Cognitive impairment and its associated factors among HIV/AIDS patients on anti retro -viral therapy in Sub-Saharan Africa: Systematic review and meta-analysis

Abstract Background In the developing world, such as the sub-Saharan African region, HIV/AIDS has worsened the impact of under-nutrition in children. HIV infected children are highly vulnerable to under-nutrition. Therefore, the objective of this systematic review and meta-analysis was to estimate the pooled prevalence of under-nutrition, and the pooled effect sizes of associated factors among HIV-infected children in sub-Saharan Africa. Methods The primary studies for this review were retrieved from PubMed/ MEDLINE online, Science Direct, Hinari, web of science, CINHAL, EMBASE, WHO databases, Google, and Google Scholar databases. The articles selected for this meta-analysis were published between 2010 and 2020. The last search date was 18 October 2021. The data was extracted in Microsoft Excel format and exported to STATA Version 14.0. A random effect meta-analysis model was used. Heterogeneity was evaluated by the I2 test. The Egger weighted regression test was used to assess publication bias. Results We retrieved 847 records from these databases. Of which records, 813 were excluded due to different reasons and 34 studies were included in the final analysis. The pooled prevalence of stunting, underweight and wasting in HIV infected children was 46.7% (95% CI; 40.36–53.07, I2 = 98.7%, p < 0.01), 35.9% (95% CI; 30.79–41.02, I2 = 97.4% p < 0.01), and 23.0% (95% CI; 18.67–27.42, I2 = 96.9%, p < 0.01) respectively. The advanced WHO HIV/AIDS clinical staging (III&IV) [OR = 6.74 (95%: 1.747, 26.021), I2 = 94.7%] and household food insecurity were associated with stunting [OR = 5.92 (95% CI 3.9, 8.87), I2 = 55.7%]. Low family economic status [OR = 4.737 (95% CI: 2.605, 8.614), I2 = 31.2%] and increased feeding frequency [OR = 0.323 (95% CI: 0.172, 0.605), I2 = 69.8%] were significantly associated with under-weight. Anemia [OR = 2.860 (95% CI: 1.636, 5.000), I2 = 74.8%] and diarrhea in the previous month [OR = 4.117 (95% CI: 2.876, 5.894), I2 = 0.0%] were also associated with wasting among HIV infected children in sub-Saharan Africa. Conclusions The pooled prevalence of under-nutrition among HIV infected children was high. Nutritional assessment and interventions need great attention as a part of HIV care for HIV positive children. The implementation of policies and strategies established by national and international stakeholders in ART care centres should take a maximum emphasis on reducing under-nutrition among HIV infected children.

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Prevalence of Cryptosporidium species among HIV/AIDS patients in Sub Saharan Africa; Systematic Review and Meta-Analysis

Journal of HIV for Clinical and Scientific Research ◽

10.17352/2455-3786.000030 ◽

2020 ◽

Vol 7 (1) ◽

pp. 006-012

Author(s):

Awulachew Ephrem ◽

Diriba Kuma ◽

Gemede Aschalew ◽

Wudneh Feven

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Cryptosporidium Species ◽

Sub Saharan Africa ◽

Aids Patients ◽

Sub Saharan ◽

Hiv Aids

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Epidemiology of malaria among HIV/AIDS patients in sub-Saharan Africa: A systematic review and meta-analysis of observational studies

Acta Tropica ◽

10.1016/j.actatropica.2020.105798 ◽

2021 ◽

Vol 215 ◽

pp. 105798

Author(s):

Oluwasola Olaiya Obebe ◽

Olufarati Oludunsin Falohun

Keyword(s):

Systematic Review ◽

Observational Studies ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Aids Patients ◽

Sub Saharan ◽

Hiv Aids

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Alcohol consumption and its associated factors among pregnant women in Sub-Saharan Africa: a systematic review and meta-analysis' as given in the submission system

Substance Abuse Treatment Prevention and Policy ◽

10.1186/s13011-020-00269-3 ◽

2020 ◽

Vol 15 (1) ◽

Cited By ~ 1

Author(s):

Alemu Earsido Addila ◽

Telake Azale Bisetegn ◽

Yigzaw Kebede Gete ◽

Mezgebu Yitayal Mengistu ◽

Getnet Mihretie Beyene

Keyword(s):

