Dengue virus envelope protein domain III-elicited antibodies mediate cross-protection against Zika virus in a mouse model

2020 ◽  
Vol 278 ◽  
pp. 197882
Author(s):  
Yongchao Zhou ◽  
Dong Chen ◽  
Lan Yang ◽  
Weiwei Zou ◽  
Zhiliang Duan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Dengue Virus ◽  
Zika Virus ◽  
Envelope Protein ◽  
Cross Protection ◽  
Protein Domain ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

scholarly journals Suppressive effect of dengue virus envelope protein domain III on megakaryopoiesis

Virulence ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1719-1731 ◽  
Author(s):  
Guan-Ling Lin ◽  
Hsin-Hou Chang ◽  
Te-Sheng Lien ◽  
Po-Kong Chen ◽  
Hao Chan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Suppressive Effect ◽  
Protein Domain ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

scholarly journals Anti-dengue virus envelope protein domain III IgG ELISA among infants with primary dengue virus infections

Acta Tropica ◽  
2015 ◽  
Vol 142 ◽  
pp. 103-107 ◽  
Author(s):  
Daniel H. Libraty ◽  
Lei Zhang ◽  
AnaMae Obcena ◽  
Job D. Brion ◽  
Rosario Z. Capeding
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Protein Domain ◽  
Virus Infections ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

Paradoxical Role of Dengue Virus Envelope Protein Domain III Antibodies in Dengue Virus Infection

2020 ◽  
Vol 30 (3) ◽  
pp. 199-206
Author(s):  
Sheeza Ali ◽  
Samia Afzal ◽  
Muhammad Zubair Yousaf ◽  
Muhammad Shahid ◽  
Iram Amin ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Envelope Protein ◽  
Protein Domain ◽  
Virus Envelope ◽  
Dengue Virus Infection ◽  
Virus Envelope Protein ◽  
Domain Iii

scholarly journals Production of dengue virus envelope protein domain III-based antigens in tobacco chloroplasts using inducible and constitutive expression systems

2016 ◽  
Vol 91 (4-5) ◽  
pp. 497-512 ◽  
Author(s):  
Johanna Gottschamel ◽  
Andreas Lössl ◽  
Stephanie Ruf ◽  
Yanliang Wang ◽  
Morten Skaugen ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Envelope Protein ◽  
Constitutive Expression ◽  
Protein Domain ◽  
Expression Systems ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

scholarly journals Dengue Virus Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent NETosis-Mediated Inflammation in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Te-Sheng Lien ◽  
Der-Shan Sun ◽  
Shih-Che Hung ◽  
Wen-Sheng Wu ◽  
Hsin-Hou Chang
Keyword(s):  
Dengue Virus ◽  
Nlrp3 Inflammasome ◽  
Envelope Protein ◽  
Protein Domain ◽  
Severe Dengue ◽  
Cytokine Storm ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii

Abnormal immune responses and cytokine storm are involved in the development of severe dengue, a life-threatening disease with high mortality. Dengue virus-induced neutrophil NETosis response is associated with cytokine storm; while the role of viral factors on the elicitation of excessive inflammation mains unclear. Here we found that treatments of dengue virus envelope protein domain III (EIII), cellular binding moiety of virion, is sufficient to induce neutrophil NETosis processes in vitro and in vivo. Challenges of EIII in inflammasome Nlrp3−/− and Casp1−/− mutant mice resulted in less inflammation and NETosis responses, as compared to the wild type controls. Blockages of EIII-neutrophil interaction using cell-binding competitive inhibitor or selective Nlrp3 inflammasome inhibitors OLT1177 and Z-WHED-FMK can suppress EIII-induced NETosis response. These results collectively suggest that Nlrp3 inflammsome is a molecular target for treating dengue-elicited inflammatory pathogenesis.

scholarly journals Immunization of Zika virus envelope protein domain III induces specific and neutralizing immune responses against Zika virus

Vaccine ◽  
2017 ◽  
Vol 35 (33) ◽  
pp. 4287-4294 ◽  
Author(s):  
Ming Yang ◽  
Matthew Dent ◽  
Huafang Lai ◽  
Haiyan Sun ◽  
Qiang Chen
Keyword(s):  
Immune Responses ◽  
Zika Virus ◽  
Envelope Protein ◽  
Protein Domain ◽  
Virus Envelope ◽  
Virus Envelope Protein ◽  
Domain Iii
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