scholarly journals Contribution of phosphorus and PTH to the development of cardiac hypertrophy and fibrosis in an experimental model of chronic renal failure

2022 ◽  
Author(s):  
Laura Martínez-Arias ◽  
Sara Panizo-García ◽  
Julia Martín-Vírgala ◽  
Beatriz Martín-Carro ◽  
Sara Fernández-Villabrille ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiac Hypertrophy ◽  
Experimental Model

Prevention of Cardiac Hypertrophy in Experimental Chronic Renal Failure by Long-Term ACE Inhibitor Administration: Potential Role of Lysosomal Proteinases

1995 ◽  
Vol 15 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Hiroaki Suzuki ◽  
Liliana Schaefer ◽  
Hong Ling ◽  
Roland M. Schaefer ◽  
Jobst Dämmrich ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiac Hypertrophy ◽  
Potential Role ◽  
Ace Inhibitor ◽  
Lysosomal Proteinases

Validation of an Experimental Model to Study Less Severe Chronic Renal Failure

2016 ◽  
Vol 29 (5) ◽  
pp. 309-315 ◽  
Author(s):  
Ida Mária Maximina Fernandes-Charpiot ◽  
Heloisa Cristina Caldas ◽  
Glória Elisa Florido Mendes ◽  
Luiz Gomes de Sá Neto ◽  
Henrique Lacativa Oliveira ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Experimental Model

scholarly journals Contractile responses of urinary bladder in an experimental model of chronic renal failure

2012 ◽  
Vol 12 (4) ◽  
pp. 219 ◽  
Author(s):  
Hüseyin Biçer ◽  
Esat Korgali ◽  
Gökhan Gökçe ◽  
Semih Ayan ◽  
Şahin Yıldırım ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Bladder ◽  
Experimental Model ◽  
Contractile Responses

Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS

2012 ◽  
Vol 413 (5-6) ◽  
pp. 642-649 ◽  
Author(s):  
Ying-Yong Zhao ◽  
Jing Liu ◽  
Xian-Long Cheng ◽  
Xu Bai ◽  
Rui-Chao Lin
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Experimental Model ◽  
Biochemical Changes ◽  
Tof Ms

Renal and Urinary Glycosaminoglycans in an Experimental Model of Chronic Renal Failure in Rats

2000 ◽  
Vol 9 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Yara M. Michelacci ◽  
Ricardo A.M. Cadaval ◽  
Roberto M. Rovigatti ◽  
Oswaldo Kohlman
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Experimental Model ◽  
Urinary Glycosaminoglycans

An experimental model of chronic renal failure in mice

1985 ◽  
Vol 35 (3) ◽  
pp. 276-284 ◽  
Author(s):  
Iain A. Gibb ◽  
David N.H. Hamilton
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Experimental Model

Abstract 1482: Curcumin Attenuates Cardiac Hypertrophy and Left Ventricular Remodeling Secondary to Experimental Chronic Renal Failure Independent of Blood Pressure in Nephrectomized Rats

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Siddartha Ghosh ◽  
Fadi Salloum ◽  
Antonio Abbate ◽  
Stefano Toldo ◽  
Rakesh C Kukreja
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Cardiac Hypertrophy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Positive Control ◽  
Left Ventricular ◽  
Sprague Dawley ◽  
Lv Mass

Background: The prevalence of heart failure (HF) is frequent in patients with chronic renal failure (CRF). One common link between CRF and HF is inflammation. Curcumin, the principal curcuminoid of the Indian curry spice turmeric, is known for its antitumor anti-inflammatory properties. We therefore hypothesized that curcumin would attenuate cardiomyopathy in nephrectomized rats. Methods and Results: Adult Sprague-Dawley rats underwent nephrectomy (Nx) by removal of 5/6 of the kidneys. Four groups were studied for 7 weeks: 1- Control (sham), 2- Nx, 3- Nx + curcumin (75mg/kg; bid), 4- Nx + enalapril (15 mg/kg; bid) as positive control. The systolic blood pressure (SBP, mmHg) of Nx rats was 152±5, significantly higher than control (115±2) and enalapril-treated rats (125±3). Curcumin did not reduce SBP (141±4). BUN (mg/dl) and creatinine (mg/dl) levels of Nx rats (67±7 and 1.92±0.08, respectively) were higher than control (P<0.001). Both curcumin and enalapril significantly reduced BUN (40±2 and 43±4, respectively) and creatinine (0.95±0.05 and 0.77±0.06, respectively) (P<0.001 vs. Nx). Moreover, Nx rats exhibited severe proteinurea (mg/18 hours) (316±36) as compared to controls (34±5) which was blunted by curcumin (183±40, P<0.001) and enalapril (180±17, P<0.001). Right and left cardiac hypertrophy was assessed by weighing the right (RV) and left ventricles (LV) and normalizing with body weight. Nx rats had significant RV and LV hypertrophy (P<0.01). Curcumin and enalapril effectively decreased LV hypertrophy (P<0.05), however, RV hypertrophy was only decreased by curcumin (P<0.05). Echocardiography data revealed a significant increase in LV mass in Nx rats (1.47±0.19) as compared with controls (0.98±0.04, P<0.01). Curcumin and enalapril-treated rats had LV mass of 0.95±0.1 (P<0.01) and 0.93±0.3 (P<0.05), respectively. LV end-diastolic diameter (EDD, mm) was higher in Nx rats (7.2±0.2) as compared to controls (6.4±0.2, P=0.01). Curcumin and enalapril attenuated LV dilatation as shown by EDD of 6.3±0.5 and 6.2±0.5, respectively (P=0.01). Conclusion: These results show that curcumin attenuates cardiac hypertrophy and remodeling in nephrectomized rats independent of BP. Therefore, curcumin may be useful in suppressing HF in patients with CRF.

Kyrle's disease in patients with chronic renal failure

1982 ◽  
Vol 118 (2) ◽  
pp. 85-88 ◽  
Author(s):  
A. F. Hood
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure
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