scholarly journals Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction

2017 ◽  
Vol 8 (3) ◽  
pp. 509-518 ◽  
Author(s):  
Morito Takano ◽  
Soya Kawabata ◽  
Shinsuke Shibata ◽  
Akimasa Yasuda ◽  
Satoshi Nori ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Aged Mice ◽  
Cord Injury

scholarly journals Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis

2018 ◽  
Vol 51 (3) ◽  
pp. 180 ◽  
Author(s):  
Hojjat-Allah Abbaszadeh ◽  
Somayeh Niknazar ◽  
Shahram Darabi ◽  
Navid Ahmady Roozbahany ◽  
Ali Noori-Zadeh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Functional Recovery ◽  
Meta Analysis ◽  
Cord Injury

Stem Cell Transplantation: A Promising Therapy for Spinal Cord Injury

2020 ◽  
Vol 15 (4) ◽  
pp. 321-331 ◽  
Author(s):  
Zhe Gong ◽  
Kaishun Xia ◽  
Ankai Xu ◽  
Chao Yu ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Potential ◽  
Embryonic Stem ◽  
Current Status ◽  
Cord Injury

Spinal Cord Injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced Pluripotent Stem Cells (iPSCs), Embryonic Stem Cells (ESCs), Mesenchymal Stem Cells (MSCs) and Neural Progenitor Cells (NPCs) /Neural Stem Cells (NSCs) have therapeutic potential for SCI. However, the efficacy and safety of these stem cellbased therapy for SCI remain controversial. In this review, we introduce the pathogenesis of SCI, summarize the current status of the application of these stem cells in SCI repair, and discuss possible mechanisms responsible for functional recovery of SCI after stem cell transplantation. Finally, we highlight several areas for further exploitation of stem cells as a promising regenerative therapy of SCI.

scholarly journals A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury

2018 ◽  
Vol 22 (6) ◽  
pp. 941-950.e6 ◽  
Author(s):  
Erik Curtis ◽  
Joel R. Martin ◽  
Brandon Gabel ◽  
Nikki Sidhu ◽  
Teresa K. Rzesiewicz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Phase I ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Phase I Study ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury

2004 ◽  
Vol 12 (3-4) ◽  
pp. 343-358 ◽  
Author(s):  
Terence M. Myckatyn ◽  
Susan E. Mackinnon ◽  
John W. McDonald
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Cord Injury
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