Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro

Steroids ◽  
2011 ◽  
Vol 76 (1-2) ◽  
pp. 156-162 ◽  
Author(s):  
Renáta Minorics ◽  
Thomas Szekeres ◽  
Georg Krupitza ◽  
Philipp Saiko ◽  
Benedikt Giessrigl ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Human Leukemia ◽  
Antiproliferative Effects ◽  
Human Leukemia Cells

In Vitro Anti-proliferative Effects on NB4 Human Leukemia Cells and Physicochemical Screening of Pleurotus sp. (Higher Basidiomycetes) Mycelia from Cuba

2014 ◽  
Vol 16 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Humberto J. Morris ◽  
Edgar Hernandez ◽  
Gabriel Llaurado ◽  
Maria Cristina Tejedor ◽  
Pilar Sancho ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells

Antiproliferative effects of galectin-1 from Rana catesbeiana eggs on human leukemia cells and its binding proteins in human cells

2011 ◽  
Vol 47 (10) ◽  
pp. 728-734
Author(s):  
Hidetaro Yasumitsu ◽  
Keiichi Mochida ◽  
Chie Yasuda ◽  
Masaharu Isobe ◽  
Sarkar M. A. Kawsar ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Rana Catesbeiana ◽  
Human Cells ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Antiproliferative Effects ◽  
Human Leukemia Cells

scholarly journals In Vitro and In Vivo Apoptosis-Inducing Antileukemic Effects of Mucuna macrocarpa Stem Extract on HL-60 Human Leukemia Cells

2010 ◽  
Vol 9 (3) ◽  
pp. 298-308 ◽  
Author(s):  
Kuan-Hung Lu ◽  
Yuh-Fang Chang ◽  
Pen-Hui Yin ◽  
Ting-Ting Chen ◽  
Yu-Ling Ho ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Human Leukemia ◽  
Human Leukemia Cells ◽  
Stem Extract

scholarly journals Non-toxic polymer nanovectors for improved delivery of dexamethasone

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Benjamin C. Ede ◽  
Paraskevi Diamanti ◽  
David S. Williams ◽  
Allison Blair
Keyword(s):  
Drug Exposure ◽  
Free Drug ◽  
Leukemia Cells ◽  
Human Leukemia ◽  
Front Line ◽  
Broad Distribution ◽  
Human Leukemia Cells ◽  
Line Drug

AbstractDexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing absolute dose may improve efficacy. Non-toxic, fully biodegradable Dex loaded nanovectors (NV) were formulated, via simple direct hydration within 10 min, as a vehicle to extend exposure and distribution in vivo. Dex-NV were just as effective as the free drug against primary human leukemia cells in vitro and in vivo. Importantly, high levels of DMSO solvent were not required in the NV formulations. Broad distribution of NV was seen rapidly following inoculation into mice. NV accumulated in major organs, including bone marrow and brain, known sanctuary sites for ALL. The study describes a non-toxic, more easily scalable system for improving Dex solubility for use in cancer and can be applied to other medical conditions associated with inflammation.

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