Point-spread-function enhancement via designing new configuration of collimator in nuclear medicine

2022 ◽  
Vol 190 ◽  
pp. 109783
Author(s):  
Mansour Ashoor ◽  
Abdollah Khorshidi
2021 ◽  
Author(s):  
Mansour Ashoor ◽  
Abdollah Khorshidi

Abstract Objective: The collimators in which the various geometrical configurations have been suggested to optimize the sensitivity and resolution have a key role in acquiring the qualified images in nuclear medicine towards a better recognition of some diseases. Methods: In this study, a new configuration as a geometrical combination of the conical, cylindrical and spherical (CCS) volumes for parallel hole collimators which is assessed by using the volumetric-parametric method has been introduced to improve point spread function (PSF) being the collimators response on the radioactive point source. It has been simulated by the MCNPX code at the various energies values of the point source along with the traditional collimator in which included the cylindrical volume only. Results: The PSF will transmogrify from a delta function to a distribution which can correlate with a Gaussian distribution, while the scattered gamma rays were increased. The simulation results have indicated that the PSF in the CCS configuration is narrower than that of the cylindrical one at all the energies, leading the improvement of the resolution. Also, the theoretical results are agreement with the simulated ones. The more the energy value of the source, the more broaden the PSF will be due the more penetration strength. The narrower the PSF, the better the qualified image will be. Conclusion: This method may be employed to determine the accurate attenuation coefficient of absorbers as well.


2013 ◽  
Vol 26 (11) ◽  
pp. 944-952 ◽  
Author(s):  
Huibin Wang ◽  
Rong Zhang ◽  
Zhe Chen ◽  
Lizhong Xu ◽  
Jie Shen

2020 ◽  
Vol 128 (7) ◽  
pp. 1036-1040 ◽  
Author(s):  
N. G. Stsepuro ◽  
G. K. Krasin ◽  
M. S. Kovalev ◽  
V. N. Pestereva

2014 ◽  
Author(s):  
Jingyu Yang ◽  
Bin Jiang ◽  
Jinlong Ma ◽  
Yi Sun ◽  
Ming Di

2005 ◽  
Vol 52 (12) ◽  
pp. 1695-1728 ◽  
Author(s):  
C. Van der Avoort * ◽  
J. J. M. Braat ◽  
P. Dirksen ◽  
A. J. E. M. Janssen

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 665
Author(s):  
Wajahat Khatri ◽  
Hyun Woo Chung ◽  
Rudolf A. Werner ◽  
Jeffrey P. Leal ◽  
Kenneth J. Pienta ◽  
...  

Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is emerging as an important modality for imaging patients with prostate cancer (PCa). As with any imaging modality, indeterminate findings will arise. The PSMA reporting and data system (PSMA-RADS) version 1.0 codifies indeterminate soft tissue findings with the PSMA-RADS-3A moniker. We investigated the role of point-spread function (PSF) reconstructions on categorization of PSMA-RADS-3A lesions. Methods: This was a post hoc analysis of an institutional review board approved prospective trial. Around 60 min after the administration of 333 MBq (9 mCi) of PSMA-targeted 18F-DCFPyL, patients underwent PET/computed tomography (CT) acquisitions from the mid-thighs to the skull vertex. The PET data were reconstructed with and without PSF. Scans were categorized according to PSMA-RADS version 1.0, and all PSMA-RADS-3A lesions on non-PSF images were re-evaluated to determine if any could be re-categorized as PSMA-RADS-4. The maximum standardized uptake values (SUVs) of the lesions, mean SUVs of blood pool, and the ratios of those values were determined. Results: A total of 171 PSMA-RADS-3A lesions were identified in 30 patients for whom both PSF reconstructions and cross-sectional imaging follow-up were available. A total of 13/171 (7.6%) were re-categorized as PSMA-RADS-4 lesions with PSF reconstructions. A total of 112/171 (65.5%) were found on follow-up to be true positive for PCa, with all 13 of the re-categorized lesions being true positive on follow-up. The lesions that were re-categorized trended towards having higher SUVmax-lesion and SUVmax-lesion/SUVmean-blood-pool metrics, although these relationships were not statistically significant. Conclusions: The use of PSF reconstructions for 18F-DCFPyL PET can allow the appropriate re-categorization of a small number of indeterminate PSMA-RADS-3A soft tissue lesions as more definitive PSMA-RADS-4 lesions. The routine use of PSF reconstructions for PSMA-targeted PET may be of value at those sites that utilize this technology.


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