Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping

2019 ◽  
Vol 108 (4) ◽  
pp. 1627-1630 ◽  
Author(s):  
Xin Yang ◽  
Nathaniel Johnson ◽  
Li Di
Keyword(s):  
Cytochrome P450 ◽  
Aldehyde Oxidase ◽  
Oxidase Inhibitor ◽  
Reaction Phenotyping

Strain Difference of Oxidative Metabolism of the Sedative-hypnotic Zaleplon by Aldehyde Oxidase and Cytochrome P450 In Vivo and In Vitro in Rats

2013 ◽  
Vol 28 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Chiaki Tanoue ◽  
Kazumi Sugihara ◽  
Naoto Uramaru ◽  
Yoko Watanabe ◽  
Yoshitaka Tayama ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Oxidative Metabolism ◽  
Strain Difference ◽  
Aldehyde Oxidase

Cytochrome P450 reaction phenotyping and inhibition and induction studies of pinostrobin in human liver microsomes and hepatocytes

2017 ◽  
Vol 31 (6) ◽  
pp. e3888 ◽  
Author(s):  
Shengnan Tan ◽  
Zhimin Dong ◽  
Jiashuo Zhang ◽  
Thomas Efferth ◽  
Yujie Fu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Reaction Phenotyping

Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery

2015 ◽  
Vol 30 (2) ◽  
pp. 301-310 ◽  
Author(s):  
Esra Nurten Cece-Esencan ◽  
Fabien Fontaine ◽  
Guillem Plasencia ◽  
Marieke Teppner ◽  
Andreas Brink ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Discovery ◽  
Kinetic Analysis ◽  
Reaction Phenotyping ◽  
Early Drug

CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate

2021 ◽  
pp. DMD-AR-2021-000665
Author(s):  
Daigo Asano ◽  
Syoya Hamaue ◽  
Hamim Zahir ◽  
Hideyuki Shiozawa ◽  
Yumi Nishiya ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Aldehyde Oxidase

Cytochrome P450 Reaction Phenotyping

2003 ◽  
pp. 255-310 ◽  
Author(s):  
Jeffrey Stevens ◽  
Larry Wienkers
Keyword(s):  
Cytochrome P450 ◽  
Reaction Phenotyping

Cytochrome P450 reaction-phenotyping: an industrial perspective

2007 ◽  
Vol 3 (5) ◽  
pp. 667-687 ◽  
Author(s):  
Hongjian Zhang ◽  
Carl D Davis ◽  
Michael W Sinz ◽  
A David Rodrigues
Keyword(s):  
Cytochrome P450 ◽  
Reaction Phenotyping
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