Comment on: 3 year follow-up comparing metabolic surgery versus medical weight management in patients with type 2 diabetes and BMI 30–35; the role of sRAGE biomarker as predictor of satisfactory outcomes

2016 ◽  
Vol 12 (7) ◽  
pp. 1342
Author(s):  
Gordon G. Wisbach
Keyword(s):  
Type 2 Diabetes ◽  
Weight Management ◽  
Metabolic Surgery ◽  
Medical Weight Management

scholarly journals Profibrotic circulating proteins and risk of early progressive renal decline in Type 2 Diabetes patients with and without albuminuria

2020 ◽  
Author(s):  
Katsuhito Ihara ◽  
Jan Skupien ◽  
Hiroki Kobayashi ◽  
Zaipul I. Md Dom ◽  
Jonathan M. Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Core Domain ◽  
Fibrotic Process ◽  
Baseline Levels ◽  
Design And Methods ◽  
Circulating Levels ◽  
Index Combination

<b>OBJECTIVE</b>: The role of fibrosis in early progressive renal decline in type 2 diabetes is unknown. Circulating WFDC2 (WAP four-disulfide core domain protein 2) and MMP-7 (Matrilysin) are postulated to be biomarkers of renal fibrosis. This study examined an association of circulating levels of these proteins with early progressive renal decline. <p><b>RESEARCH DESIGN AND METHODS</b>: Individuals with type 2 diabetes enrolled in the Joslin Kidney Study with eGFR ≥60 ml/min/1.73m<sup>2</sup> were followed for 6-12 years to ascertain fast early progressive renal decline defined as eGFR loss ≥5 ml/min/1.73m<sup>2</sup>/year. </p> <p><b>RESULTS</b>: A total of 1,181 individuals were studied: 681 without and 500 with albuminuria. Median eGFR and ACR at baseline were 97 ml/min/1.73m<sup>2</sup> and 24 mg/g, respectively. During follow-up, 152 individuals experienced fast early progressive renal decline: 6.9% in those with normoalbuminuria and 21% with albuminuria. In both subgroups risk of renal decline increased with increasing baseline levels of WFDC2 (p <0.0001) and MMP-7 (p <0.0001). After adjustment for relevant clinical characteristics and known biomarkers, an increase by one quartile in the Fibrosis Index (combination of levels of WFDC2 and MMP-7) was associated with higher risk of renal decline (OR 1.63; 95% CI 1.30-2.04). The association was similar and statistically significant among patients with and without albuminuria. </p> <p><b>CONCLUSIONS: </b>Elevation of circulating profibrotic proteins is associated with the development of early progressive renal decline in type 2 diabetes. This association is independent from albuminuria status and points to the importance of the fibrotic process in development of early renal decline. </p>

scholarly journals Role of vitamin D in energy and bone metabolism in postmenopausal women with type 2 diabetes mellitus: A 6-month follow-up evaluation

2017 ◽  
Vol 9 (1) ◽  
pp. 211-222 ◽  
Author(s):  
Makiko Ogata ◽  
Naoko Iwasaki ◽  
Risa Ide ◽  
Miho Takizawa ◽  
Mizuho Tanaka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Bone Metabolism ◽  
Postmenopausal Women

The Role of Gastrointestinal Metabolic Surgery in the Management of Type 2 Diabetes

2009 ◽  
Vol 05 (01) ◽  
pp. 69
Author(s):  
Angelo Cioppa ◽  
Luigi Salemme ◽  
Vittorio Ambrosini ◽  
Giovanni Sorropago ◽  
Eugenio Stabile ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Surgery ◽  
Gastrointestinal Metabolic Surgery

scholarly journals The role of metabolic surgery in the treatment of patients with type 2 diabetes mellitus

2019 ◽  
Vol 15 (3) ◽  
pp. 236-245
Author(s):  
M.D. Tronko ◽  
V.L. Orlenko ◽  
S.I. Savoliuk ◽  
M.Yu. Krestianov ◽  
O.V. Dobrovynska ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Metabolic Surgery

Role of probiotics for the treatment of peri-implant mucositis in patients with and without type-2 diabetes mellitus

2020 ◽  
Author(s):  
Fawaz Alqahtani ◽  
Maha Alshaikh ◽  
Abid Mehmood ◽  
Nasser Alqhtani ◽  
Fahad Alkhtani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Patients ◽  
Treatment Procedure ◽  
Inflammatory Parameters ◽  
Probing Depth ◽  
Crestal Bone Loss ◽  
Group 2

The hypothesis was that probiotic therapy (PT) does not offer additional benefits to mechanical debridement (MD) for treatment of diabetic subjects with peri-implant mucositis (PM). This study compared the influence of PT as an adjunct to MD for the treatment of PM in type2 diabetic and non-diabetic patients over a 12-month follow-up period. Patients with and without type-2 diabetes were encompassed. Based upon treatment-procedure, PM patients were categorized into 2 groups: (a) Non-surgical + PT; and (b) Group-2: Non-surgical MD alone. Demographics and education statuses were recorded. Gingival (GI) and plaque (PI) indices, crestal bone loss (CBL) and probing depth (PD were measured at baseline and after 6- and 12-months. Significant differences were detected with P&lt;0.01. The HbA1c was significantly higher in diabetic patients at all time durations than patients without type-2 diabetes (P&lt;0.001). Baseline GI, PI, PD and CBL) were comparable in all groups. In patients with type-2-diabetes, there was no difference in PI, GI, PD and CBL at 6- and 12-months’ follow-up. In patients without type-2 diabetes, there was a significant reduction in PI (P&lt;0.01), GI (P&lt;0.01), and PD (P&lt;0.01) at 6-months and 1-year follow-up than their values at baseline. In patients without type-2 diabetes, MD with or without adjunct PT reduces soft tissue inflammatory parameters in patients with PM.

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