Investigation of photophysical, photochemical and bovine serum albumin binding properties of novel water-soluble zwitterionic zinc phthalocyanine complexes

Bovine serum albumin complexes with water-soluble cationic porphyrins, Cu - and Co-meso-tetra(4- N -hydroxyethylpyridyl)porphyrins ( CuT4OEPyP , CoT4OEPyP ), and their 3- N -analogs, meso-tetra(3- N -hydroxyethylpyridyl)porphyrins ( CuT3OEPyP , CoT3OEPyP ), have been investigated. The porphyrin-bovine serum albumin binding was monitored by the absorption in the visible region at 400-460 nm. The stoichiometry of binding and the binding constants of the porphyrins to bovine serum albumin were determined using binding isotherms and Scatchard plots. The K b values obtained for these porphyrin- bovine serum albumin complexes are 1.7 × 105 M −1, 3.2 × 105 M −1, 1.4 × 105 M −1 and 3 × 105 M −1 respectively. Binding constants are sensitive to pH and ionic strength of the solution.

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A Fluorescence Analysis of ANS Bound to Bovine Serum Albumin: Binding Properties Revisited by Using Energy Transfer

Journal of Fluorescence ◽

10.1007/s10895-007-0294-x ◽

2007 ◽

Vol 18 (2) ◽

pp. 519-526 ◽

Cited By ~ 74

Author(s):

Denisio M. Togashi ◽

Alan G. Ryder

Keyword(s):

Energy Transfer ◽

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Fluorescence Analysis ◽

Albumin Binding ◽

Binding Properties ◽

Bovine Serum Albumin Binding

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Water soluble peripheral and non-peripheral tetrasubstituted zinc phthalocyanines: Synthesis, photochemistry and bovine serum albumin binding behavior

Journal of Luminescence ◽

10.1016/j.jlumin.2014.04.030 ◽

2014 ◽

Vol 154 ◽

pp. 274-284 ◽

Cited By ~ 22

Author(s):

Volkan Çakır ◽

Dilek Çakır ◽

Mehmet Pişkin ◽

Mahmut Durmuş ◽

Zekeriya Bıyıklıoğlu

Keyword(s):

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Water Soluble ◽

Albumin Binding ◽

Binding Behavior ◽

Zinc Phthalocyanines ◽

Bovine Serum Albumin Binding

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Photophysical, photochemical and bovine serum albumin binding studies on water-soluble gallium(III) phthalocyanine derivatives

Journal of Porphyrins and Phthalocyanines ◽

10.1142/s1088424607000746 ◽

2007 ◽

Vol 11 (09) ◽

pp. 635-644 ◽

Cited By ~ 18

Author(s):

Abimbola Ogunsipe ◽

Tebello Nyokong ◽

Mahmut Durmuş

Keyword(s):

Bovine Serum Albumin ◽

Serum Albumin ◽

Bovine Serum ◽

Binding Constants ◽

Water Soluble ◽

Albumin Binding ◽

Binding Studies ◽

Amphiphilic Compounds ◽

Yield Values ◽

Bovine Serum Albumin Binding

Spectral, photophysical, photochemical and bovine serum albumin binding studies on some gallium(III) derivatives - {1,(4)-(tetrapyridyloxyphthalocyaninato)gallium(III), (α GaPc ); 2,(3)-(tetrapyridyloxyphthalocyaninato)gallium(III), (β GaPc ); and their quaternized derivatives: Q α GaPc and Q β GaPc )} are hereby presented. β-Substituted complexes are more fluorescent, but show lower tendencies to undergo intersystem crossing than the α-substituted, as judged by their fluorescence and triplet quantum yield values. The quaternized derivatives ( QGaPc ) are water-soluble and non-aggregated, which makes them potential photosensitizers of choice for photodynamic therapy applications; these amphiphilic compounds also bind strongly to bovine serum albumin in 1:1 stoichiometries, and with binding constants ( Kb) in the order of 106M−1.

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