scholarly journals Sox3 expression is maintained by FGF signaling and restricted to the neural plate by Vent proteins in the Xenopus embryo

2008 ◽  
Vol 313 (1) ◽  
pp. 307-319 ◽  
Author(s):  
Crystal D. Rogers ◽  
Tenley C. Archer ◽  
Doreen D. Cunningham ◽  
Timothy C. Grammer ◽  
Elena M. Silva Casey
Keyword(s):  
Neural Plate ◽  
Xenopus Embryo ◽  
Fgf Signaling

FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain

Development ◽  
2002 ◽  
Vol 129 (16) ◽  
pp. 3825-3837 ◽  
Author(s):  
Lisa Maves ◽  
William Jackman ◽  
Charles B. Kimmel
Keyword(s):  
Neuronal Differentiation ◽  
Crucial Role ◽  
Time Lapse ◽  
Signaling Molecules ◽  
Neural Plate ◽  
Fgf Signaling ◽  
Genetic Mosaic ◽  
Signaling Center ◽  
Signaling Activity ◽  
Rhombomere 4

The segmentation of the vertebrate hindbrain into rhombomeres is highly conserved, but how early hindbrain patterning is established is not well understood. We show that rhombomere 4 (r4) functions as an early-differentiating signaling center in the zebrafish hindbrain. Time-lapse analyses of zebrafish hindbrain development show that r4 forms first and hindbrain neuronal differentiation occurs first in r4. Two signaling molecules, FGF3 and FGF8, which are both expressed early in r4, are together required for the development of rhombomeres adjacent to r4, particularly r5 and r6. Transplantation of r4 cells can induce expression of r5/r6 markers, as can misexpression of either FGF3 or FGF8. Genetic mosaic analyses also support a role for FGF signaling acting from r4. Taken together, our findings demonstrate a crucial role for FGF-mediated inter-rhombomere signaling in promoting early hindbrain patterning and underscore the significance of organizing centers in patterning the vertebrate neural plate.

Expression zones of three novel genes abut the developing anterior neural plate of Xenopus embryo

2003 ◽  
Vol 3 (2) ◽  
pp. 225-230 ◽  
Author(s):  
V.V Novoselov ◽  
E.M Alexandrova ◽  
G.V Ermakova ◽  
A.G Zaraisky
Keyword(s):  
Neural Plate ◽  
Xenopus Embryo ◽  
Novel Genes ◽  
Anterior Neural Plate

scholarly journals 21-P034 Extracellular regulation of FGF signaling in the early Xenopus embryo

2009 ◽  
Vol 126 ◽  
pp. S323
Author(s):  
Tan Hooi Min ◽  
Dobromir Iliev ◽  
Edgar M. Pera
Keyword(s):  
Xenopus Embryo ◽  
Fgf Signaling

scholarly journals The Secreted Serine Protease xHtrA1 Stimulates Long-Range FGF Signaling in the Early Xenopus Embryo

2007 ◽  
Vol 13 (2) ◽  
pp. 226-241 ◽  
Author(s):  
Shirui Hou ◽  
Marco Maccarana ◽  
Tan H. Min ◽  
Ina Strate ◽  
Edgar M. Pera
Keyword(s):  
Serine Protease ◽  
Long Range ◽  
Xenopus Embryo ◽  
Fgf Signaling

scholarly journals BMP antagonists and FGF signaling contribute to different domains of the neural plate in Xenopus

2010 ◽  
Vol 337 (2) ◽  
pp. 335-350 ◽  
Author(s):  
Andrea E. Wills ◽  
Vivian M. Choi ◽  
Margaux J. Bennett ◽  
Mustafa K. Khokha ◽  
Richard M. Harland
Keyword(s):  
Neural Plate ◽  
Fgf Signaling ◽  
Bmp Antagonists

The Wnt-activated Xiro1 gene encodes a repressor that is essential for neural development and downregulates Bmp4

Development ◽  
2001 ◽  
Vol 128 (4) ◽  
pp. 551-560 ◽  
Author(s):  
J. Gomez-Skarmeta ◽  
E. de La Calle-Mustienes ◽  
J. Modolell
Keyword(s):  
Wnt Signaling ◽  
Neural Development ◽  
Neural Differentiation ◽  
Neural Plate ◽  
Xenopus Embryo ◽  
Homeodomain Proteins ◽  
Proneural Genes ◽  
Family Control

In the early Xenopus embryo, the Xiro homeodomain proteins of the Iroquois (Iro) family control the expression of proneural genes and the size of the neural plate. We report that Xiro1 functions as a repressor that is strictly required for neural differentiation, even when the BMP4 pathway is impaired. We also show that Xiro1 and Bmp4 repress each other. Consistently, Xiro1 and Bmp4 have complementary patterns of expression during gastrulation. The expression of Xiro1 requires Wnt signaling. Thus, Xiro1 is probably a mediator of the known downregulation of Bmp4 by Wnt signaling.

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