Effects of fluoxetine on changes of pain sensitivity in chronic stress model rats

2017 ◽  
Vol 651 ◽  
pp. 16-20 ◽  
Author(s):  
Yan-Na Lian ◽  
Jin-Long Chang ◽  
Qi Lu ◽  
Yi Wang ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Pain Sensitivity ◽  
Stress Model

Antidepressant-like effect of trans-resveratrol in chronic stress model: Behavioral and neurochemical evidences

2013 ◽  
Vol 47 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Yingcong Yu ◽  
Rui Wang ◽  
Chunbai Chen ◽  
Xia Du ◽  
Lina Ruan ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Stress Model

scholarly journals Effect of neonatal chronic stress on expression of Hsp70 and oestrogen receptor alpha in the rat oviduct during development and the oestrous cycle

Reproduction ◽  
2003 ◽  
pp. 801-808 ◽  
Author(s):  
ML Mariani ◽  
DR Ciocca ◽  
AS Gonzalez Jatuff ◽  
M Souto
Keyword(s):  
Chronic Stress ◽  
Oestrogen Receptor ◽  
Depressive Disorders ◽  
Adult Life ◽  
Oestrous Cycle ◽  
Stress Model ◽  
Neonatal Development ◽  
Adult Rats ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

A chronic unpredictable stress model used to produce depressive disorders in adult rats was applied to neonatal rats to investigate whether this type of stress can induce changes in the expression of Hsp70 and oestrogen receptor alpha in the oviduct, as detected by immunohistochemistry. Rats stressed during neonatal development showed changes in the expression pattern of Hsp70. In neonatal control rats, Hsp70-positive cells observed in the isthmus did not show any changes. Moreover, rats exposed to this stress model that reached adulthood had higher expression of Hsp70 in the isthmus (P<0.01) but not in the ampulla during oestrus than did the control rats. In contrast, during dioestrus, no significant changes were noted in adult rats that were stressed during neonatal development or in rats that were stressed in adulthood. These findings indicate that the isthmus is very sensitive to stressful stimuli and that repeated pre-weaning stress can change the expression of heat shock proteins in early and adult life. These subtle changes of expression in the oviduct did not affect the fertility of the rats that reached adulthood or that were mated under unstressed conditions. However, the control animals stressed during adulthood showed a disruption of the oestrous cycle: this finding is not observed in rats stressed during neonatal development that show an attenuated oestrous cycle disruption induced by chronic stress in adulthood. Moreover, there was dissociation between the expression of oestrogen receptor alpha and Hsp70. The amount of oestrogen receptor alpha remained constant in the epithelium of the oviduct in the control and in the stressed rats. Expression of oestrogen receptor alpha was noted in the stroma of the oviduct without the concomitant expression of Hsp70. It is possible that in certain cells and tissues Hsp70 is not necessary for oestrogen receptor alpha to be functional or Hsp70 might be present at very low amounts but is sufficient for the receptor to function.

scholarly journals Estrogen re-enhanced prenatal stress-related visceral sensitization and pain regulation

2020 ◽  
Author(s):  
Jinghong Chen ◽  
Ying Sun ◽  
Jinbao Wei ◽  
Peijun Ju ◽  
Qinjie Li ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Prenatal Stress ◽  
Pain Sensitivity ◽  
Visceral Pain ◽  
Afferent Fiber ◽  
Visceral Hypersensitivity ◽  
Female Rats ◽  
Primary Afferent

Abstract Background: Visceral pain is one of the most common sign of irritable bowel syndrome (IBS). Chronic stress during pregnancy may increase visceral pain sensitivity of offspring in a sexdependent way. Combining adult stress in offspring will increase this sensitivity. Based on the evidence implicating estrogen exacerbates visceral hypersensitivity in female rodents in pre-clinical models, we predicted that chronic prenatal stress (CPS) plus chronic adult stress (CAS) will maximize visceral pain sensitivity; and estrogen plays an important role in this hyperalgesia.Methods: The CPS plus CAS rodent model was established in which the balloon was used to distend colorectum. Meanwhile, the single fiber recording in vivo and patch-clamp experiments in vitro were used to monitor neuronal activity. The RT-PCR, Western Blot, and Immunofluorescence were used to study the effects of CPS and CAS on colon primary afferent sensitivity and molecular or transmission changes. We use Ovariectomy and Letrozole to treate female rats respectively in order to assess the role of estrogen in female-specific enhanced primary afferent sensitization. Letrozole mainly used to reduce estrogen levels.Results: As predicted, CPS significantly increased single unit afferent fiber activity in L6-S2 dorsal roots in response. Activity was further enhanced by CAS. And the activity in offspring females was significantly greater than the males. Besides, the excitability of colon-projecting dorsal root ganglion (DRG) neurons increases in CPS + CAS rats that was associated with a decrease in transient A-type K+ current. Letrozole treatment decreases the colon DRG neuron excitability in females by decreasing the estrogen levels. Conclusions: This study adds to the growing evidence for the development of chronic stress induced visceral hypersensitivity in female, which involves estrogen-dependent sensitization of primary afferent colon neurons. Understanding this neurophysiological mechanisms will spur the development of female pain specific therapies.

scholarly journals PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sonali N. Reisinger ◽  
Thomas Wanek ◽  
Oliver Langer ◽  
Daniela D. Pollak
Keyword(s):  
Chronic Stress ◽  
Mouse Brain ◽  
Pet Imaging ◽  
Stress Model ◽  
Dynamic Regulation

Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats

2016 ◽  
Vol 618 ◽  
pp. 31-38 ◽  
Author(s):  
Jun Lu ◽  
Run-Hui Shao ◽  
Li Hu ◽  
Ya Tu ◽  
Jian-You Guo
Keyword(s):  
Chronic Stress ◽  
Stress Model ◽  
Antiinflammatory Effects

Telomere Shortening and Mood Disorders: Preliminary Support for a Chronic Stress Model of Accelerated Aging

2006 ◽  
Vol 60 (5) ◽  
pp. 432-435 ◽  
Author(s):  
Naomi M. Simon ◽  
Jordan W. Smoller ◽  
Kate L. McNamara ◽  
Richard S. Maser ◽  
Alyson K. Zalta ◽  
...  
Keyword(s):  
Mood Disorders ◽  
Chronic Stress ◽  
Accelerated Aging ◽  
Stress Model ◽  
Telomere Shortening ◽  
Preliminary Support

Chronic stress increases pain sensitivity via activation of the rACC–BLA pathway in rats

2019 ◽  
Vol 313 ◽  
pp. 109-123 ◽  
Author(s):  
Ling-Yu Liu ◽  
Rui-Ling Zhang ◽  
Lin Chen ◽  
Hong-Yan Zhao ◽  
Jie Cai ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Pain Sensitivity
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