scholarly journals Major differences in the levels of redox status and antioxidant defence markers in the erythrocytes of pre- and full-term neonates with intrauterine growth restriction

2015 ◽  
Vol 53 ◽  
pp. 10-14 ◽  
Author(s):  
Ágnes Ferencz ◽  
Hajnalka Orvos ◽  
Edit Hermesz
Keyword(s):  
Intrauterine Growth Restriction ◽  
Redox Status ◽  
Full Term ◽  
Growth Restriction ◽  
Antioxidant Defence ◽  
Term Neonates ◽  
Intrauterine Growth

scholarly journals Transcriptome Analysis of Intestinal Dysfunction in Newborn Piglets with Intrauterine Growth Restriction and Improve their Performance by Dimethylglycine Sodium Salt Supplementation after Weaning

2021 ◽  
Author(s):  
Kaiwen Bai ◽  
Luyi Jiang ◽  
Qiming Li ◽  
Jingfei Zhang ◽  
Lili Zhang ◽  
...  
Keyword(s):  
Sodium Salt ◽  
Mitochondrial Function ◽  
Intrauterine Growth Restriction ◽  
Digestive Enzyme ◽  
Redox Status ◽  
Growth Restriction ◽  
Rna Seq ◽  
Weaned Piglets ◽  
Intrauterine Growth ◽  
Newborn Piglets

Abstract Background Few studies are available on the mechanism of intestinal dysfunction in newborn piglets with intrauterine growth restriction (IUGR). This work aimed to study the mechanism of jejunum dysfunction in IUGR newborn piglets through RNA-seq and improve their performance by dimethylglycine sodium salt (DMG-Na) supplementation after weaning. Methods In total, 13 normal birth weight (NBW) newborn piglets and 23 IUGR newborn piglets were obtained. Among them, 3 NBW and 3 IUGR newborn piglets were selected and stunned by electric shock after birth without suckling and collected the jejunum samples for RNA-sEq. After weaning at 21 days, they were randomly assigned to 3 groups (n = 10): NBW weaned piglets fed with common basal diets (N); IUGR weaned piglets fed with common basal diets (I); IUGR weaned piglets fed with common basal diets plus 0.1% DMG-Na (ID). All piglets are slaughtered at 49 days of age to collect serum and jejunum samples. Results The hub genes, including ATP8, C11orf86, CDKN1C, DDX58. HPX, INHBB, LECT2, ND1, NFIX, PRDM5, PSD3, SCD, and ZNF770, were found from the data analyzed by RNA-seq and WGCNA. Interestingly, we found ATP8 was the most significantly changed gene, which was crucial in maintaining mitochondrial function. After weaning, the growth performance of ID group was improved (P < 0.05) compared to that in I group. Jejunum histological morphology and its sub-organelle ultrastructure, serum immunoglobulin, jejunum sIgA level, and jejunum digestive enzyme activity were improved (P < 0.05) in ID group compared to those in I group. The redox status of serum, jejunum and its mitochondrial, as well as jejunum redox status-related and mitochondrial function-related gene expression level and protein content were improved (P < 0.05) in ID group in comparison to those in I group. Conclusion The activity of the SIRT1/PGC1α pathway was inhibited in the IUGR weaned piglets, which in turn leads to damage to their redox status and jejunum structure and function, and finally lowers their performance. The IUGR weaned piglets activate the SIRT1/PGC1α pathway by taking in the antioxidant substance like DMG-Na, thereby improving their unfavorable body state.

scholarly journals Clara cell protein in full-term pregnancies: The influence of intrauterine growth restriction

2010 ◽  
Vol 45 (12) ◽  
pp. 1186-1191 ◽  
Author(s):  
Despina D. Briana ◽  
Dimitrios Gourgiotis ◽  
Maria Boutsikou ◽  
Stavroula Baka ◽  
Antonios Marmarinos ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Full Term ◽  
Growth Restriction ◽  
Clara Cell ◽  
Cell Protein ◽  
Clara Cell Protein ◽  
Intrauterine Growth

scholarly journals 382 The Effect of Intrauterine Growth Restriction on Circulating Concentrations of Bone Collagen Markers in Full-Term Pregnancies

