scholarly journals Prevalence of Electrocardiographic Abnormalities Among People Living With HIV/AIDS in Sub-saharan Africa: Protocol for a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Andrew Weil M Semulimi ◽  
Andrew Peter Kyazze ◽  
John Mukisa ◽  
Charles Batte ◽  
Felix Bongomin
Keyword(s):  
Systematic Review ◽  
Cardiovascular Diseases ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
Cochrane Library ◽  
People Living With Hiv ◽  
Sub Saharan ◽  
Living With Hiv ◽  
Ecg Abnormalities ◽  
Hiv Aids

Abstract IntroductionElectrocardiographic (ECG) abnormalities are highly prevalent among people living with HIV/AIDS (PLWHA) contributing to the rising burden of cardiovascular diseases among this population. Sub-Saharan Africa (SSA) contributes more than two thirds to the global burden of HIV/AIDS. However, an accurate account of the prevalence of ECG abnormalities in SSA is unknown. This study aims to determine the prevalence of ECG abnormalities among PLWHA in Sub-Saharan Africa. Methods and analysisA systematic review and meta-analysis will be conducted. Databases including EMBASE, MEDLINE, African Journal Online and The Cochrane Library (Cochrane Central Register of Controlled Trials (CENTRAL), and Cochrane Methodology Register) will be used to search for studies published between 1st January 2000 and 31st December 2020. Studies reporting any form of ECG abnormalities will be considered. Additionally, articles in both English and French will be reviewed. Articles will be screened and reviewed by two independent reviewers to determine their eligibility and any disagreement will be resolved through discussions with fourth and fifth reviewer. Eligibility of the studies will be assessed and judged based on the pre-set criteria. Retrieved studies will be assessed for validity using the Cochrane risk of bias tool and the modified Newcastle Ottawa Scale by two reviewers. Analysis of proportions will be done using STATA MP Version 16.0. A p<0.05 will be considered statistically significant.DiscussionIn the face of a growing burden of cardiovascular diseases among PLWHA, this study will provide an estimate of ECG abnormalities among PLWHA which will emphasize the importance of ECGs in screening for cardiovascular diseases in this population.Systematic review registration numberCRD42021243664.

scholarly journals Alcohol Use and Antiretroviral Therapy Non-Adherence Among Adults Living with HIV/AIDS in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 24 (6) ◽  
pp. 1727-1742 ◽  
Author(s):  
Jennifer Velloza ◽  
Christopher G. Kemp ◽  
Frances M. Aunon ◽  
Megan K. Ramaiya ◽  
Emma Creegan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antiretroviral Therapy ◽  
Alcohol Use ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
Sub Saharan ◽  
Living With Hiv ◽  
Hiv Aids

scholarly journals Epidemiology of multimorbidity among people living with HIV in sub-Saharan Africa: a systematic review protocol

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e036988
Author(s):  
Kelechi Elizabeth Oladimeji ◽  
Armstrong Dzomba ◽  
Olatunji Adetokunboh ◽  
Lindiwe Zungu ◽  
Sanni Yaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quality Assessment ◽  
Observational Studies ◽  
Sub Saharan Africa ◽  
Current Status ◽  
Cochrane Library ◽  
Forest Plot ◽  
People Living With Hiv ◽  
Sub Saharan ◽  
Living With Hiv

IntroductionSub-Saharan Africa remains the epicentre of the HIV pandemic, yet enormous knowledge gaps still exist to elicit a comprehensive portrait of multimorbidity and HIV linkage. This study aims to conduct a systematic meta-analysis of peer-reviewed literature to investigate the current status of multimorbidity epidemiology among people living with HIV (PLHIV) in sub-Saharan Africa.Methods and analysisOur review will assess observational studies (ie, cohort, case–control and cross-sectional) on multimorbidity associated with HIV/AIDS between 1 January 2005 and 31 October 2020 from sub-Saharan Africa. Databases to be searched include PubMed/MEDLINE, Scopus, Web of Science, Cochrane library, African Index Medicus and African Journals Online. We will also search the WHO clinical trial registry and databases for systematic reviews. The search strategy will involve the use of medical subject headings and key terms to obtain studies on the phenomena of HIV and multimorbidity at high precision. Quality assessment of eligible studies will be ascertained using a validated quality assessment tool for observational studies and risk of bias through sensitivity analysis to identify publication bias. Further, data on characteristics of the study population, multimorbid conditions, epidemiological rates and spatial distribution of multimorbid conditions in PLHIV will be extracted. Heterogeneity of individual studies will be evaluated using the I2 statistic from combined effect size estimates. The statistical analysis will be performed using STATA statistical software V.15 and results will be graphically represented on a forest plot.Ethics and disseminationEthical approval is not applicable in this study as it is a systematic review of published literature. The review findings may also be presented at conferences or before other relevant stakeholders.PROSPERO registration numberCRD42020148668.

scholarly journals Sexual Behaviour, Needs and Concerns Regarding Sexual and Reproductive Health among Adults Living with HIV in Sub-Saharan Africa- A Systematic Review

2021 ◽  
pp. 113-132
Author(s):  
Ifeoma Chinyere Ofurum
Keyword(s):  
Systematic Review ◽  
Reproductive Health ◽  
Sexual Behaviour ◽  
Sexual And Reproductive Health ◽  
Meta Analysis ◽  
Sub Saharan Africa ◽  
People Living With Hiv ◽  
Infected People ◽  
Sub Saharan ◽  
Living With Hiv

