Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons

Neuroscience ◽  
2009 ◽  
Vol 160 (2) ◽  
pp. 484-491 ◽  
Author(s):  
S. Moriguchi ◽  
X. Zhao ◽  
W. Marszalec ◽  
J.Z. Yeh ◽  
K. Fukunaga ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Nicotinic Acetylcholine Receptors ◽  
Cortical Neurons ◽  
Acetylcholine Receptors ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Inhibitory Synaptic Transmission ◽  
Rat Cortical Neurons ◽  
Stimulation Of

Modulation of Neuronal Nicotinic Acetylcholine Receptors by Halothane in Rat Cortical Neurons

2001 ◽  
Vol 59 (4) ◽  
pp. 732-743 ◽  
Author(s):  
Takashi Mori ◽  
Xilong Zhao ◽  
Yi Zuo ◽  
Gary L. Aistrup ◽  
Kiyonobu Nishikawa ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Cortical Neurons ◽  
Acetylcholine Receptors ◽  
Neuronal Nicotinic Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Rat Cortical Neurons

scholarly journals Nicotinic modulation of Ca2+ oscillations in rat cortical neurons in vitro

2016 ◽  
Vol 310 (9) ◽  
pp. C748-C754 ◽  
Author(s):  
JianGang Wang ◽  
YaLi Wang ◽  
FangLi Guo ◽  
ZhiBo Feng ◽  
XiangFang Wang ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Cortical Neurons ◽  
Oscillation Frequency ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Cultured Cortical Neurons ◽  
Intracellular Ca ◽  
Rat Cortical Neurons ◽  
20 Nm

The roles of nicotine on Ca2+ oscillations [intracellular Ca2+ ([Ca2+]i) oscillation] in rat primary cultured cortical neurons were studied. The spontaneous [Ca2+]i oscillations (SCO) were recorded in a portion of the neurons (65%) cultured for 7–10 days in vitro. Application of nicotine enhanced [Ca2+]i oscillation frequency and amplitude, which were reduced by the selective α4β2-nicotinic acetylcholine receptors (nAChRs) antagonist dihydro-β-erythroidine (DHβE) hydrobromide, and the selective α7-nAChRs antagonist methyllycaconitine citrate (MLA, 20 nM). DHβE reduced SCO frequency and prevented the nicotinic increase in the frequency. DHβE somewhat enhanced SCO amplitude and prevented nicotinic increase in the amplitude. MLA (20 nM) itself reduced SCO frequency without affecting the amplitude but blocked nicotinic increase in [Ca2+]i oscillation frequency and amplitude. Furthermore, coadministration of both α4β2- and α7-nAChRs antagonists completely prevented nicotinic increment in [Ca2+]i oscillation frequency and amplitude. Thus, our results indicate that both α4β2- and α7-nAChRs mediated nicotine-induced [Ca2+]i oscillations, and two nAChR subtypes differentially regulated SCO.

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