scholarly journals TGF-β mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue–tissue interactions during tongue morphogenesis

2010 ◽  
Vol 341 (1) ◽  
pp. 186-195 ◽  
Author(s):  
Ryoichi Hosokawa ◽  
Kyoko Oka ◽  
Takayoshi Yamaza ◽  
Junichi Iwata ◽  
Mark Urata ◽  
...  
Keyword(s):  
Neural Crest ◽  
Progenitor Cells ◽  
Neural Crest Cells ◽  
Cranial Neural Crest ◽  
Tissue Interactions ◽  
Cranial Neural Crest Cells ◽  
Myogenic Progenitor Cells ◽  
Myogenic Progenitor

scholarly journals FGF2 promotes skeletogenic differentiation of cranial neural crest cells

Development ◽  
2001 ◽  
Vol 128 (11) ◽  
pp. 2143-2152 ◽  
Author(s):  
Sanjukta Sarkar ◽  
Anita Petiot ◽  
Andrew Copp ◽  
Patrizia Ferretti ◽  
Peter Thorogood
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Dependent Manner ◽  
Cranial Neural Crest ◽  
Fibroblast Growth Factor Receptors ◽  
Tissue Interactions ◽  
Membrane Bone ◽  
Cartilage Differentiation ◽  
Cranial Neural Crest Cells

The cranial neural crest gives rise to most of the skeletal tissues of the skull. Matrix-mediated tissue interactions have been implicated in the skeletogenic differentiation of crest cells, but little is known of the role that growth factors might play in this process. The discovery that mutations in fibroblast growth factor receptors (FGFRs) cause the major craniosynostosis syndromes implicates FGF-mediated signalling in the skeletogenic differentiation of the cranial neural crest. We now show that, in vitro, mesencephalic neural crest cells respond to exogenous FGF2 in a dose-dependent manner, with 0.1 and 1 ng/ml causing enhanced proliferation, and 10 ng/ml inducing cartilage differentiation. In longer-term cultures, both endochondral and membrane bone are formed. FGFR1, FGFR2 and FGFR3 are all detectable by immunohistochemistry in the mesencephalic region, with particularly intense expression at the apices of the neural folds from which the neural crest arises. FGFRs are also expressed by subpopulations of neural crest cells in culture. Collectively, these findings suggest that FGFs are involved in the skeletogenic differentiation of the cranial neural crest.

Laser capture microdissection of fluorescently labeled embryonic cranial neural crest cells

genesis ◽  
2004 ◽  
Vol 39 (1) ◽  
pp. 58-64 ◽  
Author(s):  
Vasker Bhattacherjee ◽  
Partha Mukhopadhyay ◽  
Saurabh Singh ◽  
Emily A. Roberts ◽  
Rita C. Hackmiller ◽  
...  
Keyword(s):  
Neural Crest ◽  
Laser Capture Microdissection ◽  
Neural Crest Cells ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cells ◽  
Laser Capture

scholarly journals Cranial neural crest cells on the move: Their roles in craniofacial development

2010 ◽  
Vol 155 (2) ◽  
pp. 270-279 ◽  
Author(s):  
Dwight R. Cordero ◽  
Samantha Brugmann ◽  
Yvonne Chu ◽  
Ruchi Bajpai ◽  
Maryam Jame ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Craniofacial Development ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cells
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