The role of neoadjuvant chemotherapy, lymph node dissection, and treatment delay in patients with muscle-invasive bladder cancer undergoing partial cystectomy

2021 ◽  
Author(s):  
Andrew T. Lenis ◽  
Katherine E. Fero ◽  
Leslie Ojeaburu ◽  
Patrick M. Lec ◽  
Vishnukamal Golla ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Node Dissection ◽  
Treatment Delay ◽  
Invasive Bladder Cancer ◽  
Node Dissection ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

Importance of Node Dissection in Relation to Neoadjuvant and Adjuvant Therapy

2006 ◽  
Vol 4 (10) ◽  
pp. 1019-1026 ◽  
Author(s):  
William C. Huang ◽  
Bernard H. Bochner
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Pelvic Lymph Node Dissection ◽  
Pelvic Lymph Node ◽  
Invasive Bladder Cancer ◽  
Node Dissection ◽  
Muscle Invasive Bladder Cancer ◽  
Quality Of Surgery ◽  
Muscle Invasive

Since the advent of effective chemotherapeutic regimens for treating transitional cell carcinoma, multimodal therapy has become part of the contemporary management of patients with muscle-invasive bladder cancer. However, radical cystectomy with pelvic lymphadenectomy remains the cornerstone of treatment for patients with localized and regionally advanced muscle-invasive disease. The effectiveness of chemotherapy models in bladder cancer can depend greatly on the quality of surgery. Unfortunately, without sufficient level I data, the boundaries of lymphadenectomy and the diagnostic and therapeutic ramifications of variations in the pelvic lymph node dissection remain undetermined. This article examines the role of pelvic lymph node dissection during perioperative chemotherapy and discusses the current challenges in establishing standards for lymphadenectomy in patients undergoing treatment for muscle-invasive bladder cancer.

Pelvic lymph node dissection during radical cystectomy for muscle-invasive bladder cancer

2018 ◽  
Vol 15 (11) ◽  
pp. 686-692 ◽  
Author(s):  
Marlon Perera ◽  
Shannon McGrath ◽  
Shomik Sengupta ◽  
Jack Crozier ◽  
Damien Bolton ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Radical Cystectomy ◽  
Lymph Node Dissection ◽  
Pelvic Lymph Node Dissection ◽  
Pelvic Lymph Node ◽  
Invasive Bladder Cancer ◽  
Node Dissection ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

scholarly journals Lymphadenectomy in Management of Invasive Bladder Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Ramy F. Youssef ◽  
Ganesh V. Raj
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Radical Cystectomy ◽  
Lymph Node Dissection ◽  
Pelvic Lymphadenectomy ◽  
Invasive Bladder Cancer ◽  
Node Dissection ◽  
Surgical Morbidity ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

Radical cystectomy with pelvic lymphadenectomy represents the gold standard for treatment of muscle-invasive bladder cancer. Extent of the lymph node dissection and lymph node involvement during radical cystectomy are the most powerful prognostic factors associated with poor oncological outcome. However, the optimal boundaries of the lymph node dissection during a radical cystectomy are controversial. The published literature based mostly on retrospective studies suggests that increasing the number of nodes excised may have therapeutic and diagnostic benefits without significantly increasing the surgical morbidity. These conclusions are, however, influenced by selection and surgeon biases, inconsistencies in the quality of the surgery, and node count variability. In this paper, we establish the current understanding about the utility of lymphadenectomy during a radical cystectomy for muscle-invasive bladder cancer.

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