Developmental hypothyroidism reduces the expression of activity-dependent plasticity genes in dentate gyrus of the adult following long-term potentiation

2014 ◽  
Vol 43 ◽  
pp. 94-95
Author(s):  
M. Gilbert ◽  
K. Sanchez-Huerta ◽  
Wood C.
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Dependent Plasticity ◽  
Term Potentiation ◽  
Activity Dependent

scholarly journals Long-term potentiation in the dentate gyrus of the anaesthetized rat is accompanied by an increase in extracellular glutamate: real-time measurements using a novel dialysis electrode

2003 ◽  
Vol 358 (1432) ◽  
pp. 675-687 ◽  
Author(s):  
M. L. Errington ◽  
P. T. Galley ◽  
T. V. P. Bliss
Keyword(s):  
Dentate Gyrus ◽  
Real Time ◽  
Low Frequency ◽  
Long Term Potentiation ◽  
Perforant Path ◽  
Extracellular Glutamate ◽  
Term Potentiation ◽  
Frequency Stimulation ◽  
Activity Dependent

We have used a glutamate-specific dialysis electrode to obtain real-time measurements of changes in the concentration of glutamate in the extracellular space of the hippocampus during low-frequency stimulation and following the induction of long-term potentiation (LTP). In the dentate gyrus, stimulation of the perforant path at 2 Hz for 2 min produced a transient increase in glutamate current relative to the basal value at control rates of stimulation (0.033 Hz). This activity-dependent glutamate current was significantly enhanced 35 and 90 min after the induction of LTP. The maximal 2 Hz signal was obtained during post-tetanic potentiation (PTP). There was also a more gradual increase in the basal level of extracellular glutamate following the induction of LTP. Both the basal and activity-dependent increases in glutamate current induced by tetanic stimulation were blocked by local infusion of the N -methyl-D-aspartate receptor antagonist D-APV. In areas CA1 and CA3 we were unable to detect a 2 Hz glutamate signal either before or after the induction of LTP, possibly owing to a more avid uptake of glutamate in the pyramidal cell fields. These results demonstrate that LTP in the dentate gyrus is associated with a greater concentration of extracellular glutamate following activation of potentiated synapses, either because potentiated synapses release more transmitter per impulse, or because of reduced uptake by glutamate transporters. We present arguments favouring increased release rather than decreased uptake.

Spine formation pattern of new neurons is modulated by induction of long-term potentiation (LTP) in adult dentate gyrus

2009 ◽  
Vol 65 ◽  
pp. S83
Author(s):  
Noriaki Ohkawa ◽  
Yoshito Saitoh ◽  
Eri Tokunaga ◽  
Toshio Kitamura ◽  
Kaoru Inokuchi
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Spine Formation ◽  
Term Potentiation ◽  
Formation Pattern

Spatial performance correlates with long-term potentiation of the dentate gyrus but not of the CA1 region in rats with fimbria–fornix lesions

2001 ◽  
Vol 307 (3) ◽  
pp. 159-162 ◽  
Author(s):  
Kazuhito Nakao ◽  
Yuji Ikegaya ◽  
Maki K Yamada ◽  
Nobuyoshi Nishiyama ◽  
Norio Matsuki
Keyword(s):  
Dentate Gyrus ◽  
Long Term Potentiation ◽  
Ca1 Region ◽  
Term Potentiation ◽  
Spatial Performance

The Vertical Lobe of Cephalopods

2017 ◽  
pp. 558-574 ◽  
Author(s):  
Ana Turchetti-Maia ◽  
Tal Shomrat ◽  
Binyamin Hochner
Keyword(s):  
Complex Networks ◽  
Long Term Potentiation ◽  
Learning Networks ◽  
Neuronal Circuitry ◽  
Cellular Processes ◽  
Term Potentiation ◽  
Matrix Organization ◽  
Activity Dependent ◽  
Similar Organization

We show that the cephalopod vertical lobe (VL) is a promising system for assessing the function and organization of the neuronal circuitry mediating complex learning and memory behavior. Studies in octopus and cuttlefish VL networks suggest an independent evolutionary convergence into a matrix organization of a divergence-convergence (“fan-out fan-in”) network with activity-dependent long-term plasticity mechanisms. These studies also show, however, that the properties of the neurons, neurotransmitters, neuromodulators, and mechanisms of induction and maintenance of long-term potentiation are different from those evolved in vertebrates and other invertebrates, and even highly variable among these two cephalopod species. This suggests that complex networks may have evolved independently multiple times and that, even though memory and learning networks share similar organization and cellular processes, there are many molecular ways of constructing them.

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