Tacrolimus and Methotrexate for the Prophylaxis of Graft-Versus-Host Disease After Unrelated Donor Cord Blood Transplantation for Adult Patients With Hematologic Malignancies

2007 ◽  
Vol 39 (5) ◽  
pp. 1615-1619 ◽  
Author(s):  
T. Mori ◽  
Y. Aisa ◽  
T. Nakazato ◽  
R. Yamazaki ◽  
T. Shimizu ◽  
...  
Keyword(s):  
Cord Blood ◽  
Graft Versus Host Disease ◽  
Cord Blood Transplantation ◽  
Hematologic Malignancies ◽  
Adult Patients ◽  
Unrelated Donor ◽  
Host Disease ◽  
Graft Versus Host ◽  
Blood Transplantation

Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in Japan

Blood ◽  
2008 ◽  
Vol 112 (6) ◽  
pp. 2579-2582 ◽  
Author(s):  
Hiroto Narimatsu ◽  
Shigesaburo Miyakoshi ◽  
Takuhiro Yamaguchi ◽  
Masahiro Kami ◽  
Tomoko Matsumura ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Cord Blood ◽  
Graft Versus Host Disease ◽  
Cord Blood Transplantation ◽  
Chronic Gvhd ◽  
Japanese Patients ◽  
Hematologic Malignancies ◽  
Host Disease ◽  
Graft Versus Host ◽  
Blood Transplantation

Abstract We have little information on chronic graft-versus-host disease (GVHD) after cord blood transplantation (CBT). We investigated its clinical features in 1072 Japanese patients with hematologic malignancies who received a transplant through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic GVHD. Median age of the patients was 33 years (range, 0-79 years). The cumulative incidence of chronic GVHD 2 years after transplantation was 28%. Chronic GVHD was fatal in 29 patients. Multivariate analysis demonstrated that development of chronic GVHD was favorably associated with both overall survival and event-free survival. Multivariate analysis identified risk factors of chronic GVHD: higher patient body weight, higher number of mismatched antigens for GVHD direction, myeloablative preparative regimen, use of mycophenolate mofetil in GVHD prophylaxis, and development of grades II to IV acute GVHD. Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects.

scholarly journals Tacrolimus for prevention of graft-versus-host disease after mismatched unrelated donor cord blood transplantation

1999 ◽  
Vol 23 (12) ◽  
pp. 1291-1295 ◽  
Author(s):  
D Przepiorka ◽  
D Petropoulos ◽  
CA Mullen ◽  
M Danielson ◽  
V Mattewada ◽  
...  
Keyword(s):  
Cord Blood ◽  
Graft Versus Host Disease ◽  
Cord Blood Transplantation ◽  
Unrelated Donor ◽  
Host Disease ◽  
Graft Versus Host ◽  
Blood Transplantation

scholarly journals Guidelines for the Prevention and Management of Graft-versus-Host Disease after Cord Blood Transplantation

2021 ◽  
Vol 27 (7) ◽  
pp. 540-544
Author(s):  
Doris M. Ponce ◽  
Ioannis Politikos ◽  
Amin Alousi ◽  
Paul A. Carpenter ◽  
Filippo Milano ◽  
...  
Keyword(s):  
Cord Blood ◽  
Graft Versus Host Disease ◽  
Cord Blood Transplantation ◽  
Host Disease ◽  
Graft Versus Host ◽  
Blood Transplantation

Does Cord Blood Transplantation Result in Lower Graft-Versus-Host Disease?

1997 ◽  
Vol 56 (1-2) ◽  
pp. 1-5 ◽  
Author(s):  
J.A Madrigal ◽  
S.B.A Cohen ◽  
E Gluckman ◽  
D.J Charron
Keyword(s):  
Cord Blood ◽  
Graft Versus Host Disease ◽  
Cord Blood Transplantation ◽  
Host Disease ◽  
Graft Versus Host ◽  
Blood Transplantation
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