenkar

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Design Synthesis ◽

Anti Inflammatory

Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors

Chemistry Central Journal ◽

10.1186/s13065-018-0515-1 ◽

2018 ◽

Vol 12 (1) ◽

Cited By ~ 1

Author(s):

Jineetkumar Gawad ◽

Chandrakant Bonde

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Biological Evaluation ◽

Pyridine Derivatives ◽

Antitubercular Agents ◽

Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2016.10.001 ◽

2016 ◽

Vol 69 ◽

pp. 77-90 ◽

Cited By ~ 21

Author(s):

Raquib Alam ◽

Divya Wahi ◽

Raja Singh ◽

Devapriya Sinha ◽

Vibha Tandon ◽

...

Keyword(s):

Molecular Docking ◽

Anticancer Agents ◽

Inhibitory Activity ◽

Docking Studies ◽

Pyrazole Derivatives ◽

Design Synthesis ◽

Hybrid phenylthiazole and 1,3,5-triazine target cytosolic leucyl-tRNA synthetase for antifungal action as revealed by molecular docking studies

In Silico Pharmacology ◽

10.1186/2193-9616-1-3 ◽

2013 ◽

Vol 1 (1) ◽

Cited By ~ 9

Author(s):

Udaya Pratap Singh ◽

Hans Raj Bhat ◽

Prashant Gahtori ◽

Ramendra K Singh

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Trna Synthetase ◽

Antifungal Action

Indazoles as potential c-met inhibitors: Design, synthesis and molecular docking studies

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.04.004 ◽

2013 ◽

Vol 65 ◽

pp. 112-118 ◽

Cited By ~ 21

Author(s):

Lianbao Ye ◽

Xiaomin Ou ◽

Yuanxin Tian ◽

Bangwei Yu ◽

Yan Luo ◽

...

Keyword(s):

Molecular Docking ◽

Docking Studies ◽

Design Synthesis ◽

1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies

Bioorganic Chemistry ◽

10.1016/j.bioorg.2018.09.015 ◽

2018 ◽

Vol 81 ◽

pp. 630-641 ◽

Cited By ~ 16

Author(s):

Sana Tariq ◽

Payal Kamboj ◽

Ozair Alam ◽

Mohd. Amir

Keyword(s):

Molecular Docking ◽

Map Kinase ◽

Docking Studies ◽

Inflammatory Activity ◽

Kinase Inhibition ◽

Design Synthesis ◽

Anti Inflammatory ◽

P38α Map Kinase

Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and α-glycosidase enzymes inhibitors

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2020.1811772 ◽

2020 ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Afat Huseynova ◽

Ruya Kaya ◽

Parham Taslimi ◽

Vagif Farzaliyev ◽

Xadija Mammadyarova ◽

...

Keyword(s):

Molecular Docking ◽

Carbonic Anhydrase ◽

Docking Studies ◽

Biological Evaluation ◽

Design Synthesis ◽