All-trans retinoic acid enhances bystander effect of suicide-gene therapy against medulloblastomas

2011 ◽  
Vol 503 (2) ◽  
pp. 115-119 ◽  
Author(s):  
Shaoyi Li ◽  
Yun Gao ◽  
Ke Pu ◽  
Li Ma ◽  
Xiaofu Song ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Retinoic Acid ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals All-trans retinoic acid enhances bystander effect of suicide gene therapy in the treatment of breast cancer

2015 ◽  
Vol 35 (3) ◽  
pp. 1868-1874 ◽  
Author(s):  
HENG KONG ◽  
XIA LIU ◽  
LIUCHENG YANG ◽  
KE QI ◽  
HAOYUN ZHANG ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Therapy ◽  
Retinoic Acid ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Cancer suicide gene therapy with TK.007: superior killing efficiency and bystander effect

2011 ◽  
Vol 89 (11) ◽  
pp. 1113-1124 ◽  
Author(s):  
Ellen Preuß ◽  
Alexander Muik ◽  
Kristoffer Weber ◽  
Jürgen Otte ◽  
Dorothee von Laer ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Suicide Gene Therapy

scholarly journals The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy

2000 ◽  
Vol 7 (11) ◽  
pp. 1456-1468 ◽  
Author(s):  
Christine Grignet-Debrus ◽  
Vincent Cool ◽  
Nathalie Baudson ◽  
Thierry Velu ◽  
Claire-Michelle Calberg-Bacq
Keyword(s):  
Gene Therapy ◽  
Herpes Simplex ◽  
Associated Factors ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Varicella Zoster

scholarly journals Suicide gene therapy for plasma cell tumors

Blood ◽  
1996 ◽  
Vol 88 (6) ◽  
pp. 2192-2200 ◽  
Author(s):  
MS Dilber ◽  
MR Abedi ◽  
B Bjorkstrand ◽  
B Christensson ◽  
G Gahrton ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Plasma Cell ◽  
Bystander Effect ◽  
Suicide Gene ◽  
Myeloma Cell ◽  
Scid Mice ◽  
Suicide Gene Therapy ◽  
Mitotic Frequency

Suicide gene therapy for plasma cell tumors was attempted in severe combined immunodeficient (SCID) mice injected with human myeloma cell lines. Initially, a ganciclovir-induced bystander effect was observed in vitro using myeloma cells transduced with a herpes simplex thymidine kinase (HSVtk) gene. Transduced cells injected subcutaneously (SC) into SCID mice could be eradicated by the administration of ganciclovir (GCV). Furthermore, an in vivo bystander effect was noticed when mice received mixtures of HSVtk-positive and nontransduced cells. Unexpectedly, a “distant bystander” effect was observed as tumors in regions inoculated with only nontransduced cells were significantly smaller and had increased frequency of apoptotic figures and decreased mitotic frequency in GCV-treated mice transplanted with HSVtk-positive cells at a different region compared with control mice.

Sign in / Sign up

Export Citation Format

Share Document