MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells

2017 ◽  
Vol 278 ◽  
pp. 38-47 ◽  
Author(s):  
Chengzhi Chen ◽  
Xuejun Jiang ◽  
Shiyan Gu ◽  
Zunzhen Zhang
Keyword(s):  
Epithelial Cells ◽  
Oxidative Damage ◽  
Malignant Transformation ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial

scholarly journals Involvement of p53 Mutation and Mismatch Repair Proteins Dysregulation in NNK-Induced Malignant Transformation of Human Bronchial Epithelial Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ying Shen ◽  
Shuilian Zhang ◽  
Xiaobin Huang ◽  
Kailin Chen ◽  
Jing Shen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Malignant Transformation ◽  
P53 Mutation ◽  
Bronchial Epithelial Cells ◽  
Genome Integrity ◽  
Human Bronchial Epithelial Cells ◽  
Cellular Functions ◽  
Independent Manner ◽  
Bronchial Epithelial ◽  
Cycle Arrest

Genome integrity is essential for normal cellular functions and cell survival. Its instability can cause genetic aberrations and is considered as a hallmark of most cancers. To investigate the carcinogenesis process induced by tobacco-specific carcinogen NNK, we studied the dynamic changes of two important protectors of genome integrity, p53 and MMR system, in malignant transformation of human bronchial epithelial cells after NNK exposure. Our results showed that the expression of MLH1, one of the important MMR proteins, was decreased early and maintained the downregulation during the transformation in a histone modification involved and DNA methylation-independent manner. Another MMR protein PMS2 also displayed a declined expression while being in a later stage of transformation. Moreover, we conducted p53 mutation analysis and revealed a mutation at codon 273 which led to the replacement of arginine by histidine. With the mutation, DNA damage-induced activation of p53 was significantly impaired. We further reintroduced the wild-type p53 into the transformed cells, and the malignant proliferation can be abrogated by inducing cell cycle arrest and apoptosis. These findings indicate that p53 and MMR system play an important role in the initiation and progression of NNK-induced transformation, and p53 could be a potential therapeutic target for tobacco-related cancers.

In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene

2012 ◽  
Vol 26 (2) ◽  
pp. 362-368 ◽  
Author(s):  
Peng Zhao ◽  
Juanling Fu ◽  
Biyun Yao ◽  
Yanchao Song ◽  
Lan Mi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Malignant Transformation ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial

scholarly journals Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

Autophagy ◽  
2016 ◽  
Vol 12 (10) ◽  
pp. 1687-1703 ◽  
Author(s):  
Haishan Huang ◽  
Junlan Zhu ◽  
Yang Li ◽  
Liping Zhang ◽  
Jiayan Gu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Malignant Transformation ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial
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