Cytokeratin-positive epithelioid gastrointestinal stromal tumor of the stomach – A comment on “Gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation”

2013 ◽  
Vol 209 (7) ◽  
pp. 467-468 ◽  
Author(s):  
Ekkehard Hewer ◽  
Vera Genitsch ◽  
Stephan C. Schäfer ◽  
Istvan Vajtai
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Neuroendocrine Differentiation ◽  
Undifferentiated Carcinoma ◽  
Stromal Tumor

Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor

2020 ◽  
Vol 46 ◽  
pp. 151527
Author(s):  
Bohuslava Vankova ◽  
Kristyna Behenska ◽  
Meret Bauer ◽  
Monika Sedivcova ◽  
Magdalena Daumova ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Stromal Tumor ◽  
Undifferentiated Carcinoma ◽  
Morphological Features ◽  
Stromal Tumor

scholarly journals Gastric carcinoma with a gastrointestinal stromal tumor

2018 ◽  
Vol 34 ◽  
pp. 15-19
Author(s):  
Sen Liu ◽  
Hongyu Liu ◽  
Yunlong Dong ◽  
Fengbiao Wang ◽  
Huijuan Wang ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Gastrointestinal Stromal Tumor ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Neuroendocrine Differentiation ◽  
Tp53 Gene ◽  
Gastric Fundus ◽  
Gastric Antrum ◽  
Stromal Tumor ◽  
Sequencing Analysis

Gastric carcinoma (GC) with gastrointestinal stromal tumor (GIST) is encountered very rarely in the clinic, and few cases have been reported in the literature. Here, we present a case involving a 72-year-old man who was diagnosed with gastric antrum adenocarcinoma accompanied by neuroendocrine differentiation and a GIST in the fundus, according to a preoperative examination and postoperative pathology. The patient then underwent a distal radical gastrectomy and GIST resection. After the operation, the patient was administered combined chemo-radiotherapy and subsequently underwent a 9-month follow-up examination. The gene mutations involved in this case were explored via high-throughput sequencing. The high-throughput gene mutation analysis indicated an exon5 mutation in the TP53 gene and copy number amplification of FGF19, CCND1, and FGFR2 in the gastric antrum adenocarcinoma. A gene sequencing analysis of the gastric fundus stromal tumor demonstrated an exon11 non-frame shift deletion mutation in the KIT gene. These findings suggested that this patient’s cancer might be sensitive to AZD1775 (a TP53-targeted drug) or targeted drugs such as FGF19, CCND1 and FGFR2, and should be sensitive to imatinib.

scholarly journals A Case of Gastric Undifferentiated Carcinoma Originally Diagnosed as Gastrointestinal Stromal Tumor

2014 ◽  
Vol 75 (2) ◽  
pp. 403-408 ◽  
Author(s):  
Kenji KURODA ◽  
Hiroaki TANAKA ◽  
Masaichi OHIRA ◽  
Chie SAKIMURA ◽  
Kazuya MUGURUMA ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Undifferentiated Carcinoma ◽  
Stromal Tumor
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