scholarly journals Influence of Microbubble Size and Pulse Amplitude on Hepatocyte Injury Induced by Contrast-Enhanced Diagnostic Ultrasound

2019 ◽  
Vol 45 (1) ◽  
pp. 170-176 ◽  
Author(s):  
Douglas L. Miller ◽  
Xiaofang Lu ◽  
Mario Fabiilli ◽  
Chunyan Dou
Keyword(s):  
Pulse Amplitude ◽  
Diagnostic Ultrasound ◽  
Hepatocyte Injury ◽  
Contrast Enhanced

scholarly journals Hepatocyte Injury Induced by Contrast‐Enhanced Diagnostic Ultrasound

2018 ◽  
Vol 38 (7) ◽  
pp. 1855-1864 ◽  
Author(s):  
Douglas L. Miller ◽  
Xiaofang Lu ◽  
Mario Fabiilli ◽  
Chunyan Dou
Keyword(s):  
Diagnostic Ultrasound ◽  
Hepatocyte Injury ◽  
Contrast Enhanced

scholarly journals Do Anesthetic Techniques Influence the Threshold for Glomerular Capillary Hemorrhage Induced in Rats by Contrast-Enhanced Diagnostic Ultrasound?

2016 ◽  
Vol 35 (2) ◽  
pp. 373-380 ◽  
Author(s):  
Douglas L. Miller ◽  
Xiaofang Lu ◽  
Mario Fabiilli ◽  
Chunyan Dou
Keyword(s):  
Diagnostic Ultrasound ◽  
Anesthetic Techniques ◽  
Glomerular Capillary ◽  
Contrast Enhanced

scholarly journals Contrast-enhanced Ultrasound Imaging Using Capacitive Micromachined Ultrasonic Transducers

2021 ◽  
Author(s):  
Sigrid Husebø Øygard ◽  
Martin L. Ommen ◽  
Borislav G. Tomov ◽  
Søren E. Diederichsen ◽  
Erik V. Thomsen ◽  
...  
Keyword(s):  
Lead Zirconate Titanate ◽  
Pulse Amplitude ◽  
Lead Zirconate ◽  
Ultrasonic Transducers ◽  
Pulse Amplitude Modulation ◽  
Nonlinear Relationship ◽  
Contrast Enhanced Ultrasound ◽  
Capacitive Micromachined Ultrasonic Transducers ◽  
Contrast Enhanced ◽  
3D Printed

Abstract Capacitive micromachined ultrasonic transducers (CMUTs) have a nonlinear relationship between the applied voltage and the emitted signal, which is detrimental to conventional contrast-enhanced ultrasound (CEUS) techniques. Instead, a three-pulse amplitude modulation (AM) sequence has been proposed, which is not adversely affectedby the emitted harmonics. In this paper, this is shown theoretically, and the performance of the sequence is verified using a 4.8 MHz linear CMUT array, and a comparable lead zirconate titanate (PZT) array, across 6 V to 60 V applied AC voltage. CEUS images of the contrast agent SonoVue flowing through a 3D printed hydrogel phantom showed an average enhancement in contrast-to-tissue ratio (CTR) between B-mode and CEUS images of 49.9 dB and 37.4 dB for the PZT array and CMUT, respectively. Furthermore, hydrophone recordings of the emitted signals showed that the nonlinear emissions from the CMUT did not significantly degrade the cancellation in the compounded AM signal, leaving an average of 2% of the emitted power between 26 V and 60 V AC. Thus, it is demonstrated that CMUTs are capable of CEUS imaging independent of the applied excitation voltage when using a three-pulse AM sequence.

scholarly journals The Dependence of Glomerular Capillary Hemorrhage Induced by Contrast Enhanced Diagnostic Ultrasound on Microbubble Diameter

2018 ◽  
Vol 44 (3) ◽  
pp. 613-621 ◽  
Author(s):  
Douglas L. Miller ◽  
Xiaofang Lu ◽  
Chunyan Dou ◽  
Mario L. Fabiilli ◽  
Charles C. Church
Keyword(s):  
Diagnostic Ultrasound ◽  
Glomerular Capillary ◽  
Contrast Enhanced

scholarly journals Ultrasonic imaging: safety considerations

2011 ◽  
Vol 1 (4) ◽  
pp. 686-697 ◽  
Author(s):  
Gail ter Haar
Keyword(s):  
Ultrasound Imaging ◽  
Heart Function ◽  
Diagnostic Ultrasound ◽  
Response To Treatment ◽  
Epidemiological Evidence ◽  
Routine Investigation ◽  
Contrast Enhanced ◽  
Wide Range ◽  
High Street ◽  
Safety Considerations

Modern ultrasound imaging for diagnostic purposes has a wide range of applications. It is used in obstetrics to monitor the progress of pregnancy, in oncology to visualize tumours and their response to treatment, and, in cardiology, contrast-enhanced studies are used to investigate heart function and physiology. An increasing use of diagnostic ultrasound is to provide the first photograph for baby's album—in the form of a souvenir or keepsake scan that might be taken as part of a routine investigation, or during a visit to an independent high-street ‘boutique’. It is therefore important to ensure that any benefit accrued from these applications outweighs any accompanying risk, and to evaluate the existing ultrasound bio-effect and epidemiology literature with this in mind. This review considers the existing laboratory and epidemiological evidence about the safety of diagnostic ultrasound and puts it in the context of current clinical usage.

scholarly journals Contrast-Enhanced Diagnostic Ultrasound Causes Renal Tissue Damage in a Porcine Model

2010 ◽  
Vol 29 (10) ◽  
pp. 1391-1401 ◽  
Author(s):  
Douglas L. Miller ◽  
Chunyan Dou ◽  
Roger C. Wiggins
Keyword(s):  
Tissue Damage ◽  
Porcine Model ◽  
Diagnostic Ultrasound ◽  
Renal Tissue ◽  
Contrast Enhanced

scholarly journals Capillary Hemorrhage Induced by Contrast-Enhanced Diagnostic Ultrasound in Rat Intestine

2019 ◽  
Vol 45 (8) ◽  
pp. 2133-2139 ◽  
Author(s):  
Xiaofang Lu ◽  
Chunyan Dou ◽  
Mario L. Fabiilli ◽  
Douglas L. Miller
Keyword(s):  
Diagnostic Ultrasound ◽  
Rat Intestine ◽  
Contrast Enhanced

Contrast enhanced diagnostic ultrasound induces capillary injury in rat intestine

2019 ◽  
Vol 146 (4) ◽  
pp. 2989-2989
Author(s):  
Douglas Miller ◽  
Xiaofang Lu ◽  
Mario L. Fabiilli ◽  
Chunyan Dou
Keyword(s):  
Diagnostic Ultrasound ◽  
Rat Intestine ◽  
Contrast Enhanced
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