Controlled release of dopamine coatings on titanium bidirectionally regulate osteoclastic and osteogenic response behaviors

Abstract. Random response is a very common aberrant response behavior in personality tests and may negatively affect the reliability, validity, or other analytical aspects of psychological assessment. Typically, researchers use a single person-fit index to identify random responses. This study recommends a three-step person-fit analysis procedure. Unlike the typical single person-fit methods, the three-step procedure identifies both global misfit and local misfit individuals using different person-fit indices. This procedure was able to identify more local misfit individuals than single-index method, and a graphical method was used to visualize those particular items in which random response behaviors appear. This method may be useful to researchers in that it will provide them with more information about response behaviors, allowing better evaluation of scale administration and development of more plausible explanations. Real data were used in this study instead of simulation data. In order to create real random responses, an experimental test administration was designed. Four different random response samples were produced using this experimental system.

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A New Controlled Release System for Standard 0.052â³ and 0.038â³ Gianturco Coils

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)84371-9 ◽

1998 ◽

Vol 31 (2) ◽

pp. 153A ◽

Cited By ~ 1

Author(s):

C Owada

Keyword(s):

Controlled Release ◽

Release System ◽

Controlled Release System ◽

Gianturco Coils

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Controlled Release of Metformin Hydrochloride I. In vitro Release from Physical Mixture Containing Xanthan Gum as Hydrophilic Rate Retarding Polymer

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v4i1.200 ◽

1970 ◽

Vol 4 (1) ◽

Author(s):

Mashkura Ashrafi ◽

Jakir Ahmed Chowdhury ◽

Md Selim Reza

Keyword(s):

Controlled Release ◽

Xanthan Gum ◽

In Vitro Release ◽

Correlation Coefficients ◽

High Ratio ◽

Water Soluble ◽

Metformin Hydrochloride ◽

Model Drug ◽

Very High

Capsules of different formulations were prepared by using a hydrophilic polymer, xanthan gum and a filler Ludipress. Metformin hydrochloride, which is an anti-diabetic agent, was used as a model drug here with the aim to formulate sustained release capsules. In the first 6 formulations, metformin hydrochloride and xanthan gum were used in different ratio. Later, Ludipress was added to the formulations in a percentage of 8% to 41%. The total procedure was carried out by physical mixing of the ingredients and filling in capsule shells of size 1. As metformin hydrochloride is a highly water soluble drug, the dissolution test was done in 250 ml distilled water in a thermal shaker (Memmert) with a shaking speed of 50 rpm at 370C &plusmn 0.50C for 6 hours. After the dissolution, the data were treated with different kinetic models. The results found from the graphs and data show that the formulations follow the Higuchian release pattern as they showed correlation coefficients greater than 0.99 and the sustaining effect of the formulations was very high when the xanthan gum was used in a very high ratio with the drug. It was also investigated that the Ludipress extended the sustaining effect of the formulation to some extent. But after a certain period, Ludipress did not show any significant effect as the pores made by the xanthan gum network were already blocked. It is found here that when the metformin hydrochloride and the xanthan gum ratio was 1:1, showed a high percentage of drug release, i.e. 91.80% of drug was released after 6 hours. But With a xanthan gum and metformin hydrochloride ratio of 6:1, a very slow release of the drug was obtained. Only 66.68% of the drug was released after 6 hours. The percent loading in this case was 14%. Again, when Ludipress was used in high ratio, it was found to retard the release rate more prominently. Key words: Metformin Hydrochloride, Xanthan Gum, Controlled release capsule Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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