Effects of long-term eteplirsen treatment on upper limb function in patients with Duchenne muscular dystrophy: findings of two phase 2 clinical trials

2017 ◽  
Vol 27 ◽  
pp. S216
Author(s):  
L. Alfano ◽  
K. Berry ◽  
J. Mendell ◽  
H. Eliopoulos ◽  
L. Han ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
Phase 2 ◽  
Limb Function ◽  
Two Phase ◽  
Upper Limb Function ◽  
Phase 2 Clinical Trials

scholarly journals Upper limb function in Duchenne muscular dystrophy: 24 month longitudinal data

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0199223 ◽  
Author(s):  
Marika Pane ◽  
Giorgia Coratti ◽  
Claudia Brogna ◽  
Elena Stacy Mazzone ◽  
Anna Mayhew ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Longitudinal Data ◽  
Upper Limb ◽  
Limb Function ◽  
Upper Limb Function

scholarly journals RESPONSIVENESS OF UPPER LIMB SCALES AND TRUNK CONTROL FOR THE EVOLUTION OF PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY

2021 ◽  
Vol 39 ◽  
Author(s):  
Flaviana Kelly de Lima Maciel ◽  
Ana Lúcia Yaeko da Silva Santos ◽  
Cristina dos Santos Cardoso de Sá
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
Repeated Measures ◽  
Comparison Method ◽  
Time Effect ◽  
Initial Assessment ◽  
Trunk Control ◽  
Limb Function ◽  
Upper Limb Function

ABSTRACT Objective: To verify the interval of responsiveness to the scales Segmental Assessment of Trunk Control (SATCo-BR), Performance of Upper Limbs (PUL), and Jebsen Taylor Test (JTT) in patients with Duchenne Muscular Dystrophy (DMD). Methods: We assessed patients with DMD aged 6 to 19 years old and with mini-mental (MMSE) score above 10 points. The assessments were performed individually, in a single session. The upper limb function was performed by PUL and JTT, and trunk control by SATCo-BR. Assessments were repeated six and 12 months after the initial assessment. The repeated-measures analysis of variance model and Bonferroni’s multiple comparison method were employed as post hoc analysis; when the ANOVA assumptions were not met, the Friedman test was applied. Results: The sample consisted of 28 patients evaluated in three moments (initial, and six and 12 months after the beginning). There was a time effect for the Upper Limb function performance in the total JTT, and for the subtests, except for subtests 1 and 6, which did not show a difference between the different moments. There was also a time effect for the score of total PUL, proximal PUL, intermediate PUL, and distal PUL. In the SATCo-BR, this effect was observed between the initial and 6 months, and between the initial and 12 months. Conclusions: The JTT, PUL, and SATCo-BR scales can detect changes over time, and they showed responsiveness to detect the evolution of the disease in the 6-month interval.

scholarly journals Upper limb function in adults with Duchenne muscular dystrophy

2011 ◽  
Vol 43 (9) ◽  
pp. 770-775 ◽  
Author(s):  
RF Pangalila ◽  
B Bartels ◽  
MP Bergen ◽  
NAM Cobben ◽  
HJ Stam ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
Limb Function ◽  
Upper Limb Function

scholarly journals International workshop on assessment of upper limb function in Duchenne Muscular Dystrophy

2012 ◽  
Vol 22 (11) ◽  
pp. 1025-1028 ◽  
Author(s):  
Eugenio Mercuri ◽  
Craig McDonald ◽  
Anna Mayhew ◽  
Julaine Florence ◽  
Elena Mazzone ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
International Workshop ◽  
Limb Function ◽  
Upper Limb Function

Trunk Control and Upper Limb Function of Walking and Non-walking Duchenne Muscular Dystrophy Individuals.

2021 ◽  
pp. 1-7
Author(s):  
Ana Lucia Yaeko da Silva Santos ◽  
Flaviana Kelly de Lima Maciel ◽  
Francis Meire Fávero ◽  
Luis Fernando Grossklauss ◽  
Cristina dos Santos Cardoso de Sá
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
Trunk Control ◽  
Limb Function ◽  
Upper Limb Function

scholarly journals Upper limb function and activity in people with facioscapulohumeral muscular dystrophy: a web-based survey

2016 ◽  
Vol 39 (3) ◽  
pp. 236-243 ◽  
Author(s):  
Arjen Bergsma ◽  
Edith H. C. Cup ◽  
Mariska M. H. P. Janssen ◽  
Alexander C. H. Geurts ◽  
Imelda J. M. de Groot
Keyword(s):  
Muscular Dystrophy ◽  
Upper Limb ◽  
Facioscapulohumeral Muscular Dystrophy ◽  
Limb Function ◽  
Web Based ◽  
Upper Limb Function
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