Neuropeptide tyrosine and pain

2007 ◽  
Vol 28 (2) ◽  
pp. 93-102 ◽  
Author(s):  
Pablo Brumovsky ◽  
Tiejun S. Shi ◽  
Marc Landry ◽  
Marcelo J. Villar ◽  
Tomas Hökfelt



1986 ◽  
Vol 372 (2) ◽  
pp. 353-356 ◽  
Author(s):  
Hisatake Kondo ◽  
Hirofumi Kuramoto ◽  
Tsuneo Fujita




2007 ◽  
Vol 55 (1) ◽  
pp. 107-122 ◽  
Author(s):  
Barbara Jana ◽  
Anna Dzienis ◽  
Joanna Wojtkiewicz ◽  
Monika Kaczmarek ◽  
M. Majewski

Changes in both the morphology and the steroidogenic activity of porcine ovaries denervated surgically on day 12 of the oestrous cycle were studied. Neurectomy of the plexus and the superior ovarian nerves caused a dramatic reduction in the number (or even a disappearance) of dopamine-β-hydroxylase- and/or neuropeptide tyrosine-immunoreactive nerve terminals. On day 20 of the subsequent oestrous cycle, the number of small follicles increased (P < 0.01) and that of large follicles decreased (P < 0.05) in the denervated ovaries, as compared to the controls. Neurectomy led to a decrease in the level of progesterone (P 4 ; P < 0.001) and androstenedione (A 4 ; P < 0.01) in the fluid from small follicles, A 4 (P < 0.001) and testosterone (T; P < 0.05) in the fluid from medium-sized follicles, as well as in the content of all these steroids in the fluid from large-sized follicles (P < 0.001 for P 4 and P < 0.05 for A 4 and T). Denervation also caused a decrease in the content of A 4 (P < 0.01) and T (P < 0.001) in the wall of follicles. Neurectomy resulted in a significant increase in the immunoexpression of cholesterol side-chain cleavage cytochrome P450 in the follicles and a decrease of 3β-hydroxysteroid dehydrogenase. After denervation, plasma levels of LH, P 4 , A 4 , T, oestrone and oestradiol-17β were lower (P < 0.05–0.001) on the particular days of the study than in the control group. Our data revealed that the denervation of ovaries during the middle luteal phase of the oestrous cycle in gilts caused distinct changes in both the morphology and the steroidogenic activity of the organ, confirming an important role of the peripheral nervous system in the control of the gonad in this species.



Peptides ◽  
1989 ◽  
Vol 10 (3) ◽  
pp. 551-558 ◽  
Author(s):  
L. Francisco López ◽  
Arnaldo Pérez ◽  
Serge St-Pierre ◽  
J.Pablo Huidobro-Toro


Peptides ◽  
1985 ◽  
Vol 6 (6) ◽  
pp. 1237-1243 ◽  
Author(s):  
S. Gulbenkian ◽  
J. Wharton ◽  
G.W. Hacker ◽  
I.M. Varndell ◽  
S.R. Bloom ◽  
...  


1983 ◽  
Vol 7 (3) ◽  
pp. 305
Author(s):  
Ian M. Varndell ◽  
Julia M. Polak ◽  
Janet M. Allen ◽  
Giorgio Terenghi ◽  
Stephen R. Bloom




1993 ◽  
Vol 90 (2) ◽  
pp. 687-691 ◽  
Author(s):  
J. Wharton ◽  
L. Gordon ◽  
J. Byrne ◽  
H. Herzog ◽  
L. A. Selbie ◽  
...  


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