Designer self-assembling peptide nanofiber scaffolds for 3D tissue cell cultures

2005 ◽  
Vol 15 (5) ◽  
pp. 413-420 ◽  
Author(s):  
Shuguang Zhang ◽  
Fabrizio Gelain ◽  
Xiaojun Zhao
Biomaterials ◽  
2013 ◽  
Vol 34 (21) ◽  
pp. 4902-4913 ◽  
Author(s):  
Zhongli Luo ◽  
Yuanyuan Yue ◽  
Yanfang Zhang ◽  
Xiao Yuan ◽  
Jianping Gong ◽  
...  

2004 ◽  
Vol 820 ◽  
Author(s):  
Xiaojun Zhao ◽  
Jessica Dai ◽  
Shuguang Zhang

AbstractWe designed and fabricated a class of self-assembling peptides into nanofiber scaffolds. KLDL-12 has been shown to be a permissible nanofiber scaffold for chondrocytes in cartilage 3-D cell cultures. However, the biochemical, structural, and biophysical properties of KLDL- 12 remain unclear. We show that KLDL-12 peptides form stable β-sheet structures at different pH values and that KLDL-12 and RIDI-12 self-assemble into nanofibers. The nanofiber length, though, is sensitive to pH changes. These results not only suggest the importance of electrostatic attraction or repulsion affecting the fiber lengths but also provide us with useful information for rational design and fabrication of peptide scaffolds.


2004 ◽  
Vol 823 ◽  
Author(s):  
Xiaojun Zhao ◽  
Jessica Dai ◽  
Shuguang Zhang

AbstractWe designed and fabricated a class of self-assembling peptides into nanofiber scaffolds. KLDL-12 has been shown to be a permissible nanofiber scaffold for chondrocytes in cartilage 3-D cell cultures. However, the biochemical, structural, and biophysical properties of KLDL-12 remain unclear. We show that KLDL-12 peptides form stable β-sheet structures at different pH values and that KLDL-12 and RIDI-12 self-assemble into nanofibers. The nanofiber length, though, is sensitive to pH changes. These results not only suggest the importance of electrostatic attraction or repulsion affecting the fiber lengths but also provide us with useful information for rational design and fabrication of peptide scaffolds.


2016 ◽  
Vol 2 (6) ◽  
pp. 1030-1038 ◽  
Author(s):  
Nicola L. Francis ◽  
Neal K. Bennett ◽  
Apoorva Halikere ◽  
Zhiping P. Pang ◽  
Prabhas V. Moghe

1961 ◽  
Vol 82 (4) ◽  
pp. 542-547 ◽  
Author(s):  
Jack S. Bailey ◽  
Harold W. Clark ◽  
William R. Felts ◽  
Richard C. Fowler ◽  
Thomas McP. Brown

1968 ◽  
Vol 21 (4) ◽  
pp. 259-273 ◽  
Author(s):  
HIDEMASA OGAWA ◽  
AKIKO NAKAMURA ◽  
RINTARO NAKAYA

Nature ◽  
1961 ◽  
Vol 191 (4784) ◽  
pp. 190-191 ◽  
Author(s):  
W. F. MALIZIA ◽  
M. F. BARILE ◽  
D. B. RIGGS
Keyword(s):  

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