accelerated aging
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2023 ◽  
Vol 83 ◽  
J. Rubert ◽  
S. H. B. Dornelles ◽  
U. R. Nunes ◽  
N. T. Pedrollo ◽  
M. Peripolli ◽  

Abstract The low Brazilian productive index and the high demand have aroused interest in the cultivation of lentils, however the legume is little known and needs further studies. The objective of this study was to analyze and identify the effects of treatments with insecticides and fungicides on the physiological quality of lentil seeds, CA-1512 strain. The experiments were conducted in the seed laboratory in a completely randomized design with seven treatments and four replicates. Seed treatment with Thiophanate-methyl; Fluazinam® (180 ml) + Pyraclostrobin; Thiophanate-methyl; Fipronil® (150 ml) promoted higher levels of germination under accelerated aging, lower number of abnormal seedlings and longer lengths of shoot and radicle for the emergence in paper. Treatment with Carboxin; Thiram® (250 ml) + Imidacloprid® (150 ml) allowed a higher value in the first count of germination in sand, lower number of dead seeds under accelerated aging and longer root length, in the emergence in sand. Shoot length in the emergence in sand increased after seed treatment with Metalaxyl-M; Fludioxonil® (75 ml) + Pyraclostrobin; Thiophanate-methyl; Fipronil® (150 ml). Treatments with fungicides and insecticides considerably improved the physiological properties of the seeds, thus being able to guarantee greater phytosanitary qualities in the field, generating healthier seedlings and with protection against possible pests and diseases, and consequently guaranteeing greater productivity.

2022 ◽  
Rhiannon M Sears ◽  
Kyle J Roux

Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular processes, including nuclear envelope rupture and repair. BAF localizes to sites of nuclear rupture and recruits NE-repair machinery, including the LEM-domain proteins, ESCRT-III complex, A-type lamins, and membranes. Here, we show that it is a mobile, nucleoplasmic population of A-type lamins that is rapidly recruited to ruptures in a BAF-dependent manner via BAF′s association with the Ig-like β fold domain of A-type lamins. These initially mobile lamins become progressively stabilized at the site of rupture. Farnesylated prelamin A and lamin B1 fail to localize to nuclear ruptures, unless that farnesylation is inhibited. Progeria-associated LMNA mutations inhibit the recruitment affected A-type lamin to nuclear ruptures, due to either permanent farnesylation or inhibition of BAF binding. A progeria-associated BAF mutant targets to nuclear ruptures but is unable to recruit A-type lamins. Together, these data reveal the mechanisms that determine how lamins respond to nuclear ruptures and how progeric mutations of LMNA and BANF1 impair recruitment of A-type lamins to nuclear ruptures.

2022 ◽  
Vol 12 ◽  
Sofie Olund Villumsen ◽  
Rui Benfeitas ◽  
Andreas Dehlbæk Knudsen ◽  
Marco Gelpi ◽  
Julie Høgh ◽  

People living with HIV (PLWH) require life-long anti-retroviral treatment and often present with comorbidities such as metabolic syndrome (MetS). Systematic lipidomic characterization and its association with the metabolism are currently missing. We included 100 PLWH with MetS and 100 without MetS from the Copenhagen Comorbidity in HIV Infection (COCOMO) cohort to examine whether and how lipidome profiles are associated with MetS in PLWH. We combined several standard biostatistical, machine learning, and network analysis techniques to investigate the lipidome systematically and comprehensively and its association with clinical parameters. Additionally, we generated weighted lipid-metabolite networks to understand the relationship between lipidomic profiles with those metabolites associated with MetS in PLWH. The lipidomic dataset consisted of 917 lipid species including 602 glycerolipids, 228 glycerophospholipids, 61 sphingolipids, and 26 steroids. With a consensus approach using four different statistical and machine learning methods, we observed 13 differentially abundant lipids between PLWH without MetS and PLWH with MetS, which mainly belongs to diacylglyceride (DAG, n = 2) and triacylglyceride (TAG, n = 11). The comprehensive network integration of the lipidomics and metabolomics data suggested interactions between specific glycerolipids’ structural composition patterns and key metabolites involved in glutamate metabolism. Further integration of the clinical data with metabolomics and lipidomics resulted in the association of visceral adipose tissue (VAT) and exposure to earlier generations of antiretroviral therapy (ART). Our integrative omics data indicated disruption of glutamate and fatty acid metabolism, suggesting their involvement in the pathogenesis of PLWH with MetS. Alterations in the lipid homeostasis and glutaminolysis need clinical interventions to prevent accelerated aging in PLWH with MetS.

