Functional interaction between the orexin-1 and CB1 receptors within the nucleus accumbens in the conditioned place preference induced by the lateral hypothalamus stimulation

2015 ◽  
Vol 132 ◽  
pp. 42-48 ◽  
Author(s):  
Zahra Fatahi ◽  
Nasim Assar ◽  
Dorna Mahmoudi ◽  
Pouyan Pahlevani ◽  
Marzieh Moradi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Lateral Hypothalamus ◽  
Place Preference ◽  
Cb1 Receptors ◽  
Functional Interaction

Melanin-concentrating hormone in rat nucleus accumbens or lateral hypothalamus differentially impacts morphine and food seeking behaviors

2020 ◽  
Vol 34 (4) ◽  
pp. 478-489 ◽  
Author(s):  
Dongmei Wang ◽  
Jianjun Zhang ◽  
Yunjing Bai ◽  
Xigeng Zheng ◽  
Mirmohammadali M Alizamini ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Lateral Hypothalamus ◽  
Drugs Of Abuse ◽  
Inhibitory Effect ◽  
Place Preference ◽  
Sprague Dawley ◽  
Nucleus Accumbens Shell ◽  
Melanin Concentrating Hormone ◽  
Natural Rewards

Background: Identifying neural substrates that are differentially affected by drugs of abuse and natural rewards is key to finding a target for an efficacious treatment for substance abuse. Melanin-concentrating hormone is a polypeptide with an inhibitory effect on the mesolimbic dopamine system. Here we test the hypothesis that melanin-concentrating hormone in the lateral hypothalamus and nucleus accumbens shell is differentially involved in the regulation of morphine and food-rewarded behaviors. Methods: Male Sprague–Dawley rats were trained with morphine (5.0 mg/kg, subcutaneously) or food pellets (standard chow, 10–14 g) to induce a conditioned place preference, immediately followed by extinction training. Melanin-concentrating hormone (1.0 µg/side) or saline was infused into the nucleus accumbens shell or lateral hypothalamus before the reinstatement primed by morphine or food, and locomotor activity was simultaneously monitored. As the comparison, melanin-concentrating hormone was also microinjected into the nucleus accumbens shell or lateral hypothalamus before the expression of food or morphine-induced conditioned place preference. Results: Microinfusion of melanin-concentrating hormone into the nucleus accumbens shell (but not into the lateral hypothalamus) prevented the reinstatement of morphine conditioned place preference but had no effect on the reinstatement of food conditioned place preference. In contrast, microinfusion of melanin-concentrating hormone into the lateral hypothalamus (but not in the nucleus accumbens shell) inhibited the reinstatement of food conditioned place preference but had no effect on the reinstatement of morphine conditioned place preference. Conclusions: These results suggest a clear double dissociation of melanin-concentrating hormone in morphine/food rewarding behaviors and melanin-concentrating hormone in the nucleus accumbens shell. Melanin-concentrating hormone could be a potential target for therapeutic intervention for morphine abuse without affecting natural rewards.

Functional interaction between morphine and central amygdala cannabinoid CB1 receptors in the acquisition and expression of conditioned place preference

2011 ◽  
Vol 220 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Ameneh Rezayof ◽  
Maryam Sardari ◽  
Mohammad-Reza Zarrindast ◽  
Touraj Nayer-Nouri
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Cb1 Receptors ◽  
Central Amygdala ◽  
Functional Interaction

Involvement of dopaminergic receptors of the rat nucleus accumbens in decreasing the conditioned place preference induced by lateral hypothalamus stimulation

2013 ◽  
Vol 556 ◽  
pp. 10-14 ◽  
Author(s):  
Abbas Haghparast ◽  
Alireza Omranifard ◽  
Reza Arezoomandan ◽  
Mohadeseh Ghalandari-Shamami ◽  
Zahra Taslimi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Lateral Hypothalamus ◽  
Place Preference ◽  
Dopaminergic Receptors ◽  
Rat Nucleus Accumbens

Blockage of acquisition and expression of morphine-induced conditioned place preference in rats due to activation of glutamate receptors type II/III in nucleus accumbens

2015 ◽  
Vol 135 ◽  
pp. 192-198 ◽  
Author(s):  
Negar Baharlouei ◽  
Abdolrahman Sarihi ◽  
Alireza Komaki ◽  
Siamak Shahidi ◽  
Abbas Haghparast
Keyword(s):  
Nucleus Accumbens ◽  
Glutamate Receptors ◽  
Conditioned Place Preference ◽  
Place Preference ◽  
Type Ii

Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: Role of enkephalin in the nucleus accumbens

2010 ◽  
Vol 58 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Jing Liang ◽  
Xing-Jie Ping ◽  
Yi-Jing Li ◽  
Yao-Ying Ma ◽  
Liu-Zhen Wu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats

PsyCh Journal ◽  
2012 ◽  
Vol 1 (1) ◽  
pp. 2-14 ◽  
Author(s):  
Jun Gao ◽  
Ning Zhu ◽  
Min Feng ◽  
Xiaolu Meng ◽  
Nan Sui
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference

scholarly journals Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference

2009 ◽  
Vol 34 (8) ◽  
pp. 1993-2001 ◽  
Author(s):  
Darlene H Brunzell ◽  
Yann S Mineur ◽  
Rachael L Neve ◽  
Marina R Picciotto
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Place Preference
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