Systematic Review ◽

Alcohol Consumption ◽

Alcohol Use ◽

Pregnant Women ◽

Associated Factors ◽

Unplanned Pregnancy ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Pooled Prevalence ◽

Sub Saharan

Abstract Background Alcohol consumption during pregnancy represents a significant public health concern. It has several adverse health effects for both the mother and the developing fetus. This study aimed to estimate the pooled prevalence and the effect size of associated factors of alcohol consumption during pregnancy in Sub-Saharan Africa countries. Methods The results of the review were reported based on the Preferred Reporting Items for Systematic Review and Meta-Analysis statement (PRISMA) guideline and, it was registered in the Prospero database, number CRD42019127103. The available primary studies were collated from different databases: PubMed, CINAHL, Cochrane Library, PsycINFO, Google Scholar, African Journals Online and Centre for Addiction and Mental Health Library. The main search terms were [((alcohol consumption) OR (alcohol drinking) OR (alcohol use) OR (ethanol use) OR (alcohol exposure)) AND ((pregnant women) OR (pregnant mother) OR (during pregnancy)) AND (Sub-Saharan Africa)]. We used the Joanna Briggs Institute (JBI) for critical appraisal of studies. The random-effects model was computed to estimate the pooled prevalence. Heterogeneity between studies was checked using the I2 statistic and the Cochrane Q test. Results The review resulted in 963 original studies after searching various databases, and finally 37 studies in qualitative synthesis and 30 articles in the systematic review and meta-analysis were included. The overall summary estimate of the prevalence of alcohol consumption during pregnancy was found to be 20.83% (95% CI: 18.21, 23.46). The pooled estimate of meta-analysis showed that depression (OR: 1.572; 95% CI: 1.34, 1.845), partners’ alcohol use (OR: 1.32, 95% CI: 1.11, 1.57), knowledge on harmful effect of alcohol consumption (OR: 0.36, 95% CI: 0.29, 0.45) and, unplanned pregnancy (OR: 2.33, 95% CI: 1.17, 4.63) were statistically significant factors with alcohol consumption during pregnancy. Conclusions The result showed that there was high alcohol consumption during pregnancy in Sub- Saharan Africa. Alcohol consumption during pregnancy was associated with depression, partners’ alcohol use, unplanned pregnancy and knowledge of the harmful effects of alcohol consumption. Therefore, this will be a basis for public policy and resource allocation for prevention initiatives.

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Alcohol Use and Antiretroviral Therapy Non-Adherence Among Adults Living with HIV/AIDS in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

AIDS and Behavior ◽

10.1007/s10461-019-02716-0 ◽

2019 ◽

Vol 24 (6) ◽

pp. 1727-1742 ◽

Cited By ~ 3

Author(s):

Jennifer Velloza ◽

Christopher G. Kemp ◽

Frances M. Aunon ◽

Megan K. Ramaiya ◽

Emma Creegan ◽

...

Keyword(s):

Systematic Review ◽

Antiretroviral Therapy ◽

Alcohol Use ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Sub Saharan ◽

Living With Hiv ◽

Hiv Aids

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Unsafe abortion and associated factors among reproductive aged women in Sub-Saharan Africa: a protocol for a systematic review and meta-analysis

Systematic Reviews ◽

10.1186/s13643-018-0775-9 ◽

2018 ◽

Vol 7 (1) ◽

Cited By ~ 9

Author(s):

Merhawi Gebremedhin ◽

Agumasie Semahegn ◽

Tofik Usmael ◽

Gezahegn Tesfaye

Keyword(s):

Systematic Review ◽

Associated Factors ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Unsafe Abortion ◽

Sub Saharan ◽

Reproductive Aged Women

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Magnitude of depression and associated factors among patients with tuberculosis in sub-Saharan Africa: A systematic review and meta-analysis.

Journal of Affective Disorders Reports ◽

10.1016/j.jadr.2021.100080 ◽

2021 ◽

Vol 4 ◽

pp. 100080

Author(s):

Haile Amha ◽

Henok Mulugeta ◽

Asmamaw Getnet ◽

Dessalegn Haile ◽

Keralem Anteneh ◽

...

