Structural inspection for Novel Pd(II), VO(II), Zn(II) and Cr(III)- Azomethine metal chelates: DNA interaction, Biological Screening and theoretical treatments

2021 ◽  
pp. 131139
Author(s):  
Faizah S. Aljohani ◽  
Ahmed M. Abu-Dief ◽  
Rafat M. El-Khatib ◽  
Hessah A. Al-Abdulkarim ◽  
Arwa Alharbi ◽  
...  
Keyword(s):  
Dna Interaction ◽  
Metal Chelates ◽  
Biological Screening ◽  
Structural Inspection

Tailoring, structural inspection of novel oxy and non-oxy metal-imine chelates for DNA interaction, pharmaceutical and molecular docking studies

Polyhedron ◽  
2021 ◽  
Vol 201 ◽  
pp. 115167
Author(s):  
Mohamed Shaker S. Adam ◽  
Ahmed M. Abu-Dief ◽  
M.M. Makhlouf ◽  
Saad Shaaban ◽  
Seraj O. Alzahrani ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Dna Interaction ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Structural Inspection

Polymer–cobalt(III) complexes: structural analysis of metal chelates on DNA interaction and comparative cytotoxic activity

2013 ◽  
Vol 32 (11) ◽  
pp. 1876-1888 ◽  
Author(s):  
Selvan Nehru ◽  
Sankaralingam Arunachalam ◽  
Renganathan Arun ◽  
Kumpati Premkumar
Keyword(s):  
Structural Analysis ◽  
Cytotoxic Activity ◽  
Dna Interaction ◽  
Metal Chelates

Protamine-DNA interaction

1978 ◽  
Vol 36 (2) ◽  
pp. 200-201
Author(s):  
D.P. Bazett-Jones ◽  
F.P. Ottensmeyer
Keyword(s):  
Small Volume ◽  
Double Helix ◽  
Dna Interaction ◽  
Dark Field ◽  
Sperm Head ◽  
Nuclear Proteins ◽  
Field Electron Microscopy ◽  
Dark Field Electron ◽  
Dna Double Helix ◽  
Positively Charged

Dark field electron microscopy has been used for the study of the structure of individual macromolecules with a resolution to at least the 5Å level. The use of this technique has been extended to the investigation of structure of interacting molecules, particularly the interaction between DNA and fish protamine, a class of basic nuclear proteins of molecular weight 4,000 daltons.Protamine, which is synthesized during spermatogenesis, binds to chromatin, displaces the somatic histones and wraps up the DNA to fit into the small volume of the sperm head. It has been proposed that protamine, existing as an extended polypeptide, winds around the minor groove of the DNA double helix, with protamine's positively-charged arginines lining up with the negatively-charged phosphates of DNA. However, viewing protamine as an extended protein is inconsistent with the results obtained in our laboratory.

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