Group I metabotropic glutamate receptors modulate late phase long-term potentiation in hippocampal CA1 pyramidal neurons: comparison of apical and basal dendrites

2013 ◽  
Vol 553 ◽  
pp. 132-137 ◽  
Author(s):  
Wei Fan
Keyword(s):  
Metabotropic Glutamate Receptors ◽  
Pyramidal Neurons ◽  
Late Phase ◽  
Long Term Potentiation ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Basal Dendrites ◽  
Term Potentiation ◽  
Hippocampal Ca1

scholarly journals Long-term potentiation in hippocampal oriens interneurons: postsynaptic induction, presynaptic expression and evaluation of candidate retrograde factors

2014 ◽  
Vol 369 (1633) ◽  
pp. 20130133 ◽  
Author(s):  
Elizabeth Nicholson ◽  
Dimitri M. Kullmann
Keyword(s):  
Ampa Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Long Term Potentiation ◽  
Metabotropic Glutamate ◽  
Ca1 Region ◽  
Group I ◽  
Term Potentiation ◽  
Trpv1 Receptors ◽  
Retrograde Signalling

Several types of hippocampal interneurons exhibit a form of long-term potentiation (LTP) that depends on Ca 2+ -permeable AMPA receptors and group I metabotropic glutamate receptors. Several sources of evidence point to a presynaptic locus of LTP maintenance. The retrograde factor that triggers the expression of LTP remains unidentified. Here, we show that trains of action potentials in putative oriens-lacunosum-moleculare interneurons of the mouse CA1 region can induce long-lasting potentiation of stimulus-evoked excitatory postsynaptic currents that mimics LTP elicited by high-frequency afferent stimulation. We further report that blockers of nitric oxide production or TRPV1 receptors failed to prevent LTP induction. The present results add to the evidence that retrograde signalling underlies N -methyl- d -aspartate (NMDA) receptor-independent LTP in oriens interneurons, mediated by an unidentified factor.

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