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 238
Alessandro Leparulo ◽  
Marta Bisio ◽  
Nelly Redolfi ◽  
Tullio Pozzan ◽  
Stefano Vassanelli ◽  

For Alzheimer’s disease (AD), aging is the main risk factor, but whether cognitive impairments due to aging resemble early AD deficits is not yet defined. When working with mouse models of AD, the situation is just as complicated, because only a few studies track the progression of the disease at different ages, and most ignore how the aging process affects control mice. In this work, we addressed this problem by comparing the aging process of PS2APP (AD) and wild-type (WT) mice at the level of spontaneous brain electrical activity under anesthesia. Using local field potential recordings, obtained with a linear probe that traverses the posterior parietal cortex and the entire hippocampus, we analyzed how multiple electrical parameters are modified by aging in AD and WT mice. With this approach, we highlighted AD specific features that appear in young AD mice prior to plaque deposition or that are delayed at 12 and 16 months of age. Furthermore, we identified aging characteristics present in WT mice but also occurring prematurely in young AD mice. In short, we found that reduction in the relative power of slow oscillations (SO) and Low/High power imbalance are linked to an AD phenotype at its onset. The loss of SO connectivity and cortico-hippocampal coupling between SO and higher frequencies as well as the increase in UP-state and burst durations are found in young AD and old WT mice. We show evidence that the aging process is accelerated by the mutant PS2 itself and discuss such changes in relation to amyloidosis and gliosis.

2022 ◽  
Vol 13 ◽  
Shixiong Tang ◽  
Zhipeng Wu ◽  
Hengyi Cao ◽  
Xudong Chen ◽  
Guowei Wu ◽  

Major depressive disorder (MDD) is a common psychiatric disorder which is associated with an accelerated biological aging. However, little is known whether such process would be reflected by a more rapid aging of the brain function. In this study, we tested the hypothesis that MDD would be characterized by accelerated aging of the brain’s default-mode network (DMN) functions. Resting-state functional magnetic resonance imaging data of 971 MDD patients and 902 healthy controls (HCs) was analyzed, which was drawn from a publicly accessible, multicenter dataset in China. Strength of functional connectivity (FC) and temporal variability of dynamic functional connectivity (dFC) within the DMN were calculated. Age-related effects on FC/dFC were estimated by linear regression models with age, diagnosis, and diagnosis-by-age interaction as variables of interest, controlling for sex, education, site, and head motion effects. The regression models revealed (1) a significant main effect of age in the predictions of both FC strength and dFC variability; and (2) a significant main effect of diagnosis and a significant diagnosis-by-age interaction in the prediction of FC strength, which was driven by stronger negative correlation between age and FC strength in MDD patients. Our results suggest that (1) both healthy participants and MDD patients experience decrease in DMN FC strength and increase in DMN dFC variability along age; and (2) age-related decrease in DMN FC strength may occur at a faster rate in MDD patients than in HCs. However, further longitudinal studies are still needed to understand the causation between MDD and accelerated aging of brain.

