3.14Improved Quantification of Thallium-201 Left Ventricular Volumes from Dual-isotope Myocardial Perfusion SPECT Using an Energy-Based Scatter Correction

2007 ◽  
Vol 14 (4) ◽  
pp. S109-S109
Author(s):  
K SAHA ◽  
S CULLOM ◽  
J CASE ◽  
S COURTER ◽  
T BATEMAN ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Scatter Correction ◽  
Myocardial Perfusion Spect ◽  
Left Ventricular ◽  
Thallium 201 ◽  
Left Ventricular Volumes ◽  
Ventricular Volumes ◽  
Dual Isotope ◽  
Perfusion Spect

scholarly journals Optimisation of Simultaneous Tl-201/Tc-99m Dual Isotope Reconstruction with Monte-Carlo-Based Scatter Correction

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Tuija Kangasmaa ◽  
Jyrki Kuikka ◽  
Antti Sohlberg
Keyword(s):  
Monte Carlo ◽  
Myocardial Perfusion ◽  
Scatter Correction ◽  
Reconstruction Algorithm ◽  
Myocardial Perfusion Spect ◽  
Energy Window ◽  
Dual Isotope ◽  
Expectation Maximisation ◽  
Perfusion Spect

Simultaneous Tl-201/Tc-99m dual isotope myocardial perfusion SPECT is seriously hampered by down-scatter from Tc-99m into the Tl-201 energy window. This paper presents and optimises the ordered-subsets-expectation-maximisation-(OS-EM-) based reconstruction algorithm, which corrects the down-scatter using an efficient Monte Carlo (MC) simulator. The algorithm starts by first reconstructing the Tc-99m image with attenuation, collimator response, and MC-based scatter correction. The reconstructed Tc-99m image is then used as an input for an efficient MC-based down-scatter simulation of Tc-99m photons into the Tl-201 window. This down-scatter estimate is finally used in the Tl-201 reconstruction to correct the crosstalk between the two isotopes. The mathematical 4D NCAT phantom and physical cardiac phantoms were used to optimise the number of OS-EM iterations where the scatter estimate is updated and the number of MC simulated photons. The results showed that two scatter update iterations and 105 simulated photons are enough for the Tc-99m and Tl-201 reconstructions, whereas 106 simulated photons are needed to generate good quality down-scatter estimates. With these parameters, the entire Tl-201/Tc-99m dual isotope reconstruction can be accomplished in less than 3 minutes.

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