This work is focused on the synthesis and characterization of versatile acrylate polymer of chalcone
based triazine for their antibacterial activity and cumulative drug release behaviour studies. The novel
acrylate monomer 4-(3-(4-((4-(4-(3-(4-((7-chloroquinolin-4-yl)amino)-phenyl)-3-oxoprop-1-en-1-
yl)phenoxy)-6-((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)oxy)phenyl)-3-oxoprop-1-en-1-
yl)phenylacrylate (SCP) is from novel chalcone and acryloyl chloride. Homo and copolymers of SCP
were prepared using acrylic acid and hydroxyethyl acrylate. Physical characterization confirms the
formation of the above compounds. Prepared drug molecules possess chalcone moiety as well as
quinoline so it has the greater effect to inhibit the growth of the Gram-negative bacteria (15.63 ± 0.4
μg/mL) was confirmed by MIC method. The weight average molecular weight of the polymer is
10,000 g/mol. The polymer decomposes at 325 ºC. Drug releasing in vitro behaviour of the synthesized
drug is controlled by the nature of comonomer, pH and the temperature.
Antimicrobial and Drug Releasing Studies of Novel Acrylate Polymer based on Triazine