Foods ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 151
Jin Wang ◽  
Jia-Qiang Hu ◽  
Yu-Jie Song ◽  
Jia Yin ◽  
Yuan-Yi-Fei Wang ◽  

The imbalance of reactive oxygen species is the main cause in aging, accompanied by oxidative stress. As the most abundant in human milk oligosaccharides (HMOs), 2′-Fucosyllactose (2′-FL) has been confirmed to have great properties in immunity regulation and anti-inflammatory. The research on 2′-FL is focused on infants currently, while there is no related report of 2′-FL for the elderly. A d-galactose-induced accelerated aging model was established to explore the protective effect of 2′-FL on the intestines and brain in mice. In this study, 2′-FL significantly reduced oxidative stress damage and inflammation in the intestines of aging mice, potentially by regulating the sirtuin1 (SIRT1)-related and nuclear factor E2-related factor 2 (Nrf2) pathways. In addition, 2′-FL significantly improved the gut mucosal barrier function and increased the content of short-chain fatty acids (SCFAs) in the intestine. The gut microbiota analysis indicated that 2′-FL mainly increased the abundance of probiotics like Akkermansia in aging mice. Moreover, 2′-FL significantly inhibited apoptosis in the brains of aging mice, also increasing the expression of SIRT1. These findings provided a basis for learning the benefits of 2′-FL in the aging process.

Florent Gauvin ◽  
Vesta Tsao ◽  
Joost Vette ◽  
Henricus Jozef Hubertus Brouwers

This research aims to study mycelium-based composites (MBC) by assessing their performance as foam-like wall insulation material. Various substrates have been selected to get optimized performance of the composite. Results showed that a prolonged growing period arose a denser mycelium outer layer in MBC, which rendered better water resistance due to the hydrophobicity of mycelium. Thermal conductivity and mechanical properties are highly dependent on substrate choices than other parameters of MBC, which coincided with the literature. Additionally, influences of accelerated aging test and moisture buffer capacity of MBC were first studied in this research. The results indicated that MBC not only maintained good functional performance after the accelerated aging test (i.e. drying and wetting cycles) but also constituted good moisture buffer capacity. This means that MBC has key material essences to apply as internal wall insulation material and become one of the layers in vapor-permeable building envelope systems to passively regulate indoor relative humidity and thermal comfort.

Dmytro Kosiachevskyi ◽  
Kamilia Abahri ◽  
Anne Daubresse ◽  
Evelyne Prat ◽  
Mohend Chaouche

The use of bio-based composites for building insulation is interesting from the point of view of hygrothermal performances, economic and environmental benefits. Among different organic fibers for these materials, hemp is interesting because of its huge availability in France. Nevertheless, the broad application of the hemp-based insulation mortars is hampered due to the lack of a database on their durability. This paper consists of a better understanding of the evolution of the hemp-based composite and its hygrothermal properties. The main objectives are, first, to study the evolution of the hemp insulation mortar microstructure and properties under the accelerated aging cycles, and second, to characterize and analyze the interconnection between observed changes. Experimentally, the protocol of accelerated aging inspired by standardized one was proposed, the microstructural characteristics and the hygrothermal properties, as the total porosity, the thermal conductivity, and the moisture buffer value (MBV) before and after the aging cycles was identified. The MBV characterization was performed for both hemp mortar and hemp shives. The obtained results reveal the increase of the hemp mortar porosity and the decrease of the hemp mortar's thermal conductivity. Furthermore, the MBV value of hemp mortar changes slightly, unlike that of the bulk hemp, which is explained by the mineral matrix's influence. These results consist of data for a better forecast on the degradation of the hemp mortar.

Ferhat Benmahiddine ◽  
Rafik Belarbi

Hemp concrete is one of the most used bio-based materials in the construction industry due to its hygrothermal behaviour and its low environmental footprint. This is mainly due to the complexity of the microstructure of these materials and their highly breathable nature. However, their use remains limited due to the lack of databases and guarantees regarding of the evolution of their functional properties over time. In this paper, experimental investigation has been performed to answer this problematic. The aim is to investigate the influence of accelerated aging on the properties of this material through a succession of immersion/freezing/drying cycles. Materials (aged and reference) were characterized at the same relative humidity state in order to be able to compare the results and to highlight the effect of ageing on the properties of hemp concrete. Results revealed a significant change in the microstructure of this material. As a consequence, this induced significant changes in its hygrothermal and mechanical properties. An increase of 40% in water vapour permeability and decrease of 57% in compressive strength were observed after aging (07 cycles of immersion/freezing/drying).

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