Potential of [11C]TMSX for the evaluation of adenosine A2A receptors in the skeletal muscle by positron emission tomography

2004 ◽  
Vol 31 (7) ◽  
pp. 949-956 ◽  
Author(s):  
Kiichi Ishiwata ◽  
Masaki Mizuno ◽  
Yuichi Kimura ◽  
Kazunori Kawamura ◽  
Keiichi Oda ◽  
...  
2003 ◽  
Vol 17 (3) ◽  
pp. 205-211 ◽  
Author(s):  
Kiichi Ishiwata ◽  
Wei-Fang Wang ◽  
Yuichi Kimura ◽  
Kazunori Kawamura ◽  
Kenji Ishii

Synapse ◽  
2004 ◽  
Vol 55 (2) ◽  
pp. 133-136 ◽  
Author(s):  
Kiichi Ishiwata ◽  
Masahiro Mishina ◽  
Yuichi Kimura ◽  
Keiichi Oda ◽  
Toru Sasaki ◽  
...  

2000 ◽  
Vol 27 (6) ◽  
pp. 541-546 ◽  
Author(s):  
Wei-Fang Wang ◽  
Kiichi Ishiwata ◽  
Hiromi Nonaka ◽  
Shin-ichi Ishii ◽  
Motohiro Kiyosawa ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Meng-Juan Sun ◽  
Fang Liu ◽  
Ya-Fei Zhao ◽  
Xiao-Ai Wu

As an invasive nuclear medical imaging technology, positron emission tomography (PET) possess the possibility to imaging the distribution as well as the density of selective receptors via specific PET tracers. Inspired by PET, the development of radio-chemistry has greatly promoted the progress of innovative imaging PET tracers for adenosine receptors, in particular adenosine A2A receptors (A2ARs). PET imaging of A2A receptors play import roles in the research of adenosine related disorders. Several radio-tracers for A2A receptors imaging have been evaluated in human studies. This paper reviews the recent research progress of PET tracers for A2A receptors imaging, and their applications in the diagnosis and treatment of related disease, such as cardiovascular diseases, autoimmune diseases, neurodegenerative and psychiatric disease. The future development of A2A PET tracers were also discussed.


2006 ◽  
Vol 34 (5) ◽  
pp. 679-687 ◽  
Author(s):  
Mika Naganawa ◽  
Yuichi Kimura ◽  
Masahiro Mishina ◽  
Yoshitsugu Manabe ◽  
Kunihiro Chihara ◽  
...  

2009 ◽  
Vol 107 (2) ◽  
pp. 599-604 ◽  
Author(s):  
Yuichi Gondoh ◽  
Manabu Tashiro ◽  
Masatoshi Itoh ◽  
Mohammad M. Masud ◽  
Hiroomi Sensui ◽  
...  

Skeletal muscle glucose uptake closely reflects muscle activity at exercise intensity levels <55% of maximal oxygen consumption (V̇o2max). Our purpose was to evaluate individual skeletal muscle activity from glucose uptake in humans during pedaling exercise at different workloads by using [18F]fluorodeoxyglucose (FDG) and positron emission tomography (PET). Twenty healthy male subjects were divided into two groups (7 exercise subjects and 13 control subjects). Exercise subjects were studied during 35 min of pedaling exercise at 40 and 55% V̇o2max exercise intensities. FDG was injected 10 min after the start of exercise or after 20 min of rest. PET scanning of the whole body was conducted after completion of the exercise or rest period. In exercise subjects, mean FDG uptake [standardized uptake ratio (SUR)] of the iliacus muscle and muscles of the anterior part of the thigh was significantly greater than uptake in muscles of control subjects. At 55% V̇o2max exercise, SURs of the iliacus muscle and thigh muscles, except for the rectus femoris, increased significantly compared with SURs at 40% V̇o2max exercise. Our results are the first to clarify that the iliacus muscle, as well as the muscles of the anterior thigh, is the prime muscle used during pedaling exercise. In addition, the iliacus muscle and all muscles in the thigh, except for the rectus femoris, contribute when the workload of the pedaling exercise increases from 40 to 55% V̇o2max.


2021 ◽  
Author(s):  
Tomoyuki Kanayama ◽  
Junsuke Nakase ◽  
Takafumi Mochizuki ◽  
Kazuki Asai ◽  
Rikuto Yoshimizu ◽  
...  

Abstract The foot exercises “rock-paper-scissors” and “towel gathering” are widely used in patients with lower limb disorders; however, there are no detailed reports on muscle activity during such training. We quantitatively evaluated the difference in skeletal muscle activity between the two exercises using positron emission tomography. Eight university student athletes were included. Four participants each were assigned to the foot rock-paper-scissors and towel gathering groups. Participants in each group underwent continuous training for 15 min. They received an intravenous injection of 18F-fluorodeoxyglucose and retrained for 15 min, following which they rested for 45 min. Regions of interest were defined in 25 muscles. The standardized uptake value (SUV) in the trained limb was compared with that in the non-trained control limb. SUVs increased in four skeletal muscles (tibialis anterior, peroneus brevis, extensor hallucis brevis, and abductor hallucis) in the rock-paper-scissors group, and in four muscles (flexor digitorum longus, extensor hallucis brevis, extensor digitorum brevis, and quadratus plantae) in the towel gathering group. Thus, foot rock-paper-scissors and towel gathering affected skeletal muscles related to the medial longitudinal arch and toe grip strength, respectively. Given that the two exercises target different skeletal muscles, they should be taught and implemented according to their respective purposes.


2001 ◽  
Vol 25 (4) ◽  
pp. 306-312
Author(s):  
Tajinder P. Singh ◽  
Kevin Greer ◽  
Otto Muzik ◽  
Robert L. Hammond ◽  
Larry W. Stephenson ◽  
...  

IUBMB Life ◽  
2001 ◽  
Vol 52 (6) ◽  
pp. 279-284 ◽  
Author(s):  
David E. Kelley ◽  
Julie C. Price ◽  
Claudio Cobelli

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