A preliminary in vitro assessment of polymer-shelled microbubbles in contrast-enhanced ultrasound imaging

Ultrasonics ◽  
2012 ◽  
Vol 52 (3) ◽  
pp. 456-464 ◽  
Author(s):  
C. Sciallero ◽  
G. Paradossi ◽  
A. Trucco
Keyword(s):  
Ultrasound Imaging ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
In Vitro Assessment

scholarly journals Ultrasound-Based Molecular Imaging of Tumors with PTPmu Biomarker-Targeted Nanobubble Contrast Agents

2021 ◽  
Vol 22 (4) ◽  
pp. 1983
Author(s):  
Mette L. Johansen ◽  
Reshani Perera ◽  
Eric Abenojar ◽  
Xinning Wang ◽  
Jason Vincent ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Imaging Modality ◽  
Tyrosine Phosphatase ◽  
Receptor Protein ◽  
Contrast Enhanced Ultrasound ◽  
Core Lipid ◽  
Contrast Enhanced

Ultrasound imaging is a widely used, readily accessible and safe imaging modality. Molecularly-targeted microbubble- and nanobubble-based contrast agents used in conjunction with ultrasound imaging expand the utility of this modality by specifically targeting and detecting biomarkers associated with different pathologies including cancer. In this study, nanobubbles directed to a cancer biomarker derived from the Receptor Protein Tyrosine Phosphatase mu, PTPmu, were evaluated alongside non-targeted nanobubbles using contrast enhanced ultrasound both in vitro and in vivo in mice. In vitro resonant mass and clinical ultrasound measurements showed gas-core, lipid-shelled nanobubbles conjugated to either a PTPmu-directed peptide or a Scrambled control peptide were equivalent. Mice with heterotopic human tumors expressing the PTPmu-biomarker were injected with PTPmu-targeted or control nanobubbles and dynamic contrast-enhanced ultrasound was performed. Tumor enhancement was more rapid and greater with PTPmu-targeted nanobubbles compared to the non-targeted control nanobubbles. Peak tumor enhancement by the PTPmu-targeted nanobubbles occurred within five minutes of contrast injection and was more than 35% higher than the Scrambled nanobubble signal for the subsequent two minutes. At later time points, the signal in tumors remained higher with PTPmu-targeted nanobubbles demonstrating that PTPmu-targeted nanobubbles recognize tumors using molecular ultrasound imaging and may be useful for diagnostic and therapeutic purposes.

Contrast-Enhanced Ultrasound Imaging for Aortic Stent-Graft Surveillance

2003 ◽  
Vol 10 (2) ◽  
pp. 208-217 ◽  
Author(s):  
Maria Fabrizia Giannoni ◽  
Giovanni Palombo ◽  
Enrico Sbarigia ◽  
Francesco Speziale ◽  
Alvaro Zaccaria ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Stent Graft ◽  
Contrast Enhanced Ultrasound ◽  
Aortic Stent Graft ◽  
Contrast Enhanced

scholarly journals Contrast-Enhanced Ultrasound (CEUS) in Non-Traumatic Abdominal Emergencies

2020 ◽  
Vol 06 (03) ◽  
pp. E76-E86
Author(s):  
Diletta Cozzi ◽  
Simone Agostini ◽  
Elena Bertelli ◽  
Michele Galluzzo ◽  
Emanuela Papa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ultrasound Imaging ◽  
Acute Inflammation ◽  
Emergency Setting ◽  
Contrast Enhanced Ultrasound ◽  
First Line ◽  
Additional Information ◽  
Contrast Enhanced ◽  
Conventional Ultrasound ◽  
Abdominal Emergencies

AbstractConventional ultrasound imaging (US) is the first-line investigation in acute non-traumatic abdominal emergencies, but sometimes it needs further examinations, such as computed tomography (CT), to reach a certain diagnosis. Contrast-enhanced ultrasound (CEUS), through injection of contrast medium, may provide the radiologist with additional information that could not be investigated with baseline US. It could help reach a diagnosis and rapidly determine the proper therapy in an emergency setting. The purpose of this review is to explain and illustrate the various possibilities and limitations of CEUS in acute non-traumatic abdominal diseases, in particular acute inflammation, parenchymal infarcts, and hemorrhages.

scholarly journals The biological response of rodent kidneys to low frequency, full volume diagnostic contrast-enhanced ultrasound imaging: Pilot data

Data in Brief ◽  
2019 ◽  
Vol 25 ◽  
pp. 104170
Author(s):  
A. Gloria Nyankima ◽  
Sandeep Kasoji ◽  
Rachel Cianciolo ◽  
Paul A. Dayton ◽  
Emily H. Chang
Keyword(s):  
Ultrasound Imaging ◽  
Low Frequency ◽  
Biological Response ◽  
Contrast Enhanced Ultrasound ◽  
Pilot Data ◽  
Contrast Enhanced ◽  
Full Volume
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