scholarly journals Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1

2021 ◽  
pp. 105340
Author(s):  
Anton N. Shuvaev ◽  
Olga S. Belozor ◽  
Oleg Mozhei ◽  
Dariya A. Yakovleva ◽  
Ilya V. Potapenko ◽  
...  
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Optogenetic Stimulation ◽  
Purkinje Cell Death ◽  
Stimulation Of

PURKINJE CELL DEATH IN TRANSGENIC MICE EXPRESSING AN INTACT OR TRUNCATED FORM OF SV40 T ANTIGEN

1993 ◽  
Vol 52 (3) ◽  
pp. 286
Author(s):  
H. B. Clark ◽  
H. T. Orr ◽  
R. Ehlenfeldt ◽  
W. S. Yunis ◽  
R. M. Feddersen
Keyword(s):  
Cell Death ◽  
Transgenic Mice ◽  
Purkinje Cell ◽  
T Antigen ◽  
Sv40 T Antigen ◽  
Truncated Form ◽  
Purkinje Cell Death

scholarly journals Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease

2015 ◽  
Vol 7 (276) ◽  
pp. 276ra26-276ra26 ◽  
Author(s):  
Charles H. Vite ◽  
Jessica H. Bagel ◽  
Gary P. Swain ◽  
Maria Prociuk ◽  
Tracey U. Sikora ◽  
...  
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Cerebellar Dysfunction ◽  
Purkinje Cell Death ◽  
Niemann Pick

scholarly journals AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease

2017 ◽  
Vol 58 (3) ◽  
pp. 512-518 ◽  
Author(s):  
Chang Xie ◽  
Xue-Min Gong ◽  
Jie Luo ◽  
Bo-Liang Li ◽  
Bao-Liang Song
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Behavioral Abnormalities ◽  
Purkinje Cell Death

scholarly journals Inhibition of Protein Kinase C Prevents Purkinje Cell Death But Does Not Affect Axonal Regeneration

2002 ◽  
Vol 22 (9) ◽  
pp. 3531-3542 ◽  
Author(s):  
Abdel M. Ghoumari ◽  
Rosine Wehrlé ◽  
Chris I. De Zeeuw ◽  
Constantino Sotelo ◽  
Isabelle Dusart
Keyword(s):  
Cell Death ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Purkinje Cell ◽  
Axonal Regeneration ◽  
Kinase C ◽  
Purkinje Cell Death

Neuroprotective effect of nicardipine on cadmium-induced Purkinje cell death in rat cerebellum

2001 ◽  
Vol 29 (2) ◽  
pp. 99-105 ◽  
Author(s):  
Faruk Bağirici ◽  
Hayri Genç ◽  
Faruk Tan ◽  
Şerif Demir
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Neuroprotective Effect ◽  
Rat Cerebellum ◽  
Purkinje Cell Death

scholarly journals Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

2021 ◽  
Author(s):  
Rosa Rademakers ◽  
Alexandra M. Nicholson ◽  
Yingxue Ren ◽  
Shunsuke Koga ◽  
Hung Phuoc Nguyen ◽  
...  
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Motor Deficits ◽  
Purkinje Cell Death

scholarly journals Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Shogo Haraguchi ◽  
Masaki Kamata ◽  
Takuma Tokita ◽  
Kei-ichiro Tashiro ◽  
Miku Sato ◽  
...  
Keyword(s):  
Cell Death ◽  
Purkinje Cell ◽  
Diurnal Variation ◽  
Transcriptional Repression ◽  
Early Life ◽  
Molecular Mechanisms ◽  
Cerebellar Development ◽  
Daily Injection ◽  
Light At Night ◽  
Purkinje Cell Death

The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar Adcyap1 gene that produces PACAP, with subsequent Purkinje cell death. Taken together, pineal ALLO mediated the effect of light on early cerebellar development in chicks.

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