Phylogenetic analysis of the ATP-binding cassette super-family: Implications for the development of multiple drug resistance phenotype

Toxicology ◽  
2009 ◽  
Vol 262 (1) ◽  
pp. 12-13
Author(s):  
Ciaran Fisher ◽  
Tanya Coleman ◽  
Nick Plant
Keyword(s):  
Drug Resistance ◽  
Phylogenetic Analysis ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Atp Binding ◽  
Resistance Phenotype ◽  
Atp Binding Cassette

Reversion of the multiple-drug resistance phenotype mediated by short interfering RNAs

2005 ◽  
Vol 54 (5) ◽  
pp. 1298-1305 ◽  
Author(s):  
E. B. Logashenko ◽  
A. V. Vladimirova ◽  
A. N. Zenkov ◽  
M. N. Repkova ◽  
A. G. Ven'yaminova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Resistance Phenotype

Specifically activated dendritic cells—Cell-based vaccine against lymphosarcoma exhibiting multiple drug resistance phenotype

2009 ◽  
Vol 428 (1) ◽  
pp. 252-256
Author(s):  
N. L. Mironova ◽  
E. E. Panzinskyi ◽  
N. A. Popova ◽  
V. P. Nikolin ◽  
M. A. Zenkova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dendritic Cells ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Resistance Phenotype

scholarly journals DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 ◽  
Vol 2 (8) ◽  
pp. 881-889 ◽  
Author(s):  
P G Debenham ◽  
N Kartner ◽  
L Siminovitch ◽  
J R Riordan ◽  
V Ling
Keyword(s):  
Drug Resistance ◽  
Plasma Membranes ◽  
Multiple Drug Resistance ◽  
Chinese Hamster ◽  
Surface Glycoprotein ◽  
Multiple Drug ◽  
Cell Surface Glycoprotein ◽  
Resistance Phenotype ◽  
P Glycoprotein ◽  
Wide Range

Colchicine-resistant Chinese hamster ovary (CHO) cell mutants whose resistance results from reduced drug permeability have been isolated previously in our laboratories. This reduced permeability affects a wide range of unrelated drugs, resulting in the mutants displaying a multiple drug resistance phenotype. A 170,000-dalton cell surface glycoprotein (P-glycoprotein) was identified, and its expression appears to correlate with the degree of resistance. In this study we were able to confer the multiple drug resistance phenotype on sensitive mouse L cells by DNA-mediated gene transfer of DNA obtained from the colchicine-resistant mutants. P-glycoprotein was detected in plasma membranes of these DNA transformants by staining with an antiserum raised against membranes of mutant CHO cells. These results are consistent with a causal relationship between P-glycoprotein expression and the multiple drug resistance phenotype.

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression

1982 ◽  
Vol 2 (8) ◽  
pp. 881-889
Author(s):  
P G Debenham ◽  
N Kartner ◽  
L Siminovitch ◽  
J R Riordan ◽  
V Ling
Keyword(s):  
Drug Resistance ◽  
Plasma Membranes ◽  
Multiple Drug Resistance ◽  
Chinese Hamster ◽  
Surface Glycoprotein ◽  
Multiple Drug ◽  
Cell Surface Glycoprotein ◽  
Resistance Phenotype ◽  
P Glycoprotein ◽  
Wide Range

Colchicine-resistant Chinese hamster ovary (CHO) cell mutants whose resistance results from reduced drug permeability have been isolated previously in our laboratories. This reduced permeability affects a wide range of unrelated drugs, resulting in the mutants displaying a multiple drug resistance phenotype. A 170,000-dalton cell surface glycoprotein (P-glycoprotein) was identified, and its expression appears to correlate with the degree of resistance. In this study we were able to confer the multiple drug resistance phenotype on sensitive mouse L cells by DNA-mediated gene transfer of DNA obtained from the colchicine-resistant mutants. P-glycoprotein was detected in plasma membranes of these DNA transformants by staining with an antiserum raised against membranes of mutant CHO cells. These results are consistent with a causal relationship between P-glycoprotein expression and the multiple drug resistance phenotype.

Analysis of second-site mutations that suppress the multiple drug resistance phenotype of the yeast PDR1-7 allele

Gene ◽  
1995 ◽  
Vol 167 (1-2) ◽  
pp. 151-155 ◽  
Author(s):  
Thomas M. McGuire ◽  
Elvira Carvajal ◽  
David Katzmann ◽  
Marisa Wagner ◽  
W.Scott Moye-Rowley ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Resistance Phenotype
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