Cascade assembly of the benz[a]anthraquinone ring system common to the angucycline antibiotics

ABSTRACTThis paper models maximum entropy configurations of idealized gravitational ring systems. Such configurations are of interest because systems generally evolve toward an ultimate state of maximum randomness. For simplicity, attention is confined to ultimate states for which interparticle interactions are no longer of first order importance. The planets, in their orbits about the sun, are one example of such a ring system. The extent to which the present approximation yields insight into ring systems such as Saturn's is explored briefly.

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Cyclic nucleotide phosphodiesterase type 4 inhibitors: evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(03)00149-1 ◽

2003 ◽

Author(s):

P Raboisson

Keyword(s):

Cyclic Nucleotide ◽

Ring System ◽

Cyclic Nucleotide Phosphodiesterase ◽

Triazine Ring ◽

Phosphodiesterase Type

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Effectiveness of Brushing Associated with Oral Irrigation in Maintenance of Peri-Implant Tissues and Overdentures: Clinical Parameters and Patient Satisfaction.

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00092 ◽

2020 ◽

Author(s):

Marcela Moreira Salles ◽

Viviane de Cássia Oliveira ◽

Ana Paula Macedo ◽

Claudia Helena Silva-Lovato ◽

Helena de Freitas Oliveira Paranhos

Keyword(s):

Patient Satisfaction ◽

Analogue Scale ◽

Ring System ◽

Complete Dentures ◽

Gingival Index ◽

Prosthetic Rehabilitation ◽

Mean Values ◽

Probing Depth ◽

Significant Difference ◽

High Level

Implant-supported prostheses hygiene and peri-implant tissues health are considered to be predictive factors for successful prosthetic rehabilitation. Therefore, the purpose of this study was to evaluate the effectiveness of brushing associated with oral irrigation measured as biofilm-removing capacity, maintenance of healthy oral tissues, and patient satisfaction. A randomized, crossover clinical trial was conducted with 38 patients who wore conventional maxillary complete dentures and mandibular overdentures retained by the O-ring system. The patients were instructed to use the following hygiene methods for 14 days: mechanical brushing [MB (brush and dentifrice - Control)]; and MB with oral irrigation [WP (Waterpik - Experimental)]. Biofilm-removing capacity and maintenance of healthy oral tissues were evaluated by the Modified Plaque Index (PI), Gingival Index (GI), Probing Depth (PD), and Bleeding on Probing Index (BP) recorded at baseline and after each method. In parallel, patients answered a specific questionnaire using a Visual Analogue Scale after each hygiene method. Data were analyzed by Friedman and Wilcoxon tests (α=0.05). The results showed significantly lower PI, GI, PD, and BP indices after application of the hygiene methods (P<0.001) than those observed at baseline. However, no significant difference was found between MB and WP. The satisfaction questionnaire responses to both methods showed high mean values for all questions, with no statistically significant difference found between the answers given after the use of MB and WP (P>0.05). The findings suggest that WP was effective in reducing PI, GI, PD, and BP indices and provided a high level of patient satisfaction.

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