Postchronic Single-Walled Carbon Nanotube Exposure Causes Irreversible Malignant Transformation of Human Bronchial Epithelial Cells through DNA Methylation Changes

ACS Nano ◽  
2021 ◽  
Vol 15 (4) ◽  
pp. 7094-7104
Author(s):  
Jin Wang ◽  
Xin Tian ◽  
Jie Zhang ◽  
Lirong Tan ◽  
Nan Ouyang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Carbon Nanotube ◽  
Epithelial Cells ◽  
Malignant Transformation ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Single Walled Carbon Nanotube ◽  
Bronchial Epithelial ◽  
Single Walled Carbon

Raw single-walled carbon nanotube-induced cytotoxic effects in human bronchial epithelial cells: comparison to asbestos

2011 ◽  
Vol 93 (5) ◽  
pp. 1045-1072 ◽  
Author(s):  
Maricica Pacurari ◽  
Diane Schwegler-Berry ◽  
Sherri Friend ◽  
Steven S. Leonard ◽  
Robert R. Mercer ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Epithelial Cells ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Cytotoxic Effects ◽  
Single Walled Carbon Nanotube ◽  
Bronchial Epithelial ◽  
Single Walled Carbon

scholarly journals Involvement of p53 Mutation and Mismatch Repair Proteins Dysregulation in NNK-Induced Malignant Transformation of Human Bronchial Epithelial Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Ying Shen ◽  
Shuilian Zhang ◽  
Xiaobin Huang ◽  
Kailin Chen ◽  
Jing Shen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Malignant Transformation ◽  
P53 Mutation ◽  
Bronchial Epithelial Cells ◽  
Genome Integrity ◽  
Human Bronchial Epithelial Cells ◽  
Cellular Functions ◽  
Independent Manner ◽  
Bronchial Epithelial ◽  
Cycle Arrest

Genome integrity is essential for normal cellular functions and cell survival. Its instability can cause genetic aberrations and is considered as a hallmark of most cancers. To investigate the carcinogenesis process induced by tobacco-specific carcinogen NNK, we studied the dynamic changes of two important protectors of genome integrity, p53 and MMR system, in malignant transformation of human bronchial epithelial cells after NNK exposure. Our results showed that the expression of MLH1, one of the important MMR proteins, was decreased early and maintained the downregulation during the transformation in a histone modification involved and DNA methylation-independent manner. Another MMR protein PMS2 also displayed a declined expression while being in a later stage of transformation. Moreover, we conducted p53 mutation analysis and revealed a mutation at codon 273 which led to the replacement of arginine by histidine. With the mutation, DNA damage-induced activation of p53 was significantly impaired. We further reintroduced the wild-type p53 into the transformed cells, and the malignant proliferation can be abrogated by inducing cell cycle arrest and apoptosis. These findings indicate that p53 and MMR system play an important role in the initiation and progression of NNK-induced transformation, and p53 could be a potential therapeutic target for tobacco-related cancers.

Role of PARP-1 on B(a)P induced DNA methylation variation in human bronchial epithelial cells

2010 ◽  
Vol 196 ◽  
pp. S177-S178
Author(s):  
Z.X. Zhuang ◽  
G.H. Tao ◽  
C.M. Gong ◽  
L.Q. Yang ◽  
H.Y. Huang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Epithelial Cells ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial ◽  
Parp 1 ◽  
Methylation Variation

In vitro malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene

2012 ◽  
Vol 26 (2) ◽  
pp. 362-368 ◽  
Author(s):  
Peng Zhao ◽  
Juanling Fu ◽  
Biyun Yao ◽  
Yanchao Song ◽  
Lan Mi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Malignant Transformation ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial

scholarly journals Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

Autophagy ◽  
2016 ◽  
Vol 12 (10) ◽  
pp. 1687-1703 ◽  
Author(s):  
Haishan Huang ◽  
Junlan Zhu ◽  
Yang Li ◽  
Liping Zhang ◽  
Jiayan Gu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Malignant Transformation ◽  
Bronchial Epithelial Cells ◽  
Human Bronchial Epithelial Cells ◽  
Bronchial Epithelial
Sign in / Sign up

Export Citation Format

Share Document