scholarly journals Single-institution clinical experience using Robust Intensity Modulated Proton Therapy in chordoma and chondrosarcoma of the mobile spine and sacrum: feasibility and need for plan adaptation

2021 ◽  
Author(s):  
Michiel Kroesen ◽  
Vesna Miladinovic ◽  
Stefan A.J. Hutschemaekers ◽  
Jenneke Jacobs ◽  
Charlotte van der Vos ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Proton Therapy ◽  
Single Institution ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Mobile Spine ◽  
Plan Adaptation

Initial clinical experience of postmastectomy intensity modulated proton therapy in patients with breast expanders with metallic ports

2017 ◽  
Vol 7 (4) ◽  
pp. e243-e252 ◽  
Author(s):  
Robert W. Mutter ◽  
Nicholas B. Remmes ◽  
Mohamed MH Kahila ◽  
Kathy A. Hoeft ◽  
Deanna H. Pafundi ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Initial Clinical Experience

Intensity Modulated Proton Therapy for Head-and-Neck Cancer: The First Clinical Experience

2012 ◽  
Vol 84 (3) ◽  
pp. S475-S476 ◽  
Author(s):  
S.J. Frank ◽  
J.D. Cox ◽  
M. Gillin ◽  
D.I. Rosenthal ◽  
A.S. Garden ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Clinical Experience ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

scholarly journals Early Clinical Outcomes of Intensity Modulated Radiation Therapy/Intensity Modulated Proton Therapy Combination in Comparison with Intensity Modulated Radiation Therapy Alone in Oropharynx Cancer Patients

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1549
Author(s):  
Han Gyul Yoon ◽  
Yong Chan Ahn ◽  
Dongryul Oh ◽  
Jae Myoung Noh ◽  
Seung Gyu Park ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Combination Group ◽  
Intensity Modulated Proton Therapy ◽  
Oropharynx Cancer ◽  
Intensity Modulated ◽  
Before And After ◽  
Grade 3 ◽  
Early Clinical Outcomes

Purpose: To report the early clinical outcomes of combining intensity-modulated radiation therapy (IMRT) and intensity-modulated proton therapy (IMPT) in comparison with IMRT alone in treating oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center, were retrospectively reviewed. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fractions were either by IMRT in 81 patients (IMRT only) or by IMPT in 67 (IMRT/IMPT combination), respectively, based on comparison of adaptive re-plan profiles and availability of equipment. Propensity-score matching (PSM) was done on 76 patients (38 from each group) for comparative analyses. Results: With the median follow-up of 24.7 months, there was no significant difference in overall survival and progression free survival between groups, both before and after PSM. Before PSM, the IMRT/IMPT combination group experienced grade ≥ 3 acute toxicities less frequently: mucositis in 37.0% and 13.4% (p < 0.001); and analgesic quantification algorithm (AQA) in 37.0% and 19.4% (p = 0.019), respectively. The same trends were observed after PSM: mucositis in 39.5% and 15.8% (p = 0.021); and AQA in 47.4% and 21.1% (p = 0.016), respectively. In multivariate logistic regression, grade ≥ 3 mucositis was significantly less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.027 and 0.024, respectively). AQA score ≥ 3 was also less frequent in the IMRT/IMPT combination group, both before and after PSM (p = 0.085 and 0.018, respectively). Conclusions: In treating the OPC patients, with comparable early oncologic outcomes, more favorable acute toxicity profiles were achieved following IMRT/IMPT combination than IMRT alone.

scholarly journals Multiple Computed Tomography Robust Optimization to Account for Random Anatomic Density Variations During Intensity Modulated Proton Therapy

2020 ◽  
Vol 5 (5) ◽  
pp. 1022-1031 ◽  
Author(s):  
Mingyao Zhu ◽  
Adeel Kaiser ◽  
Mark V. Mishra ◽  
Young Kwok ◽  
Jill Remick ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Robust Optimization ◽  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated
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