Natural history of persistent high-risk human papillomavirus infections in Korean women

2009 ◽  
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pp. 75-80 ◽  
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Jaeman Bae ◽  
Sang-Soo Seo ◽  
Young-Soo Park ◽  
Seung-Myung Dong ◽  
Sokbom Kang ◽  
...  
2013 ◽  
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Joshua E. Stern ◽  
Laura Newman ◽  
...  

2015 ◽  
Vol 137 (10) ◽  
pp. 2432-2442 ◽  
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Tsung-chieh Jane Fu ◽  
Long Fu Xi ◽  
Ayaka Hulbert ◽  
James P. Hughes ◽  
Qinghua Feng ◽  
...  

2010 ◽  
Vol 20 (4) ◽  
pp. 699-707 ◽  
Author(s):  
Rachel L. Winer ◽  
James P. Hughes ◽  
Qinghua Feng ◽  
Long Fu Xi ◽  
Stephen Cherne ◽  
...  

2011 ◽  
Vol 48 (5) ◽  
pp. 473-480 ◽  
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Bree Weaver ◽  
Marcia Shew ◽  
Brahim Qadadri ◽  
Wanzhu Tu ◽  
Yan Tong ◽  
...  

Author(s):  
I Mary Poynten ◽  
Fengyi Jin ◽  
Suzanne M Garland ◽  
Richard J Hillman ◽  
Monica Molano ◽  
...  

Abstract Objectives Incidence of anal cancer is highest in gay and bisexual men (GBM). A better understanding of the natural history of anal high-risk human papillomavirus (HRHPV) infection is needed for anal cancer prevention. Methods The Study of the Prevention of Anal Cancer was a 3-year study of Australian GBM, aged 35 years or older. We examined incidence, clearance and risk factors for 13 HRHPV types tested for at baseline and 3 annual visits. Results In 525 men with ≥ 2 visits, 348 (66.3%) acquired ≥ 1 incident HRHPV infection. HPV16 incidence rates were similar, but non-16 HRHPV incidence was higher in HIV-positive (51.8/100 person years, PY) than HIV-negative men (36.5/100 PY, p < 0.001). Annual clearance rates of HPV16 (13.21/100 PY, 95% CI 10.53-16.56) were lower than for other HRHPV types. HRHPV clearance rates were not associated with HIV overall but were significantly lower in those with a lower nadir CD4 (<200 cells/µl) for HPV16 (p=0.015) and other HRHPV types (p=0.007). Conclusion The higher incidence of non-16 HRHPV types, coupled with the lower clearance of non-16 HRHPV types in those with past impaired immune function, is consistent with the greater role of non-16 HRHPV in anal cancer in HIV-positive people.


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