Deregulation of hypothalamic-pituitary-adrenal axis functions in an Alzheimer's disease rat model

2013 ◽  
Vol 34 (5) ◽  
pp. 1426-1439 ◽  
Author(s):  
Anthony Brureau ◽  
Charleine Zussy ◽  
Brice Delair ◽  
Charline Ogier ◽  
Guy Ixart ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Stress-Induced Neurodegeneration: The Potential for Coping as Neuroprotective Therapy

2020 ◽  
Vol 35 ◽  
pp. 153331752096087
Author(s):  
Shelby A. Kline ◽  
Michael S. Mega
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Mineralocorticoid Receptor ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Receptor Expression ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Neuroprotective Therapy ◽  
Pituitary Adrenal Axis

Stress responses are essential for survival, but become detrimental to health and cognition with chronic activation. Chronic hypothalamic-pituitary-adrenal axis release of glucocorticoids induces hypothalamic-pituitary-adrenal axis dysfunction and neuronal loss, decreases learning and memory, and modifies glucocorticoid receptor/mineralocorticoid receptor expression. Elderly who report increased stress are nearly 3 times more likely to develop Alzheimer’s disease, have decreased global cognition and faster cognitive decline than those reporting no stress. Patients with mild cognitive impairment are more sensitive to stress compared to healthy elderly and those with Alzheimer’s disease. Stress may also transduce neurodegeneration via the gut microbiome. Coping styles determine hippocampal mineralocorticoid receptor expression in mice, indicating that coping modifies cortisol’s effect on the brain. Identifying neuroprotective coping strategies that lessen the burden of stress may prevent or slow cognitive decline. Treatments and education designed to reduce stress should be recognized as neuroprotective.

The predictive value of hypothalamic-pituitary-adrenal axis dysfunction in Alzheimer's disease

1996 ◽  
Vol 39 (11) ◽  
pp. 976-978 ◽  
Author(s):  
Gregory R.J. Swanwick ◽  
Robert F. Coen ◽  
J. Bernard Walsh ◽  
Davis Coakley ◽  
Brian A. Lawlor
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Predictive Value ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis
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