Biomarkers in Childhood-Onset Systemic Lupus Erythematosus

2022 ◽  
Vol 48 (1) ◽  
pp. 271-285
Author(s):  
Ellen M. Cody ◽  
Hermine I. Brunner
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Vitor Cavalcanti Trindade ◽  
Magda Carneiro-Sampaio ◽  
Eloisa Bonfa ◽  
Clovis Artur Silva
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Social phobia in childhood-onset systemic lupus erythematosus

2014 ◽  
Vol 12 (Suppl 1) ◽  
pp. P333
Author(s):  
Catia Nascimento ◽  
Renata Barbosa ◽  
Luciana Oliveira ◽  
Karina Peliçari ◽  
Nailu Sinicato ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Social Phobia ◽  
Lupus Erythematosus ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Depression and medication nonadherence in childhood-onset systemic lupus erythematosus

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1532-1541 ◽  
Author(s):  
A M Davis ◽  
T B Graham ◽  
Y Zhu ◽  
M L McPheeters
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Medication Adherence ◽  
Lupus Erythematosus ◽  
Depression Symptoms ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Medication Nonadherence ◽  
Disease Characteristics ◽  
Prevalence Of Depression ◽  
Onset Systemic Lupus Erythematosus

Objectives Depression and medication nonadherence are important in managing chronic diseases, but little is known about these factors in childhood-onset systemic lupus erythematosus (cSLE). The objectives of this cross-sectional study were to estimate prevalence of depression and medication nonadherence, describe demographic and disease characteristics associated with depression and medication nonadherence, and evaluate the association between depression and medication nonadherence in cSLE patients. Methods Patients with cSLE ( n = 51) completed validated screening questionnaires to identify depression and medication nonadherence, Patient Health Questionnaire-9 and Medication Adherence Self-Report Inventory, respectively. Demographic and disease characteristics were obtained via chart abstraction, and compared between groups of depression or medication nonadherence status. A multivariable linear regression model adjusting for propensity scores was conducted to evaluate the association between depression and medication nonadherence. Results The prevalence of a positive depression screen was 58.8%, and seven patients reported suicidal ideation (13.7%). The prevalence of self-reported medication nonadherence was 19.7%. No statistically significant differences for demographic and disease characteristics were found between patients with a positive vs. negative depression screen. Patients reporting medication nonadherence were more likely to have longer disease duration (4.8 vs. 2.6 years, p = 0.035). As the severity of depression symptoms increased, the degree of medication nonadherence also increased (beta = –1.89; p = 0.011). Conclusions The prevalence of depression and medication nonadherence is high in cSLE, and these factors have a direct relationship. Interventions that better recognize and treat depression and increase rates of medication adherence are needed to improve outcomes in cSLE.

scholarly journals Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
M. Javad Wahadat ◽  
Iris L. A. Bodewes ◽  
Naomi I. Maria ◽  
Cornelia G. van Helden-Meeuwsen ◽  
Annette van Dijk-Hummelman ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Type I ◽  
Type I Ifn ◽  
Childhood Onset ◽  
Systemic Lupus ◽  
Dna And Rna ◽  
Onset Systemic Lupus Erythematosus
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