Keyword(s):

Systematic Review ◽

Associated Factors ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Sub Saharan

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Prevalence of school absenteeism during menstruation and associated factors in sub-Saharan Africa: A systematic review and meta-analysis protocol

10.21203/rs.3.rs-415160/v1 ◽

2021 ◽

Author(s):

Amerti Gelo ◽

Melake Damena ◽

Ayele Geleto ◽

Abera Kenay

Keyword(s):

Systematic Review ◽

Associated Factors ◽

Meta Analysis ◽

Female Students ◽

Sub Saharan Africa ◽

School Absenteeism ◽

Menstrual Hygiene ◽

Menstrual Hygiene Management ◽

Hygiene Management ◽

Sub Saharan

Abstract Background: Although menstruation is a normal physiological process, it could affect several females’ daily activities. In most low resource settings, where menstrual hygiene management is poor and several schools have no water supply and separate toilet for female students, most school girls miss classes during menstruation. With the emergence of studies on menstrual hygiene management, it is evident that pooling several pocket studies is essential to draw lessons about effects of menstruation on female students’ class participation. Therefore, the aim of this review is to systematically assess the prevalence of school absenteeism and associated factors during menstruation among high school students in sub-Saharan Africa.Methods: The protocol for this systematic review was registered in PROSPERO (ID CRD42020223447). Electronic databases such as MEDLINE, CINAHL, Embase, Web of Science, Scopus and Google Scholar will be searched for published articles using appropriate key terms. The identified articles will be assessed for meeting the eligibility criteria such as being published in English, conducted in sub-Saharan Africa, contain information on school absenteeism, and conducted in schools. Two reviewers will independently screen the identified articles using titles and abstracts followed by full text review of all potential articles. The quality of the included papers will be assessed using the adapted Newcastle-Ottawa Scale for cross-sectional studies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist will be employed to present the findings. Quantitative findings will be pooled using random effect meta-analysis model while the qualitative findings will be presented using narrative synthesis.Discussion: Analysis of existing evidence of school absenteeism during menstruation is essential for designing appropriate interventions in school and beyond. This review will present credible information that would help in designing evidence-based menstrual hygiene management for improving school attendance during menstruation in sub-Saharan Africa where more than half of female students miss classes during menstruation.Systematic review registration: PROSPERO CRD42020223447

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Prevalence of Electrocardiographic Abnormalities Among People Living With HIV/AIDS in Sub-saharan Africa: Protocol for a Systematic Review and Meta-analysis

10.21203/rs.3.rs-743165/v1 ◽

2021 ◽

Author(s):

Andrew Weil M Semulimi ◽

Andrew Peter Kyazze ◽

John Mukisa ◽

Charles Batte ◽

Felix Bongomin

Keyword(s):

Systematic Review ◽

Cardiovascular Diseases ◽

Meta Analysis ◽

Sub Saharan Africa ◽

Cochrane Library ◽

People Living With Hiv ◽

Sub Saharan ◽

Living With Hiv ◽

Ecg Abnormalities ◽

Hiv Aids

Abstract IntroductionElectrocardiographic (ECG) abnormalities are highly prevalent among people living with HIV/AIDS (PLWHA) contributing to the rising burden of cardiovascular diseases among this population. Sub-Saharan Africa (SSA) contributes more than two thirds to the global burden of HIV/AIDS. However, an accurate account of the prevalence of ECG abnormalities in SSA is unknown. This study aims to determine the prevalence of ECG abnormalities among PLWHA in Sub-Saharan Africa. Methods and analysisA systematic review and meta-analysis will be conducted. Databases including EMBASE, MEDLINE, African Journal Online and The Cochrane Library (Cochrane Central Register of Controlled Trials (CENTRAL), and Cochrane Methodology Register) will be used to search for studies published between 1st January 2000 and 31st December 2020. Studies reporting any form of ECG abnormalities will be considered. Additionally, articles in both English and French will be reviewed. Articles will be screened and reviewed by two independent reviewers to determine their eligibility and any disagreement will be resolved through discussions with fourth and fifth reviewer. Eligibility of the studies will be assessed and judged based on the pre-set criteria. Retrieved studies will be assessed for validity using the Cochrane risk of bias tool and the modified Newcastle Ottawa Scale by two reviewers. Analysis of proportions will be done using STATA MP Version 16.0. A p<0.05 will be considered statistically significant.DiscussionIn the face of a growing burden of cardiovascular diseases among PLWHA, this study will provide an estimate of ECG abnormalities among PLWHA which will emphasize the importance of ECGs in screening for cardiovascular diseases in this population.Systematic review registration numberCRD42021243664.

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