2010 ◽  
Vol 68 ◽  
pp. 197-197
Author(s):  
D D Briana ◽  
M Boutsikou ◽  
D Gourgiotis ◽  
A Karali ◽  
A Marmarinos ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Full Term ◽  
Growth Restriction ◽  
Bone Collagen ◽  
Intrauterine Growth ◽  
Collagen Markers

scholarly journals Surgical management of cellular congenital mesoblastic nephroma in a neonate: a case report and review of literature

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Ali Ihab ◽  
Al Otaibi Abdullah ◽  
Abduldaem Abdullah ◽  
Alonazi Mohammad ◽  
Nojoom Maha
Keyword(s):  
Blood Pressure ◽  
Multidisciplinary Team ◽  
Intrauterine Growth Restriction ◽  
Abdominal Mass ◽  
Full Term ◽  
Growth Restriction ◽  
Mesoblastic Nephroma ◽  
Intrauterine Growth ◽  
Congenital Mesoblastic Nephroma ◽  
The Right

Abstract Background Congenital mesoblastic nephroma (CMN) is the most common type of renal stromal tumor in neonates. It is classified into cellular, classical, and mixed types. The multidisciplinary management approach is the mainstay of management. We are reporting a case of neonatal congenital mesoblastic nephroma in a full-term boy with intrauterine growth restriction and hypertension managed effectively in our institution. Case presentation A full-term boy with intrauterine growth restriction (IUGR) with a birth weight of 2.3 kg, referred at birth with an abdominal mass. His antenatal scan at 35 weeks showed a cystic abdominal mass. On delivery, a huge visible abdominal mass of cystic consistency and smooth surface was noticed at the right side of the abdomen. blood pressure was 98/75 mmHg. It was responsive to hydralazine. Aldosterone and renin were significantly elevated at more than 100 and 500 ng/dl, respectively. Serum neurone-specific enolase (NSE) was 35 ng/ml while alfa feto protein was (AFP) 50,000 kIU/L. An abdominal ultrasound scan revealed an ill-defined large heterogeneous mass of 6.09 × 6.5 × 5.77 cm that arises from the right kidney. A computed tomography scan confirmed a right kidney mass with peripheral claw sign of the normal right renal tissue. It was crossing the midline and causing a mass effect on the adjacent structures. The right renal artery and vein were compressed and shifted posteriorly and inferomedially. Right radical nephrectomy was performed via a right lower transverse incision. The tumor was completely excised with a tumor weight of 270 g and a size of 10.5 × 8 × 5.5 cm. Histopathological diagnosis was mesoblastic nephroma of a cellular type which was confirmed by immunohistochemistry. Post-operatively, the blood pressure has significantly reduced and antihypertensive medications were eventually weaned off. The multidisciplinary team decided to preserve chemotherapy only in case of recurrence. At 3 months follow-up, no features of recurrence were noticed based on surveillance ultrasonography. Conclusion Mesoblastic nephroma should be considered in any newborn with renal mass. The multidisciplinary team approach with aggressive management of hypertension, detailed radiological investigation, and complete tumor resection is fundamental for obtaining an excellent outcome for such entities.

scholarly journals 384 Evidence That Intrauterine Growth Restriction May Enhance Type Iii Collagen Synthesis in Full-Term Pregnancies

2010 ◽  
Vol 68 ◽  
pp. 198-198
Author(s):  
D D Briana ◽  
D Gourgiotis ◽  
M Boutsikou ◽  
A Kakaroukas ◽  
L Stamati ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Collagen Synthesis ◽  
Full Term ◽  
Growth Restriction ◽  
Type Iii Collagen ◽  
Intrauterine Growth ◽  
Type Iii
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