Hypertrophic pachymeningitis in a patient with ANCA negative granulomatosis with polyangiitis: A case report

2020 ◽  
Vol 27 (4) ◽  
pp. 291-297
Author(s):  
Jorge Huaringa-Marcelo ◽  
Rubén Kevin Arnold Tapia-Orihuela ◽  
David Loja-Oropeza
Keyword(s):  
Case Report ◽  
Granulomatosis With Polyangiitis ◽  
Hypertrophic Pachymeningitis

Hypertrophic pachymeningitis in a patient with ANCA negative granulomatosis with polyangiitis: A case report

2020 ◽  
Vol 27 (4) ◽  
pp. 291-297
Author(s):  
Jorge Huaringa-Marcelo ◽  
Rubén Kevin Arnold Tapia-Orihuela ◽  
David Loja-Oropeza
Keyword(s):  
Case Report ◽  
Granulomatosis With Polyangiitis ◽  
Hypertrophic Pachymeningitis

scholarly journals A Case of Hypertrophic Pachymeningitis Associated with Immunoglobulin-G4 and c-ANCA

2019 ◽  
Vol 11 (3) ◽  
pp. 290-294 ◽  
Author(s):  
Stephanie Wyrostek ◽  
Satabdi Chakrabarti ◽  
Kelly Baldwin ◽  
J. David Avila
Keyword(s):  
Case Report ◽  
Dura Mater ◽  
Granulomatosis With Polyangiitis ◽  
Inflammatory Diseases ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Hypertrophic Pachymeningitis ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Systemic Manifestations

Hypertrophic pachymeningitis (HP) is characterized by inflammation of the dura mater. It has been described in the setting of numerous systemic inflammatory diseases including immunoglobulin G4 (IgG4)-related disease as well as granulomatosis with polyangiitis (GPA). In this case report, we describe a 48-year-old man presenting with headache who was found to have HP and had systemic features of both GPA and IgG4-related disease as well as seropositivity for both cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) and IgG4. He was treated with prednisone and rituximab with improvement in his symptoms. Co-occurrence of IgG4 and ANCA against myeloperoxidase has been reported in other cases of HP. The overlap between IgG4 and ANCA has also been described in other systemic manifestations of the diseases. These reports suggest a clinical overlap between ANCA and IgG4-related disease, and the case presented herein suggests an overlap between GPA and IgG4-related disease.

scholarly journals AB0858 SUCCESSFUL TERM PREGNANCY IN A PATIENT WITH GRANULOMATOSIS WITH POLYANGIITIS AFTER UNDERGOING RITUXIMAB THERAPY - CASE REPORT

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1452.2-1453
Author(s):  
O. Sirenko ◽  
O. Kuryata ◽  
T. Lysunets ◽  
A. Legkobyt ◽  
H. Mostova
Keyword(s):  
Case Report ◽  
Granulomatosis With Polyangiitis ◽  
Disease Onset ◽  
Biological Agents ◽  
Term Pregnancy ◽  
Aseptic Necrosis ◽  
Azathioprine Therapy ◽  
Disease Remission ◽  
Obstetric Medicine ◽  
Patient Reported

Background:Granulomatosis with polyangiitis (GWP) is a relatively rare disease with the lack of experience in the management of pregnancy currently. Potentially negative factors of pregnancy prognosis are both disease-related and teratogenic effects of specific vasculitis therapy [1].Objectives:To describe a clinical case of Successful term pregnancy in a patient with Granulomatosis with polyangiitis after undergoing rituximab therapy.Methods:19 years-old woman was admitted to the rheumatology department of Clinical Regional Hospital After Mechnicov in 2013 with the debut of Granulomatosis with polyangiitis. Her disease course included recurrent rhinitis and sinusitis, Granulomatosis of the eye orbits. Positive ANCA titers were present in the disease onset. In the preceding 7 years she had been treated with corticosteroids, cyclophospan (discontinuated in 2017 because of lack of efficiency), than azathioprine. Aseptic necrosis of the both femoral head was estimated on fifth disease year. In 2018 azathioprine therapy had been discontinued owing to the disease progression and biological agents were prescribed – rituximab with positive effect. The disease remission was achived by rituximab therapy, the patient was warned about the need for contraception. The last dose of rituximab was introduced in February 2020. However, in March 2020, the patient reported pregnancy and therapy was discontinued. At the onset of pregnancy she was treated with 6 mg oral methylprednisolone. Daily and this dose was stable till all pregnancy period. Fetal growth assessment, congenital abnormalities screening test, and laboratory tests for gestational diabetes and preeclampsia were unremarkable during all gestational trimesters. The ANCA titers remained negative and renal function was normal and there was no flare during all pregnancy period.Results:At 38 weeks’ gestation a spontataneous labor started without induction. A 3270-g healthy boy delivered with APGAR score of 9 at 1 minute and 5 minutes. Postpartum the disease remained in remission, and the patient was maintained on corticosteroids. The infant was healthy, with normal development.Conclusion:Thus, the use of biological agents therapy in patients with GWP shows possible ways to safe reproductive potential with disease remission achievement.References:[1]Daher A, Sauvetre G, Girszyn N, Verspyck E, Levesque H, Le Besnerais M. Granulomatosis with polyangiitis and pregnancy: A case report and review of the literature. Obstetric Medicine. 2020;13(2):76-82. doi:10.1177/1753495X18822581Disclosure of Interests:None declared

scholarly journals A Case Report of Wegener's Granulomatosis with Hypertrophic Pachymeningitis.

2002 ◽  
Vol 95 (11) ◽  
pp. 1101-1106 ◽  
Author(s):  
Akihiro KATADA ◽  
Kan KISHIBE ◽  
Hayabusa NOZAWA ◽  
Seigo UEDA ◽  
Masanobu IMADA ◽  
...  
Keyword(s):  
Case Report ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Hypertrophic Pachymeningitis

Idiopathic hypertrophic pachymeningitis, a case report

2021 ◽  
Vol 429 ◽  
pp. 119342
Author(s):  
Daniel Rebolledo García ◽  
José Antonio Serna Higareda ◽  
David Eduardo Prestegui Muñoz ◽  
Rosa Xel Ha Dominguez Vega
Keyword(s):  
Case Report ◽  
Hypertrophic Pachymeningitis
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