Enhanced humoral and mucosal immune responses after intranasal immunization with chimeric multiple antigen peptide of LcrV antigen epitopes of Yersinia pestis coupled to palmitate in mice

Vaccine ◽  
2011 ◽  
Vol 29 (50) ◽  
pp. 9352-9360 ◽  
Author(s):  
SriJayaprakash Babu Uppada ◽  
Ajaz Ahmed Bhat ◽  
Anil Sah ◽  
Rao Nageswara Donthamshetty
Keyword(s):  
Immune Responses ◽  
Yersinia Pestis ◽  
Intranasal Immunization ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide ◽  
Mucosal Immune Responses

scholarly journals Diepitope multiple antigen peptide of hTERT trigger stronger anti-tumor immune responses in vitro

2013 ◽  
Vol 16 (4) ◽  
pp. 444-450 ◽  
Author(s):  
Zhong-Li Liao ◽  
Gang Luo ◽  
Xia Xie ◽  
Xu-Dong Tang ◽  
Jian Ying Bai ◽  
...  
Keyword(s):  
Immune Responses ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide

scholarly journals A membrane penetrating multiple antigen peptide (MAP) incorporating ovalbumin CD8 epitope induces potent immune responses in mice

2010 ◽  
Vol 1798 (12) ◽  
pp. 2286-2295 ◽  
Author(s):  
Nicole A. Brooks ◽  
Dodie S. Pouniotis ◽  
Kuo-Ching Sheng ◽  
Vasso Apostolopoulos ◽  
Geoffrey A. Pietersz
Keyword(s):  
Immune Responses ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide ◽  
Peptide Map

Intranasal immunization with liposome-formulated Yersinia pestis vaccine enhances mucosal immune responses

Vaccine ◽  
2000 ◽  
Vol 18 (21) ◽  
pp. 2203-2211 ◽  
Author(s):  
Maria E. Baca-Estrada ◽  
Marianna Foldvari ◽  
Marlene Snider ◽  
Kent Harding ◽  
Bill Kournikakis ◽  
...  
Keyword(s):  
Immune Responses ◽  
Yersinia Pestis ◽  
Intranasal Immunization ◽  
Mucosal Immune Responses

scholarly journals Immunogenicity of NS4b Dengue 3 Virus Mimotope Presented to the Immune System as Multiple Antigen Peptide System

ISRN Virology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Nevis Amin ◽  
Maritza Pupo ◽  
Alicia Aguilar ◽  
Frank Camacho ◽  
Mayling Alvarez ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Vaccine Design ◽  
Amino Acid Sequences ◽  
Diagnostic Assays ◽  
Random Peptide ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide ◽  
Human Sera ◽  
Phage Displayed Peptide Library

The availability of random peptide libraries displayed on bacteriophage (RPL) has provided a powerful tool for selecting sequences that mimic binding properties of natural antigen epitopes (mimotopes). These mimotopes can be used for vaccine design, drug development, and diagnostic assays. Several mimotopes have been shown to induce production of antibodies against the natural antigen. We have previously identified four dengue virus mimotopes from a phage-displayed peptide library using antidengue 3 human sera. Three of them showed similarity in their amino acid sequences with the NS4b proteins of dengue. Few studies have examined the role of NS4b proteins in the antibody response to dengue virus infection. A multiple antigen peptide (MAP) system was chemically synthesized containing this mimotope (NS4b MAP), and BALB/c mice were immunized to evaluate its immunogenicity. Antipeptide responses were induced and recognised DENV-3 infected cells as determined by immunofluorescence. The high levels of the IgG2a subtype against NS4bMAP suggest the induction of a Th1-like response. Our findings suggest that the NS4b mimotope might be a useful tool for the development of multiepitope diagnostic assays, dengue virus vaccine design, and pathogenesis studies.

Structural probing of human lutropin using antibodies raised against synthetic peptides constructed by classical and multiple antigen peptide system approaches

1990 ◽  
Vol 27 (4) ◽  
pp. 363-368 ◽  
Author(s):  
Frédéric Troalen ◽  
Alain Razafindratsita ◽  
Alain Puisieux ◽  
Thibault Voeltzel ◽  
Claude Bohuon ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide ◽  
Peptide System ◽  
System Approaches

Antibodies for Growth Hormone and Prolactin Using Multiple Antigen Peptide Immunogens

1999 ◽  
Vol 1 (3) ◽  
pp. 211-220 ◽  
Author(s):  
Lucía Irene González-Villaseñor ◽  
Thomas T. Chen
Keyword(s):  
Growth Hormone ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide

Autoantibodies directed against ribosomal P proteins: use of a multiple antigen peptide as the coating agent in ELISA

1995 ◽  
Vol 179 (2) ◽  
pp. 193-202 ◽  
Author(s):  
L. Caponi ◽  
S. Pegoraro ◽  
V. Di Bartolo ◽  
P. Rovero ◽  
R. Revoltella ◽  
...  
Keyword(s):  
Coating Agent ◽  
Multiple Antigen ◽  
Antigen Peptide ◽  
Multiple Antigen Peptide ◽  
P Proteins ◽  
Ribosomal P
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