Background:  The sexual and reproductive health of people living with HIV in sub-Saharan Africa should be of paramount importance and, therefore, given the attention it deserves. The advent of antiretroviral therapy (ART) and subsequent access to it has aided millions of infected people to live a normal life. However, being on ART is not enough as most of these people despite being on the therapy are faced with needs and concerns that have shaped their sexual behaviour. This review aims to bring to perspective the sexual behaviour, needs, and concerns regarding the sexual and reproductive health of adults living with HIV in sub-Saharan Africa (SSA) with a view to reducing the disease's ultimate burden in the region. Method: An extensive search of articles was carried out using the reporting systematic review and meta-analysis (PRISMA). The database search was from JSTORE, Scopus, Google Scholar, Medline, Cochrane, Semantic scholar, and Pubmed. Results: A total of 3,984 results were obtained from the search. The application of the inclusion and exclusion criteria finally gave ten studies which were reviewed. The review revealed, among other things, that a good number of adults living with HIV have multiple sex partners, and some still have sex without condoms. Besides, most of them indicated the need for their own biological children, especially after being on ART for a while. Some women living with HIV in SSA do not have a right to decide on their sexual and reproductive health. Recommendation: It was recommended that there be intense re-orientation and health education for this group of people. Women need to be empowered and taught their rights.

scholarly journals Stigmatising Attitudes Towards Co-workers with HIV in the Workplace of a Metropolitan State, Southwestern Nigeria

2017 ◽  
Vol 11 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Idongesit Godwin Utuk ◽  
Kayode Omoniyi Osungbade ◽  
Taiwo Akinyode Obembe ◽  
David Ayobami Adewole ◽  
Victoria Oluwabunmi Oladoyin
Keyword(s):  
Sampling Technique ◽  
Sub Saharan Africa ◽  
Good Knowledge ◽  
People Living With Hiv ◽  
Cross Sectional Survey ◽  
Southwestern Nigeria ◽  
Cross Sectional ◽  
Sub Saharan ◽  
Living With Hiv ◽  
Hiv Aids

Background:Despite demonstrating global concerns about infection in the workplace, very little research has explored how co-workers react to those living with HIV in the workplace in sub-Saharan Africa. This study aimed to assess the level of stigmatising attitude towards co-workers living with HIV in the workplace.Methods:The study was a descriptive cross-sectional survey involving 403 respondents. They were recruited from selected companies through a multistage sampling technique. Survey was carried out using pre-tested semi-structured questionnaires. Data were analyzed using the Statistical Package for the Social Sciences to generate frequencies, cross tabulations of variables at 5% level of significance. Logistic regression model was used to determine the predictors at 95% confidence intervals.Results:Mean age of respondents was 32.9 ± 9.4 years with 86.1% being females. Overall, slightly below two-third (63.0%) had good knowledge on transmission of HIV/AIDS while 218 (54.1%) respondents had a high stigmatising attitude towards co-workers with HIV in the workplace. More female respondents (69.6%) demonstrated high stigmatising attitudes towards co-workers with HIV in the workplace (p = 0.012). Female workers were twice more likely to have high stigmatising attitudes towards co-worker with HIV [OR 2.1 (95% CI: 1.13 – 3.83)].Conclusion:Stigma towards people living with HIV/AIDs is still very persistent in different settings. Good knowledge amongst our participants about HIV/AIDs did not translate to low stigmatising attitudes among workers. Concerted efforts and trainings on the transmission of HIV/AIDs are essential to reduce stigma that is still very prevalent in workplace settings.

scholarly journals Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Khalid Eltom ◽  
Khalid Enan ◽  
Abdel Rahim M. El Hussein ◽  
Isam M. Elkhidir
Keyword(s):  
Systematic Review ◽  
Dengue Virus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Denv Infection ◽  
Sub Saharan Africa ◽  
Cochrane Library ◽  
The Past ◽  
Sub Saharan ◽  
Infection Markers

Dengue virus (DENV) infection has garnered a global interest in the past few decades. Nevertheless, its epidemiology in certain developing and low-income regions remains poorly understood, due to the absence of comprehensive surveillance and reporting systems. This systematic review and meta-analysis aimed to determine the prevalence of DENV infection in the population of Sub-Saharan Africa using DENV infection markers, and to track any changes in its prevalence during the past ten years. It was conducted in accordance with the PRISMA guidelines, targeting the literature available at MEDLINE/PubMed, ScienceDirect, Cochrane library and Google Scholar. All articles published in English language between January 2010 and June 2020 were screened for eligibility. Random effects model was used to calculate the pooled prevalence of all infection markers. The Inconsistency Index (I2) was used to assess the level of heterogeneity between studies. Subgroup analysis according to country and time-frame of studies was conducted to provide possible explanations to substantial heterogeneity. The critical appraisal tool for prevalence studies designed by the Joanna Briggs Institute (JBI) was used to assess the risk of bias in all included studies. A total of 84 articles, covering 21 countries, were included in this review. Quantitative meta-analysis estimated a pooled IgG prevalence of 25% (95% CI: 21-29%, I2 = 99%), a pooled IgM prevalence of 10% (95% CI: 9-11%, I2 = 98%) and a pooled DENV RNA prevalence of 14% (95% CI: 12-16%, I2 = 99%). Evidence for possible publication bias was also found in all three meta-analyses. Subgroup analysis according to the time of sample collection was performed to closely track the changing prevalence of DENV infection markers between 2010 and 2019. This meta-analysis estimates a high prevalence of DENV infection in Sub-Saharan Africa. More cost-efficient vector control strategies should be designed and implemented in order to adapt to the low-resource nature of this region.

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