A Free Radical Scavenger, Edaravone, Prevents Ischemia-Reperfusion Injury in Liver Grafts From Non–Heart-Beating Donors

2008 ◽  
Vol 40 (7) ◽  
pp. 2171-2174 ◽  
Author(s):  
A. Nakamura ◽  
Y. Akamatsu ◽  
S. Miyagi ◽  
T. Fukumori ◽  
S. Sekiguchi ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Heart Beating

MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats

2005 ◽  
Vol 18 (7) ◽  
pp. 844-853 ◽  
Author(s):  
Fumitaka Suzuki ◽  
Yasuhiko Hashikura ◽  
Hirohiko Ise ◽  
Akiko Ishida ◽  
Jun Nakayama ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Free Radical Scavenger ◽  
Warm Ischemia ◽  
Radical Scavenger

Effect of the Free Radical Scavenger MCI-186 on Pulmonary Ischemia–Reperfusion Injury in Dogs

2006 ◽  
Vol 25 (8) ◽  
pp. 965-971 ◽  
Author(s):  
Takahiko Akao ◽  
Izumi Takeyoshi ◽  
Osamu Totsuka ◽  
Kazuhisa Arakawa ◽  
Masato Muraoka ◽  
...  
Keyword(s):  
Free Radical ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Pulmonary Ischemia

Effect of the free radical scavenger edaravone on peripheral nerve ischemia-reperfusion injury

2009 ◽  
Vol 40 (4) ◽  
pp. 582-588 ◽  
Author(s):  
Haruyasu Iida ◽  
Takamura Nagasaka ◽  
Kazumasa Shindo ◽  
Zenji Shiozawa
Keyword(s):  
Free Radical ◽  
Peripheral Nerve ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Free Radical Scavenger ◽  
Radical Scavenger

scholarly journals Potential benefits of melatonin in organ transplantation: a review

2016 ◽  
Vol 229 (3) ◽  
pp. R129-R146 ◽  
Author(s):  
Eduardo Esteban-Zubero ◽  
Francisco Agustín García-Gil ◽  
Laura López-Pingarrón ◽  
Moisés Alejandro Alatorre-Jiménez ◽  
Pablo Iñigo-Gil ◽  
...  
Keyword(s):  
Free Radical ◽  
Organ Transplantation ◽  
Graft Rejection ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Antioxidant Defense System ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Therapeutic Tool ◽  
Term Survival

Organ transplantation is a useful therapeutic tool for patients with end-stage organ failure; however, graft rejection is a major obstacle in terms of a successful treatment. Rejection is usually a consequence of a complex immunological and nonimmunological antigen-independent cascade of events, including free radical-mediated ischemia-reperfusion injury (IRI). To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. Melatonin (N-acetyl-5-methoxytryptamine) is a powerful antioxidant and ant-inflammatory agent synthesized from the essential amino acid l-tryptophan; it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. Melatonin has proven to be a potentially useful therapeutic tool in the reduction of graft rejection. Its benefits are based on its direct actions as a free radical scavenger as well as its indirect antioxidative actions in the stimulation of the cellular antioxidant defense system. Moreover, it has significant anti-inflammatory activity. Melatonin has been found to improve the beneficial effects of preservation fluids when they are enriched with the indoleamine. This article reviews the experimental evidence that melatonin is useful in reducing graft failure, especially in cardiac, bone, otolaryngology, ovarian, testicular, lung, pancreas, kidney, and liver transplantation.

Sign in / Sign up

Export Citation Format

Share Document