scholarly journals Selenoprotein expression is essential in endothelial cell development and cardiac muscle function

2007 ◽  
Vol 17 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Rajeev K. Shrimali ◽  
James A. Weaver ◽  
Georgina F. Miller ◽  
Matthew F. Starost ◽  
Bradley A. Carlson ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cardiac Muscle ◽  
Muscle Function ◽  
Cell Development

scholarly journals Contributions of Ca 2+ -Independent Thin Filament Activation to Cardiac Muscle Function

2015 ◽  
Vol 109 (10) ◽  
pp. 2101-2112 ◽  
Author(s):  
Yasser Aboelkassem ◽  
Jordan A. Bonilla ◽  
Kimberly J. McCabe ◽  
Stuart G. Campbell
Keyword(s):  
Cardiac Muscle ◽  
Muscle Function ◽  
Thin Filament ◽  
Filament Activation

Cardiac Muscle Function Studies

1971 ◽  
pp. 105-123 ◽  
Author(s):  
William W. Parmley ◽  
Edmund H. Sonnenblick
Keyword(s):  
Cardiac Muscle ◽  
Muscle Function

Intersection of regulatory pathways controlling hemostasis and hemochorial placentation

2021 ◽  
Vol 118 (50) ◽  
pp. e2111267118
Author(s):  
Masanaga Muto ◽  
Damayanti Chakraborty ◽  
Kaela M. Varberg ◽  
Ayelen Moreno-Irusta ◽  
Khursheed Iqbal ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Differentiation ◽  
Cell Invasion ◽  
Cell Development ◽  
Trophoblast Cell ◽  
Extravillous Trophoblast ◽  
Cell Phenotype ◽  
Trophoblast Cells ◽  
Rat Models ◽  
Endovascular Trophoblast

Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling trophoblast cell development. TS cell differentiation was characterized by acquisition of transcript signatures indicative of an endothelial cell-like phenotype, which was highlighted by the expression of anticoagulation factors including tissue factor pathway inhibitor (TFPI). TFPI localized to invasive endovascular trophoblast cells of the rat placentation site. Disruption of TFPI in rat TS cells interfered with development of the endothelial cell-like endovascular trophoblast cell phenotype. Similarly, TFPI was expressed in human invasive/extravillous trophoblast (EVT) cells situated within first-trimester human placental tissues and following differentiation of human TS cells. TFPI was required for human TS cell differentiation to EVT cells. We next investigated the physiological relevance of TFPI at the placentation site. Genome-edited global TFPI loss-of-function rat models revealed critical roles for TFPI in embryonic development, resulting in homogeneous midgestation lethality prohibiting analysis of the role of TFPI as a regulator of the late-gestation wave of intrauterine trophoblast cell invasion. In vivo trophoblast-specific TFPI knockdown was compatible with pregnancy but had profound effects at the uterine–placental interface, including restriction of the depth of intrauterine trophoblast cell invasion while leading to the accumulation of natural killer cells and increased fibrin deposition. Collectively, the experimentation implicates TFPI as a conserved regulator of invasive/EVT cell development, uterine spiral artery remodeling, and hemostasis at the maternal–fetal interface.

scholarly journals Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8976 ◽  
Author(s):  
Christopher F. Spurney ◽  
Hee-Jae Cha ◽  
Arpana Sali ◽  
Gouri S. Pandey ◽  
Emidio Pistilli ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Muscle Function ◽  
Chronic Administration ◽  
Deficient Mouse

The Adaptive Intracellular Control of Cardiac Muscle Function

2004 ◽  
Vol 1015 (1) ◽  
pp. 71-83 ◽  
Author(s):  
AMIR LANDESBERG ◽  
CARMIT LEVY ◽  
YAEL YANIV ◽  
SAMUEL SIDEMAN
Keyword(s):  
Cardiac Muscle ◽  
Muscle Function
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