scholarly journals Targeting intracellular protein–protein interactions with macrocyclic peptides

2021 ◽  
Author(s):  
Marina Buyanova ◽  
Dehua Pei
Keyword(s):  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Intracellular Protein ◽  
Macrocyclic Peptides

scholarly journals Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

2021 ◽  
Author(s):  
Shuhui Lim ◽  
Nicolas Boyer ◽  
Nicole Boo ◽  
Chunhui Huang ◽  
Gireedhar Venkatachalam ◽  
...  
Keyword(s):  
Small Molecules ◽  
Protein Interactions ◽  
Therapeutic Targets ◽  
Protein Protein Interactions ◽  
Intracellular Protein ◽  
Macrocyclic Peptides

Macrocyclic peptides have the potential to address intracellular protein-protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons...

Assessing the cellular toxicity of peptide inhibitors of intracellular protein-protein interactions by microinjection

2021 ◽  
Vol 29 ◽  
pp. 115906
Author(s):  
Sanjeevini Babu Reddiar ◽  
Hareth Al-Wassiti ◽  
Colin W. Pouton ◽  
Cameron J. Nowell ◽  
Macgregor A. Matthews ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Peptide Inhibitors ◽  
Protein Protein Interactions ◽  
Intracellular Protein ◽  
Cellular Toxicity

Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein–Protein Interactions

2020 ◽  
Vol 142 (47) ◽  
pp. 19950-19955
Author(s):  
Stephen E. Miller ◽  
Kohei Tsuji ◽  
Rachel P.M. Abrams ◽  
Terrence R. Burke ◽  
Joel P. Schneider
Keyword(s):  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Intracellular Protein ◽  
Lytic Peptides

scholarly journals Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions

2017 ◽  
Vol 60 (21) ◽  
pp. 8982-8988 ◽  
Author(s):  
Dennis M. Krüger ◽  
Adrian Glas ◽  
David Bier ◽  
Nicole Pospiech ◽  
Kerstin Wallraven ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Macrocyclic Peptides

A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein-Protein Interactions by Epitope and Arginine Grafting

2016 ◽  
Vol 128 (36) ◽  
pp. 10770-10773 ◽  
Author(s):  
Daisuke Fujiwara ◽  
Hidekazu Kitada ◽  
Masahiro Oguri ◽  
Toshio Nishihara ◽  
Masataka Michigami ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Intracellular Protein ◽  
Molecular Scaffold ◽  
Helix Loop Helix

scholarly journals Important Considerations Related to Permeability of Peptides

2021 ◽  
Vol 75 (6) ◽  
pp. 522-524
Author(s):  
Thomas E. Vorherr
Keyword(s):  
Protein Interactions ◽  
Oral Bioavailability ◽  
Intracellular Delivery ◽  
Oral Route ◽  
Assay Development ◽  
Alternative Methods ◽  
Protein Protein Interactions ◽  
Intracellular Protein ◽  
To Come ◽  
Peptide Uptake

This review on intracellular delivery and oral bioavailability of peptides reflects a number of principal investigations at Novartis. Our studies were aimed at either understanding features enabling peptides to interfere with intracellular protein–protein interactions, or to achieve a more patient-friendly delivery by the oral route. In the light of these objectives, we have also spent some effort on assay development to come up with alternative methods for monitoring cellular peptide uptake. This summary of our insights is intended to help in the assessment and development of peptide therapeutics requiring membrane transition

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