Abstract
Background: The aim of this study was to determine the risk factors and develop a nomogram for blood transfusions after posterior lumbar spinal fusion (PSL).Methods: We conducted a retrospective, single-center study based on 885 patients receiving lumbar PSL, and data was obtained from May 2015 to September 2019. Multivariable logistic regression analysis was conducted to identified risk factors for blood transfusion, and a nomogram was constructed to individually evaluate the risk of blood transfusion. Discrimination, calibration, and clinical usefulness were validated by the receiver operating characteristics (ROC), C-index, calibration plot, and decision curve analysis, respectively. Bootstrapping validation was performed to assess the performance of the model.Results: Of 885 patients, 885 were enrolled in the final study population and 289 receive blood transfusion. Statistical analyses showed the low preoperative hemoglobin (Hb), longer time to surgery, operative time, levels of fusion>1, longer surgery duration, and higher total intraoperative blood loss (IBL) were the risk factors for transfusion. The C-index was 0.898 (95% CI: 0.847–0.949) in this dataset and 0.895 in bootstrapping validation, respectively. Calibration curve showed satisfied discrimination and calibration of the nomogram. Decision curve analysis (DCA) shown that the nomogram was clinical utility.Conclusions: In summary, we investigated the relationship between the blood transfusion requirement and predictors: levels of fusion, operative time, time to surgery, total intraoperative EBL, and preoperative Hb level. Our nomogram with a robust performance in the assessment of risk of transfusion, which can contribute clinicians making clinical decision. However, external validation is still needed in the further.
Risk factors affected the facet joint violation during minimal invasive spinal surgery
